{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:16:28Z","timestamp":1789910188086,"version":"4.0.1"},"reference-count":56,"publisher":"The Company of Biologists","issue":"22","license":[{"start":{"date-parts":[[1997,11,15]],"date-time":"1997-11-15T00:00:00Z","timestamp":879552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Targeted disruption of the Hoxd-10 gene, a 5\u2032 member of the mouse HoxD linkage group, produces mice with hindlimb-specific defects in gait and adduction. To determine the underlying causes of this locomotor defect, mutant mice were examined for skeletal, muscular and neural abnormalities. Mutant mice exhibit alterations in the vertebral column and in the bones of the hindlimb. Sacral vertebrae beginning at the level of S2 exhibit homeotic transformations to adopt the morphology of the next most anterior vertebra. In the hindlimb, there is an anterior shift in the position of the patella, an occasional production of an anterior sesamoid bone, and an outward rotation of the lower part of the leg, all of which contribute to the defects in locomotion. No major alterations in hindlimb musculature were observed, but defects in the nervous system were evident. There was a decrease in the number of spinal segments projecting nerve fibers through the sacral plexus to innervate the musculature of the hindlimb. Deletion of a hindlimb nerve was seen in some animals, and a shift was evident in the position of the lumbar lateral motor column. These observations suggest a role for the Hoxd-10 gene in establishing regional identity within the spinal cord and imply that patterning of the spinal cord may have intrinsic components and is not completely imposed by the surrounding mesoderm.<\/jats:p>","DOI":"10.1242\/dev.124.22.4505","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:09:14Z","timestamp":1619406554000},"page":"4505-4514","source":"Crossref","is-referenced-by-count":91,"title":["Targeted disruption of <i>Hoxd-10<\/i> affects mouse hindlimb development"],"prefix":"10.1242","volume":"124","author":[{"given":"Ellen M.","family":"Carpenter","sequence":"first","affiliation":[{"name":"1 Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA 90024, USA"},{"name":"2 Department of Neurobiology, UCLA School of Medicine, Los Angeles, CA 90024, USA"},{"name":"3 Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy M.","family":"Goddard","sequence":"additional","affiliation":[{"name":"3 Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan P.","family":"Davis","sequence":"additional","affiliation":[{"name":"3 Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Paul","family":"Nguyen","sequence":"additional","affiliation":[{"name":"1 Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA 90024, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario R.","family":"Capecchi","sequence":"additional","affiliation":[{"name":"3 Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,11,15]]},"reference":[{"key":"2025022401283253200_DEVELOP_124_22_4505C1","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1242\/dev.122.12.3817","article-title":"Targeted disruption of the hoxb-2 locus in mice interferes with expression of hoxb-1 and hoxb-4","volume":"122","author":"Barrow","year":"1996","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1242\/dev.118.4.1063","article-title":"Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain","volume":"118","author":"Carpenter","year":"1993","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1006\/dbio.1996.8440","article-title":"Targeted mutations in Hoxa-9 and Hoxb-9 reveal synergistic interactions","volume":"181","author":"Chen","year":"1997","journal-title":"Dev. Biol"},{"key":"2025022401283253200_DEVELOP_124_22_4505C4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/350473a0","article-title":"Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene Hox1.5","volume":"350","author":"Chisaka","year":"1991","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C5","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/370304a0","article-title":"Mice with targeted disruptions in the paralogous genes Hoxa-3 and Hoxd-3 reveal synergistic interactions","volume":"370","author":"Condie","year":"1994","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C6","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1242\/dev.120.8.2187","article-title":"Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of Hoxd-11","volume":"120","author":"Davis","year":"1994","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C7","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1242\/dev.122.4.1175","article-title":"A mutational analysis of the 5\u2032 HoxD genes: dissection of genetic interactions during limb development in the