{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:59:13Z","timestamp":1769014753032,"version":"3.49.0"},"reference-count":37,"publisher":"The Company of Biologists","issue":"24","license":[{"start":{"date-parts":[[1997,12,15]],"date-time":"1997-12-15T00:00:00Z","timestamp":882144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We have characterized the mau-2 mutants of Caenorhabditis elegans and found that migrating cells and axons are mispositioned along both the antero-posterior and dorso-ventral body axes. This is in contrast to previously characterized guidance mutations in Caenorhabditis and in Drosophila, which have been found to be axis-specific. Two observations suggest that mau-2 acts very early during development: most behavioral phenotypes of mau-2 can be rescued by a maternal effect, and variations in expressivity involve an entire body side at a time. The possibility that mau-2 is involved in the spatial organization of guidance cues encoded by other genes is discussed.<\/jats:p>","DOI":"10.1242\/dev.124.24.5115","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:08:28Z","timestamp":1619406508000},"page":"5115-5126","source":"Crossref","is-referenced-by-count":16,"title":["Cellular and axonal migrations are misguided along both body axes in the maternal-effect <i>mau-2<\/i> mutants of <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1242","volume":"124","author":[{"given":"Shin","family":"Takagi","sequence":"first","affiliation":[{"name":"McGill University 1 Department of Biology , , 1205 Dr Penfield Avenue, Montr\u00e9al, PQ, H3A 1B1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"B\u00e9nard","sequence":"additional","affiliation":[{"name":"McGill University 1 Department of Biology , , 1205 Dr Penfield Avenue, Montr\u00e9al, PQ, H3A 1B1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Pak","sequence":"additional","affiliation":[{"name":"McGill University 1 Department of Biology , , 1205 Dr Penfield Avenue, Montr\u00e9al, PQ, H3A 1B1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Livingstone","sequence":"additional","affiliation":[{"name":"2 Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Hekimi","sequence":"additional","affiliation":[{"name":"McGill University 1 Department of Biology , , 1205 Dr Penfield Avenue, Montr\u00e9al, PQ, H3A 1B1 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1997,12,15]]},"reference":[{"key":"2025021408440615500_DEVELOP_124_24_5115C1","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/386838a0","article-title":"The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein","volume":"386","author":"Ackerman","year":"1997","journal-title":"Nature"},{"key":"2025021408440615500_DEVELOP_124_24_5115C2","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1093\/genetics\/133.4.897","article-title":"The genetics of feeding in Caenorhabditis elegans","volume":"133","author":"Avery","year":"1993","journal-title":"Genetics"},{"key":"2025021408440615500_DEVELOP_124_24_5115C3","doi-asserted-by":"publisher","first-page":"7194","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2025021408440615500_DEVELOP_124_24_5115C4","first-page":"391410","article-title":"Developmental genetics of mechanosensory neurons in Caenorhabditis elegans","volume":"102","author":"Chalfie","year":"1981","journal-title":"Dev. 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