{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:03:51Z","timestamp":1791194631855,"version":"4.1.0"},"reference-count":67,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The DHR3 orphan receptor gene is induced directly by the steroid hormone ecdysone at the onset of Drosophila meta-morphosis. DHR3 expression peaks in early prepupae, as the early puff genes are repressed and \u03b2FTZ-F1 is induced. Here we provide evidence that DHR3 directly contributes to both of these regulatory responses. DHR3 protein is bound to many ecdysone-induced puffs in the polytene chromosomes, including the early puffs that encode the BR-C and E74 regulatory genes, as well as the E75, E78 and \u03b2FTZ-F1 orphan receptor loci. Three DHR3 binding sites were identified downstream from the start site of \u03b2FTZ-F1 transcription, further indicating that this gene is a direct target of DHR3 regulation. Ectopic expression of DHR3 revealed that the polytene chromosome binding pattern is of functional significance. DHR3 is sufficient to repress BR-C, E74A, E75A and E78B transcription as well as induce \u03b2FTZ-F1. DHR3 thus appears to function as a switch that defines the larval-prepupal transition by arresting the early regulatory response to ecdysone at puparium formation and facilitating the induction of the \u03b2FTZ-F1 competence factor in mid-prepupae. This study also provides evidence for direct cross-regulation among orphan members of the nuclear receptor superfamily and further implicates these genes as critical transducers of the hormonal signal during the onset of Drosophila metamorphosis.<\/jats:p>","DOI":"10.1242\/dev.124.9.1757","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T04:08:17Z","timestamp":1619410097000},"page":"1757-1769","source":"Crossref","is-referenced-by-count":155,"title":["Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during <i>Drosophila<\/i> metamorphosis"],"prefix":"10.1242","volume":"124","author":[{"given":"Geanette T.","family":"Lam","sequence":"first","affiliation":[{"name":"University of Utah 1 Howard Hughes Medical Institute , , Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changan","family":"Jiang","sequence":"additional","affiliation":[{"name":"University of Utah 2 Department of Human Genetics, 5200 Eccles Institute of Human Genetics , , Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl S.","family":"Thummel","sequence":"additional","affiliation":[{"name":"University of Utah 1 Howard Hughes Medical Institute , , Salt Lake City, UT 84112, USA"},{"name":"University of Utah 2 Department of Human Genetics, 5200 Eccles Institute of Human Genetics , , Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1997,5,1]]},"reference":[{"key":"2025021402532334100_DEVELOP_124_9_1757C1","first-page":"565","volume-title":"Drosophila melanogaster: Practical Uses in Cell and Molecular Biology","author":"Andres","year":"1994"},{"key":"2025021402532334100_DEVELOP_124_9_1757C2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0012-1606(74)80016-3","article-title":"Sequential gene activation by ecdysone in polytene chromosomes of Drosophila melanogaster. 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