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Heregulin-- and ErbB2\u2212\/\u2212 embryos died on E10.5 due to a lack of cardiac ventricular myocyte differentiation; ErbB3-- embryos survived until E13.5 exhibiting cardiac cushion abnormalities leading to blood reflux through defective valves. In ErbB3\u2212\/\u2212 embryos, the midbrain\/hindbrain region was strikingly affected, with little differentiation of the cerebellar plate. Cranial ganglia defects, while present in all three nulls, were less severe in ErbB3\u2212\/\u2212 embryos. The cranial ganglia defects, along with a dramatic reduction in Schwann cells, enteric ganglia and adrenal chromaffin cells, suggests a generalized effect on the neural crest. Numerous organs, including the stomach and pancreas also exhibited anomalous development.<\/jats:p>","DOI":"10.1242\/dev.124.24.4999","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:06:57Z","timestamp":1619406417000},"page":"4999-5011","source":"Crossref","is-referenced-by-count":363,"title":["ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice"],"prefix":"10.1242","volume":"124","author":[{"given":"Sharon L.","family":"Erickson","sequence":"first","affiliation":[{"name":"Department of Molecular Biology 1 , Genentech Inc., Mail Stop 34, South San Francisco, California, 94080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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