mouse","volume":"122","author":"Davis","year":"1996","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C8","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/375791a0","article-title":"Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-11","volume":"375","author":"Davis","year":"1995","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C9","first-page":"2134","article-title":"Location of crossovers during gene targeting with insertion and replacement vectors","volume":"13","author":"Deng","year":"1993","journal-title":"Mol. Cell. Biol"},{"key":"2025022401283253200_DEVELOP_124_22_4505C10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/jez.1400670303","article-title":"An experimental study of spinal nerve segmentation in Amblystoma with reference to the plurisegmental contribution to the brachial plexus","volume":"67","author":"Detweiler","year":"1934","journal-title":"J. Exp. Zool"},{"key":"2025022401283253200_DEVELOP_124_22_4505C11","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1002\/j.1460-2075.1989.tb03535.x","article-title":"Two gene members of the murine HOX-5 complex show regional and cell-type specific expression in developing limbs and gonads","volume":"8","author":"Doll\u00e9","year":"1989","journal-title":"EMBO J"},{"key":"2025022401283253200_DEVELOP_124_22_4505C12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/342767a0","article-title":"Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation","volume":"342","author":"Doll\u00e9","year":"1989","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C13","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/0092-8674(93)90378-4","article-title":"Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs","volume":"75","author":"Doll\u00e9","year":"1993","journal-title":"Cell"},{"key":"2025022401283253200_DEVELOP_124_22_4505C14","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1002\/j.1460-2075.1989.tb03534.x","article-title":"The structural and functional organization of the murine Hox gene family resembles that of Drosophila homeotic genes","volume":"8","author":"Duboule","year":"1989","journal-title":"EMBO J"},{"key":"2025022401283253200_DEVELOP_124_22_4505C15","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0959-437X(05)80072-3","article-title":"Patterning in the vertebral limb","volume":"1","author":"Duboule","year":"1991","journal-title":"Curr. Opin. Genet. Dev"},{"key":"2025022401283253200_DEVELOP_124_22_4505C16","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1242\/dev.1994.Supplement.135","article-title":"Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony","volume":"1994","author":"Duboule","year":"1994","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C17","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1073\/pnas.92.1.310","article-title":"Axial skeleton homeosis and forelimb malformations in Hoxd11 mutant mice","volume":"92","author":"Favier","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025022401283253200_DEVELOP_124_22_4505C18","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1242\/dev.122.2.449","article-title":"Functional cooperation between the non-paralogous genes Hoxa-10 and Hoxd-11 in the developing forelimb and axial skeleton","volume":"122","author":"Favier","year":"1996","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C19","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1242\/dev.122.2.461","article-title":"Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning","volume":"122","author":"Fromental-Ramain","year":"1996","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C20","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1242\/dev.122.10.2997","article-title":"Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod","volume":"122","author":"Fromental-Ramain","year":"1996","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C21","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1242\/dev.122.10.3217","article-title":"Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve","volume":"122","author":"Goddard","year":"1996","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/0092-8674(89)90912-4","article-title":"The murine and Drosophila homeobox gene complexes have common features of organization and expression","volume":"57","author":"Graham","year":"1989","journal-title":"Cell"},{"key":"2025022401283253200_DEVELOP_124_22_4505C23","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1006\/dbio.1993.1145","article-title":"The establishment of murine Hox-1 expression domains during patterning of the limb","volume":"157","author":"Haack","year":"1993","journal-title":"Dev. Biol"},{"key":"2025022401283253200_DEVELOP_124_22_4505C24","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/jez.1400680305","article-title":"The effects of wing bud extirpation on the development of the central nervous system in chick embryos","volume":"68","author":"Hamburger","year":"1934","journal-title":"J. Exp. Zool"},{"key":"2025022401283253200_DEVELOP_124_22_4505C25","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/aja.1001020303","article-title":"Regression