{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:15:34Z","timestamp":1789661734891,"version":"4.0.1"},"reference-count":27,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The origin of novelty is one of the least understood evolutionary phenomena. One approach to study evolutionary novelty comes from developmental biology. During developmental cell fate specification of the nematode Pristionchus pacificus (Diplogastridae), five cell fates can be distinguished within a group of twelve ventral epidermal cells. The differentiation pattern of individual cells includes programmed cell death, cell fusion and vulval differentiation after induction by the gonad. A cell lineage comparison among species of seven different genera of the Diplogastridae indicates that the differentiation pattern of ventral epidermal cells is highly conserved. Despite this morpho-logical conservation, cell ablation experiments indicate many independent alterations of underlying mechanisms of cell fate specification. Cell fusion and individual cell competence change during evolution as well as the differentiation property in response to inductive signaling. These results suggest that developmental mechanisms, some of which are redundantly involved in vulval fate specification of the genetic model organism Caenorhabditis elegans, can evolve without concomitant morphological change.<\/jats:p>","DOI":"10.1242\/dev.124.1.243","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T22:44:01Z","timestamp":1619390641000},"page":"243-251","source":"Crossref","is-referenced-by-count":39,"title":["Evolutionary changes of developmental mechanisms in the absence of cell lineage alterations during vulva formation in the Diplogastridae (Nematoda)"],"prefix":"10.1242","volume":"124","author":[{"given":"Ralf J.","family":"Sommer","sequence":"first","affiliation":[{"name":"Max-Planck Institut f\u00fcr Entwicklungsbiologie , Abteilung Zellbiologie, Spemannstrasse 35, 72076 T\u00fcbingen, Germany (e-mail: sora@fserv1.mpib-tuebingen.mpg.de )"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,1,1]]},"reference":[{"key":"2025021400104791300_DEVELOP_124_1_243C1","doi-asserted-by":"crossref","DOI":"10.1515\/9783112484586","volume-title":"Klasse Nematoda","author":"Andrassy","year":"1984"},{"key":"2025021400104791300_DEVELOP_124_1_243C2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0092-8674(87)90593-9","article-title":"A cell that dies during wild-type C.elegans development can function as a neuron in a ced-3 mutant","volume":"51","author":"Avery","year":"1987","journal-title":"Cell"},{"key":"2025021400104791300_DEVELOP_124_1_243C3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2025021400104791300_DEVELOP_124_1_243C4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0168-9525(86)90211-8","article-title":"Molecular drive in multigene families: how biological novelties arise, spread and are assimilated","volume":"2","author":"Dover","year":"1986","journal-title":"Trends in Genetics"},{"key":"2025021400104791300_DEVELOP_124_1_243C5","first-page":"82","article-title":"Punctuated equilibria: an alternative to phyletic gradualism","volume-title":"In Models in Palaeobiology","author":"Eldredge","year":"1972"},{"key":"2025021400104791300_DEVELOP_124_1_243C6","volume-title":"Soil and freshwater nematodes","author":"Goodey","year":"1963"},{"key":"2025021400104791300_DEVELOP_124_1_243C7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/scdb.1996.0024","article-title":"Intercellular signalling in Caenorhabditis elegans vulval pattern formation","volume":"7","author":"Katz","year":"1996","journal-title":"Sem. Cell Dev. Biol"},{"key":"2025021400104791300_DEVELOP_124_1_243C8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0012-1606(81)90152-4","article-title":"Lineage alterations after ablation of cells in the somatic gonad of C. elegans","volume":"87","author":"Kimble","year":"1981","journal-title":"Dev. Biol"},{"key":"2025021400104791300_DEVELOP_124_1_243C9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0012-1606(79)90035-6","article-title":"Post-embryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans","volume":"70","author":"Kimble","year":"1979","journal-title":"Dev. Biol"},{"key":"2025021400104791300_DEVELOP_124_1_243C10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/scientificamerican1179-98","article-title":"The neutral theorey of molecular evolution","volume":"241","author":"Kimura","year":"1979","journal-title":"Scient. Amer"},{"key":"2025021400104791300_DEVELOP_124_1_243C11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.1090005","article-title":"Evolution at two levels in humans and chimpanzees","volume":"188","author":"King","year":"1975","journal-title":"Science"},{"key":"2025021400104791300_DEVELOP_124_1_243C12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1163\/004325996X00039","article-title":"Diplogaster (Diplogastrellus) cerea sp. n. from