{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:53:31Z","timestamp":1790891611016,"version":"4.1.0"},"reference-count":44,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The dachshund gene encodes a nuclear protein that is required for normal eye development in Drosophila. In the absence of dachshund function, flies develop with severely reduced or no eyes. We show that targeted expression of dachshund is sufficient to direct ectopic retinal development in a variety of tissues, including the adult head, thorax and legs. This result is similar to that observed with the highly conserved Drosophila gene eyeless, which can induce ectopic eye formation on all major appendages. Here, we show that dachshund and eyeless induce the expression of each other and that dachshund is required for ectopic retinal development driven by eyeless misexpression. These results suggest that the control of eye development requires the complex interaction of multiple genes, even at the very highest regulatory levels.<\/jats:p>","DOI":"10.1242\/dev.124.1.45","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T02:44:11Z","timestamp":1619405051000},"page":"45-52","source":"Crossref","is-referenced-by-count":228,"title":["Ectopic eye development in <i>Drosophila<\/i> induced by directed <i>dachshund<\/i> expression"],"prefix":"10.1242","volume":"124","author":[{"given":"Weiping","family":"Shen","sequence":"first","affiliation":[{"name":"1 Departments of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Mardon","sequence":"additional","affiliation":[{"name":"1 Departments of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"},{"name":"2 Departments of Molecular and Human Genetics and Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"},{"name":"3 Ophthalmology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,1,1]]},"reference":[{"key":"2025021400065380900_DEVELOP_124_1_45C1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/368208a0","article-title":"Compartment boundaries and the control of Drosophila limb pattern by Hedgehog protein","volume":"368","author":"Basler","year":"1994","journal-title":"Nature"},{"key":"2025021400065380900_DEVELOP_124_1_45C2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02100622","article-title":"Molecular evolution in Drosophila and the higher Diptera II. 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