versus peripheral control of differentiation in motor hypoplasia","volume":"102","author":"Hamburger","year":"1958","journal-title":"Am. J. Anat"},{"key":"2025022401283253200_DEVELOP_124_22_4505C26","first-page":"39","article-title":"Naturally occurring neuronal death in vertebrates","volume":"1","author":"Hamburger","year":"1982","journal-title":"Neurosci. Comm"},{"key":"2025022401283253200_DEVELOP_124_22_4505C27","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1006\/dbio.1995.1150","article-title":"Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: Evidence for unique and redundant function","volume":"169","author":"Horan","year":"1995","journal-title":"Dev. Biol"},{"key":"2025022401283253200_DEVELOP_124_22_4505C28","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1101\/gad.9.13.1667","article-title":"Compound mutants for the paralogous Hoxa-4, Hoxb-4, and Hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed","volume":"9","author":"Horan","year":"1995","journal-title":"Genes Dev"},{"key":"2025022401283253200_DEVELOP_124_22_4505C29","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1002\/j.1460-2075.1991.tb07764.x","article-title":"Muringe genes related to the Drosophila AbdB hometic gene are sequentially expressed during development of the posterior part of the body","volume":"10","author":"Izpis\u00faa-Belmonte","year":"1991","journal-title":"EMBO J"},{"key":"2025022401283253200_DEVELOP_124_22_4505C30","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/310786a0","article-title":"Segmentation in the vertebrate nervous system","volume":"310","author":"Keynes","year":"1984","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C31","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1242\/dev.122.9.2651","article-title":"Function of posterior HoxD genes in the morphogenesis of the anal sphincter","volume":"122","author":"Kondo","year":"1996","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0092-8674(94)90290-9","article-title":"Hox genes in vertebrate development","volume":"78","author":"Krumlauf","year":"1994","journal-title":"Cell"},{"key":"2025022401283253200_DEVELOP_124_22_4505C33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/cne.902030202","article-title":"Target dependency of developing motoneurons in Xenopus laevis","volume":"203","author":"Lamb","year":"1981","journal-title":"J. Comp. Neurol"},{"key":"2025022401283253200_DEVELOP_124_22_4505C34","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/0165-3806(82)90192-4","article-title":"Motoneuron cell death in the developing lumbar spinal cord of the mouse","volume":"4","author":"Lance-Jones","year":"1982","journal-title":"Dev. Brain Res"},{"key":"2025022401283253200_DEVELOP_124_22_4505C35","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1523\/JNEUROSCI.06-09-02551.1986","article-title":"Survival of motoneurons in the brachial lateral motor column of limbless mutant chick embryos depends on the periphery","volume":"6","author":"Lanser","year":"1986","journal-title":"J. Neurosci"},{"key":"2025022401283253200_DEVELOP_124_22_4505C36","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0092-8674(92)90406-3","article-title":"Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene","volume":"69","author":"LeMouellic","year":"1992","journal-title":"Cell"},{"key":"2025022401283253200_DEVELOP_124_22_4505C37","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/336348a0","article-title":"Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes","volume":"336","author":"Mansour","year":"1988","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1242\/dev.117.1.13","article-title":"Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear","volume":"117","author":"Mansour","year":"1993","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C39","volume-title":"Human Anatomy and Physiology, 3rd Edition","author":"Marieb","year":"1995"},{"key":"2025022401283253200_DEVELOP_124_22_4505C40","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1242\/dev.119.2.319","article-title":"Two rhombomeres are altered in Hoxa-1 mutant mice","volume":"119","author":"Mark","year":"1993","journal-title":"Development"},{"key":"2025022401283253200_DEVELOP_124_22_4505C41","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1098\/rstb.1981.0082","article-title":"The localization of motoneurons supplying the hindlimb muscles of the mouse","volume":"293","author":"McHanwell","year":"1981","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"2025022401283253200_DEVELOP_124_22_4505C42","doi-asserted-by":"publisher","first-page":"8424","DOI":"10.1073\/pnas.90.18.8424","article-title":"Derivation of completely cell culture-derived mice from early-passage embryonic stem