saguaro cactus rot and a revision of the subgenus Diplogastrellus(Nematoda: Diplogastridae)","volume":"42","author":"Kiontke","year":"1996","journal-title":"Nematologica"},{"key":"2025021400104791300_DEVELOP_124_1_243C13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1126\/science.8016644","article-title":"Changes of induction and competence during the evolution of vulva development in nematodes","volume":"265","author":"Sommer","year":"1994","journal-title":"Science"},{"key":"2025021400104791300_DEVELOP_124_1_243C14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/dbio.1995.1007","article-title":"Evolution of cell lineage and pattern formation in the vulva equivalence group of rhabditid nematodes","volume":"167","author":"Sommer","year":"1995","journal-title":"Dev. Biol"},{"key":"2025021400104791300_DEVELOP_124_1_243C15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0960-9822(02)00421-9","article-title":"Apoptosis limits the size of the vulval equivalence group in Pristionchus pacificus: a genetic analysis","volume":"6","author":"Sommer","year":"1996","journal-title":"Current Biology"},{"key":"2025021400104791300_DEVELOP_124_1_243C16","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1006\/dbio.1996.0035","article-title":"Evolution of nematode vulval fate patterning","volume":"173","author":"Sommer","year":"1996","journal-title":"Dev. Biol"},{"issue":"Supplement","key":"2025021400104791300_DEVELOP_124_1_243C17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1242\/dev.1994.Supplement.85","article-title":"The evolution of cell lineage in nematodes","volume":"1994","author":"Sommer","year":"1994","journal-title":"Development"},{"key":"2025021400104791300_DEVELOP_124_1_243C18","first-page":"511","article-title":"Morphological, genetic and molecular description of Pristionchus pacificus sp.n. (Nematoda: Neodiplogastridae)","volume":"19","author":"Sommer","year":"1996","journal-title":"Fund. Appl. Nemat"},{"key":"2025021400104791300_DEVELOP_124_1_243C19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0012-1606(81)90226-8","article-title":"Gonadal cell lineages of the nematode Panagrellus redivivus and implications for evolution by modification of cell lineage","volume":"88","author":"Sternberg","year":"1981","journal-title":"Dev. Biol"},{"key":"2025021400104791300_DEVELOP_124_1_243C20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(86)90842-1","article-title":"Pattern formation during vulval development in C. elegans","volume":"44","author":"Sternberg","year":"1986","journal-title":"Cell"},{"key":"2025021400104791300_DEVELOP_124_1_243C21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(89)90103-7","article-title":"The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans","volume":"58","author":"Sternberg","year":"1989","journal-title":"Cell"},{"key":"2025021400104791300_DEVELOP_124_1_243C22","article-title":"Vergleichende Untersuchungen zur Phylogenetik, Systematik, \u00d6kologie, Biologie und Ethologie der Rhabditidae (Nematoda)","volume":"43","author":"Sudhaus","year":"1976","journal-title":"Zoologica, Schweizerbart\u2035sche Verlagsbuchhandlung Stuttgart"},{"key":"2025021400104791300_DEVELOP_124_1_243C23","first-page":"51","article-title":"Diplogaster coprophilus n. sp. and D. affinis n. sp. (Nematoda, Rhabditida) from cow pats and related species, with notes on distribution, ecology and phylogeny","volume":"13","author":"Sudhaus","year":"1990","journal-title":"Rev. Nemat"},{"key":"2025021400104791300_DEVELOP_124_1_243C24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Postembryonic cell lineage of the nematode C. elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol"},{"key":"2025021400104791300_DEVELOP_124_1_243C25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0012-1606(80)90353-X","article-title":"Regulation and cell autonomy during postembryonic development in Caenorhabditis elegans","volume":"78","author":"Sulston","year":"1980","journal-title":"Dev. Biol"},{"key":"2025021400104791300_DEVELOP_124_1_243C26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/bies.950180609","article-title":"Control and integration of cell signaling pathways during C. elegans vulval development","volume":"18","author":"Sundaram","year":"1996","journal-title":"BioEssays"},{"key":"2025021400104791300_DEVELOP_124_1_243C27","volume-title":"The Nematode Caenorhabditis elegans","author":"Wood","year":"1988"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/124\/1\/243\/3123013\/develop_124_1_243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/124\/1\/243\/3123013\/develop_124_1_243.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T19:11:01Z","timestamp":1739473861000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/124\/1\/243\/39195\/Evolutionary-changes-of-developmental-mechanisms"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.124.1.243","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1,1]]}}}