{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:22:43Z","timestamp":1791350563437,"version":"4.3.1"},"reference-count":61,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[1997,8,15]],"date-time":"1997-08-15T00:00:00Z","timestamp":871603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We present the first in vivo study of the long-term fate and potential of early-migrating and late-migrating mesencephalic neural crest cell populations, by performing isochronic and heterochronic quail-to-chick grafts. Both early- and late-migrating populations form melanocytes, neurons, glia, cartilage and bone in isochronic, isotopic chimeras, showing that neither population is lineagerestricted. The early-migrating population distributes both dorsally and ventrally during normal development, while the late-migrating population is confined dorsally and forms much less cartilage and bone. When the latemigrating population is substituted heterochronically for the early-migrating population, it contributes extensively to ventral derivatives such as jaw cartilage and bone. Conversely, when the early-migrating population is substituted heterochronically for the late-migrating population, it no longer contributes to the jaw skeleton and only forms dorsal derivatives. When the late-migrating population is grafted into a late-stage host whose neural crest had previously been ablated, it migrates ventrally into the jaws. Thus, the dorsal fate restriction of the late-migrating mesencephalic neural crest cell population in normal development is due to the presence of earlier-migrating neural crest cells, rather than to any change in the environment or to any intrinsic difference in migratory ability or potential between early- and late-migrating cell populations. These results highlight the plasticity of the neural crest and show that its fate is determined primarily by the environment.<\/jats:p>","DOI":"10.1242\/dev.124.16.3077","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:14:50Z","timestamp":1619205290000},"page":"3077-3087","source":"Crossref","is-referenced-by-count":136,"title":["Early- and late-migrating cranial neural crest cell populations have equivalent developmental potential in vivo"],"prefix":"10.1242","volume":"124","author":[{"given":"Clare V. H.","family":"Baker","sequence":"first","affiliation":[{"name":"Division of Biology 1 , Beckman Institute 139-74, California Institute of Technology, Pasadena, California 91125, USA"},{"name":"Institut d\u2019Embryologie cellulaire et mol\u00e9culaire du CNRS et du Coll\u00e8ge de France 2 , 49bis avenue de la Belle Gabrielle, 94736 Nogent-sur-Marne Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Bronner-Fraser","sequence":"additional","affiliation":[{"name":"Division of Biology 1 , Beckman Institute 139-74, California Institute of Technology, Pasadena, California 91125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M. Le","family":"Douarin","sequence":"additional","affiliation":[{"name":"Institut d\u2019Embryologie cellulaire et mol\u00e9culaire du CNRS et du Coll\u00e8ge de France 2 , 49bis avenue de la Belle Gabrielle, 94736 Nogent-sur-Marne Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Aim\u00e9e","family":"Teillet","sequence":"additional","affiliation":[{"name":"Institut d\u2019Embryologie cellulaire et mol\u00e9culaire du CNRS et du Coll\u00e8ge de France 2 , 49bis avenue de la Belle Gabrielle, 94736 Nogent-sur-Marne Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,8,15]]},"reference":[{"key":"2025021404265868100_DEVELOP_124_16_3077C1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0012-1606(92)90271-H","article-title":"Partial restriction in the developmental potential of late emigrating avian neural crest cells","volume":"149","author":"Artinger","year":"1992","journal-title":"Dev. 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