cell","volume":"90","author":"Nagy","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025022401283253200_DEVELOP_124_22_4505C43","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/cne.901770107","article-title":"Cell death of motoneurons in the chick embryo spinal cord. III. The differentiation of motoneurons prior to their induced degeneration following limb-bud removal","volume":"177","author":"Oppenheim","year":"1978","journal-title":"J. Comp. Neurol"},{"key":"2025022401283253200_DEVELOP_124_22_4505C44","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1523\/JNEUROSCI.10-08-02699.1990","article-title":"Axon guidance in muscleless chick wings: the role of muscle cells in motoneuronal pathway selection and muscle nerve formation","volume":"10","author":"Phelan","year":"1990","journal-title":"J. Neurosci"},{"key":"2025022401283253200_DEVELOP_124_22_4505C45","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1101\/gad.9.1.108","article-title":"Genetic interaction between Hoxb-5 and Hoxb-6 is revealed by nonallelic noncomplementation","volume":"9","author":"Rancourt","year":"1995","journal-title":"Genes Dev"},{"key":"2025022401283253200_DEVELOP_124_22_4505C46","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1002\/j.1460-2075.1992.tb05190.x","article-title":"Comparison of mouse and human HOX-4 complexes defines conserved sequences involved in the regulation of Hox4.4","volume":"11","author":"Renucci","year":"1992","journal-title":"EMBO J"},{"key":"2025022401283253200_DEVELOP_124_22_4505C47","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/aja.1002010408","article-title":"Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression","volume":"201","author":"Rijli","year":"1994","journal-title":"Dev. Dynamics"},{"key":"2025022401283253200_DEVELOP_124_22_4505C48","doi-asserted-by":"publisher","first-page":"8185","DOI":"10.1073\/pnas.92.18.8185","article-title":"Cryptorchidisn and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice","volume":"92","author":"Rijli","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025022401283253200_DEVELOP_124_22_4505C49","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/374460a0","article-title":"Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice","volume":"374","author":"Satokata","year":"1995","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C50","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/0092-8674(92)90588-4","article-title":"Vertebrate homeobox gene nomenclature","volume":"71","author":"Scott","year":"1992","journal-title":"Cell"},{"key":"2025022401283253200_DEVELOP_124_22_4505C51","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1101\/gad.7.12a.2318","article-title":"Homeotic transformations and limb defects in HoxA-11 mutant mice","volume":"7","author":"Small","year":"1993","journal-title":"Genes Dev"},{"key":"2025022401283253200_DEVELOP_124_22_4505C52","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/384630a0","article-title":"Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1","volume":"384","author":"Studer","year":"1996","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C53","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/0092-8674(87)90646-5","article-title":"Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells","volume":"51","author":"Thomas","year":"1987","journal-title":"Cell"},{"key":"2025022401283253200_DEVELOP_124_22_4505C54","doi-asserted-by":"publisher","first-page":"10251035","DOI":"10.1016\/S0092-8674(00)81303-3","article-title":"Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls","volume":"85","author":"van der Hoeven","year":"1996","journal-title":"Cell"},{"key":"2025022401283253200_DEVELOP_124_22_4505C55","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/384069a0","article-title":"Synpolydactyly in mice with a targeted deficiency in the HoxD complex","volume":"384","author":"Z\u00e1k\u00e1ny","year":"1996","journal-title":"Nature"},{"key":"2025022401283253200_DEVELOP_124_22_4505C56","doi-asserted-by":"publisher","first-page":"4393","DOI":"10.1093\/emboj\/16.14.4393","article-title":"Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum","volume":"16","author":"Z\u00e1k\u00e1ny","year":"1997","journal-title":"EMBO J"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/124\/22\/4505\/3127853\/develop_124_22_4505.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/124\/22\/4505\/3127853\/develop_124_22_4505.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:28:53Z","timestamp":1740360533000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/124\/22\/4505\/39635\/Targeted-disruption-of-Hoxd-10-affects-mouse"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11,15]]},"references-count":56,"journal-issue":{"issue":"22","published-print":{"date-parts":[[1997,11,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.124.22.4505","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11,15]]}}}