{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:29:26Z","timestamp":1791224966062,"version":"4.1.0"},"reference-count":81,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Patterning of the non-segmental termini of the Drosophila embryo depends on signalling via the Torso receptor tyrosine kinase (RTK). Activation of Torso at the poles of the embryo triggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb). In this paper, we show that the Groucho (Gro) corepressor acts in this process to confine terminal gap gene expression to the embryonic termini. Embryos lacking maternal gro activity display ectopic tll and hkb transcription; the former leads, in turn, to lack of abdominal expression of the Kr\u00fcppel and knirps gap genes. We show that torso signalling permits terminal gap gene expression by antagonising Gromediated repression. Thus, the corepressor Gro is employed in diverse developmental contexts and, probably, by a variety of DNA-binding repressors.<\/jats:p>","DOI":"10.1242\/dev.124.19.3827","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:00:59Z","timestamp":1619406059000},"page":"3827-3834","source":"Crossref","is-referenced-by-count":76,"title":["Torso signalling regulates terminal patterning in <i>Drosophila<\/i> by antagonising Groucho-mediated repression"],"prefix":"10.1242","volume":"124","author":[{"given":"Ze\u2019ev","family":"Paroush","sequence":"first","affiliation":[{"name":"Imperial Cancer Research Fund, PO Box 123, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Mark","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund, PO Box 123, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ish-Horowicz","sequence":"additional","affiliation":[{"name":"Imperial Cancer Research Fund, PO Box 123, 44 Lincoln\u2019s Inn Fields, London WC2A 3PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,10,1]]},"reference":[{"key":"2025021405031526300_DEVELOP_124_19_3827C1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/387049a0","article-title":"Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression","volume":"387","author":"Alland","year":"1997","journal-title":"Nature"},{"key":"2025021405031526300_DEVELOP_124_19_3827C2","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.1002\/j.1460-2075.1996.tb00735.x","article-title":"The gap protein Knirps mediates both quenching and direct repression in the Drosophila embryo","volume":"15","author":"Arnosti","year":"1996","journal-title":"EMBO J"},{"key":"2025021405031526300_DEVELOP_124_19_3827C3","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/0092-8674(95)90355-0","article-title":"Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3","volume":"80","author":"Ayer","year":"1995","journal-title":"Cell"},{"key":"2025021405031526300_DEVELOP_124_19_3827C4","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.1093\/emboj\/16.10.2883","article-title":"Hairy mediates dominant repression in the Drosophila embryo","volume":"16","author":"Barolo","year":"1997","journal-title":"EMBO J"},{"key":"2025021405031526300_DEVELOP_124_19_3827C5","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1101\/gad.6.11.2137","article-title":"deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product","volume":"6","author":"Bier","year":"1992","journal-title":"Genes Dev"},{"key":"2025021405031526300_DEVELOP_124_19_3827C6","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1101\/gad.5.9.1672","article-title":"Developmental function of Elf-1 \u2013 an essential transcription factor during embryogenesis in Drosophila","volume":"5","author":"Bray","year":"1991","journal-title":"Genes Dev"},{"key":"2025021405031526300_DEVELOP_124_19_3827C7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0925-4773(91)90019-3","article-title":"Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo","volume":"35","author":"Bronner","year":"1991","journal-title":"Mech Dev"},{"key":"2025021405031526300_DEVELOP_124_19_3827C8","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/370386a0","article-title":"The ETS domain protein Pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway","volume":"370","author":"Brunner","year":"1994","journal-title":"Nature"},{"key":"2025021405031526300_DEVELOP_124_19_3827C9","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/0092-8674(94)90362-X","article-title":"A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways","volume":"76","author":"Brunner","year":"1994","journal-title":"Cell"},{"key":"2025021405031526300_DEVELOP_124_19_3827C10","doi-asserted-by":"publisher","first-page":"9309","DOI":"10.1073\/pnas.93.18.9309","article-title":"Long-range repression in the Drosophila embryo","volume":"93","author":"Cai","year":"1996","journal-title":"Proc. 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