{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:39:09Z","timestamp":1791225549810,"version":"4.1.0"},"reference-count":40,"publisher":"The Company of Biologists","issue":"24","license":[{"start":{"date-parts":[[1997,12,15]],"date-time":"1997-12-15T00:00:00Z","timestamp":882144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The cerebral cortex forms by the orderly migration and subsequent differentiation of neuronal precursors generated in the proliferative ventricular zone. We studied the role of the transcription factor Pax-6, which is expressed in the ventricular zone, in cortical development. Embryos homozygous for a mutation of Pax-6 (Small eye; Sey) had abnormalities suggesting defective migration of late-born cortical precursors. When late-born Sey\/Sey precursors were transplanted into wild-type embryonic rat cortex, they showed similar integrative, migrational and differentiative abilities to those of transplanted wild-type mouse precursors. These results suggest that postmitotic cortical cells do not need Pax-6 to acquire the capacity to migrate and differentiate, but that Pax-6 generates a cortical environment that permits later-born precursors to express their full developmental potential.<\/jats:p>","DOI":"10.1242\/dev.124.24.5087","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:07:37Z","timestamp":1619406457000},"page":"5087-5096","source":"Crossref","is-referenced-by-count":120,"title":["Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6"],"prefix":"10.1242","volume":"124","author":[{"given":"Damira","family":"Cari\u0107","sequence":"first","affiliation":[{"name":"MRC Human Genetics Unit, Western General Hospital 1 , Crewe Road, Edinburgh EH4 2XU, UK"},{"name":"University Medical School 2 Department of Physiology , , Teviot Place, Edinburgh EH8 9AG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Gooday","sequence":"additional","affiliation":[{"name":"University Medical School 2 Department of Physiology , , Teviot Place, Edinburgh EH8 9AG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Hill","sequence":"additional","affiliation":[{"name":"MRC Human Genetics Unit, Western General Hospital 1 , Crewe Road, Edinburgh EH4 2XU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"McConnell","sequence":"additional","affiliation":[{"name":"Stanford University 3 Department of Biological Sciences , , Stanford, CA94305-5020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Price","sequence":"additional","affiliation":[{"name":"University Medical School 2 Department of Physiology , , Teviot Place, Edinburgh EH8 9AG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,12,15]]},"reference":[{"key":"2025021408440742000_DEVELOP_124_24_5087C1","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/192766b0","article-title":"Autoradiographic study of cell migration during histogenesis of cerebral cortex in the mouse","volume":"192","author":"Angevine","year":"1961","journal-title":"Nature"},{"key":"2025021408440742000_DEVELOP_124_24_5087C2","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/374719a0","article-title":"A protein related to extracellular matrix proteins deleted in the mouse mutant reeler","volume":"374","author":"D\u2019Arcangelo","year":"1995","journal-title":"Nature"},{"key":"2025021408440742000_DEVELOP_124_24_5087C3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0896-6273(00)80015-X","article-title":"Tempting fate and commitment in the developing forebrain","volume":"16","author":"Barbe","year":"1996","journal-title":"Neuron"},{"key":"2025021408440742000_DEVELOP_124_24_5087C4","volume-title":"Neocortical Development","author":"Bayer","year":"1991"},{"key":"2025021408440742000_DEVELOP_124_24_5087C5","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/0896-6273(95)90007-1","article-title":"Host-guided migration allows targeted introduction of neurons into the embryonic brain","volume":"15","author":"Brustle","year":"1995","journal-title":"Neuron"},{"key":"2025021408440742000_DEVELOP_124_24_5087C6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/jnr.490320407","article-title":"Expression of the class III p-tubulin isotype in the developing neurons in culture","volume":"32","author":"Ferreira","year":"1992","journal-title":"J. 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