{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:18:18Z","timestamp":1790759898763,"version":"4.1.0"},"reference-count":76,"publisher":"The Company of Biologists","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>Alterations in genes that regulate brain size may contribute to both microcephaly and brain tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor. Cerebellar granule neuron progenitors (CGNPs) express Aspm when maintained in a proliferative state by Sonic Hedgehog (Shh) signaling, and Aspm is expressed in Shh-driven medulloblastoma in mice. Genetic deletion of Aspm reduces cerebellar growth, while paradoxically increasing the mitotic rate of CGNPs. Aspm-deficient CGNPs show impaired mitotic progression, altered patterns of division orientation and differentiation, and increased DNA damage, which causes progenitor attrition through apoptosis. Deletion of Aspm in mice with Smo-induced medulloblastoma reduces tumor growth while increasing DNA damage. Co-deletion of Aspm and either of the apoptosis regulators Bax or Trp53 (p53) rescues the survival of neural progenitors and reduces the growth restriction imposed by Aspm deletion. Our data show that Aspm functions to regulate mitosis and to mitigate DNA damage during CGNP cell division, causes microcephaly through progenitor apoptosis when mutated, and sustains tumor growth in medulloblastoma<\/jats:p>","DOI":"10.1242\/dev.124271","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:59:32Z","timestamp":1444352372000},"source":"Crossref","is-referenced-by-count":37,"title":["Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth"],"prefix":"10.1242","author":[{"given":"Scott E.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idoia","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"Current Affiliation: Neuro-Oncology Group, Biodonostia Institute, San Sebasti\u00e1n, Spain"},{"name":"Current Affiliation: IKERBASQUE, Basque Foundation for Science, Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Crowther","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall J.","family":"Lough","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Veleta","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban A.","family":"Oyarzabal","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Merrill","sequence":"additional","affiliation":[{"name":"Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Yu Ian","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA"},{"name":"Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Gershon","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"},{"name":"UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608123639500_DEV124271C1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1055\/s-0033-1360483","article-title":"Posterior fossa in primary microcephaly: relationships between forebrain and mid-hindbrain size in 110 patients","volume":"45","author":"Adachi","year":"2014","journal-title":"Neuropediatrics"},{"key":"2021042608123639500_DEV124271C2","doi-asserted-by":"publisher","first-page":"E1491","DOI":"10.1073\/pnas.1400568111","article-title":"Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo","volume":"111","author":"Bazzi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608123639500_DEV124271C3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2867-10-1","article-title":"ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target","volume":"10","author":"Bikeye","year":"2010","journal-title":"Cancer Cell Int."},{"key":"2021042608123639500_DEV124271C4","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/ng995","article-title":"ASPM is a major determinant of cerebral cortical size","volume":"32","author":"Bond","year":"2002","journal-title":"Nat. Genet."},{"key":"2021042608123639500_DEV124271C5","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1086\/379085","article-title":"Protein-truncating mutations in ASPM cause variable reduction in brain size","volume":"73","author":"Bond","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"2021042608123639500_DEV124271C6","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1038\/bjc.2011.117","article-title":"ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival","volume":"104","author":"Br\u00fcning-Richardson","year":"2011","journal-title":"Br. J. Cancer"},{"key":"2021042608123639500_DEV124271C7","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1038\/sj.onc.1208350","article-title":"Survivin splice variants regulate the balance between proliferation and cell death","volume":"24","author":"Caldas","year":"2005","journal-title":"Oncogene"},{"key":"2021042608123639500_DEV124271C8","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1073\/pnas.97.2.889","article-title":"Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system","volume":"97","author":"Chong","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608123639500_DEV124271C9","doi-asserted-by":"publisher","first-page":"18098","DOI":"10.1523\/jneurosci.2602-13.2013","article-title":"Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma","volume":"33","author":"Crowther","year":"2013","journal-title":"J. Neurosci."},{"key":"2021042608123639500_DEV124271C10","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1242\/dev.126.14.3089","article-title":"Sonic hedgehog regulates the growth and patterning of the cerebellum","volume":"126","author":"Dahmane","year":"1999","journal-title":"Development"},{"key":"2021042608123639500_DEV124271C11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00401-011-0800-8","article-title":"Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH\/WNT molecular subgroups","volume":"121","author":"Ellison","year":"2011","journal-title":"Acta Neuropathol."},{"key":"2021042608123639500_DEV124271C12","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1523\/JNEUROSCI.5157-07.2008","article-title":"Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cells","volume":"28","author":"Espinosa","year":"2008","journal-title":"J. Neurosci."},{"key":"2021042608123639500_DEV124271C13","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/1526-968X(200011\/12)28:3\/4&lt;106::AID-GENE30&gt;3.0.CO;2-T","article-title":"Widespread recombinase expression using FLPeR (flipper) mice","volume":"28","author":"Farley","year":"2000","journal-title":"Genesis"},{"key":"2021042608123639500_DEV124271C14","doi-asserted-by":"publisher","first-page":"10438","DOI":"10.1073\/pnas.0604066103","article-title":"Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells","volume":"103","author":"Fish","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608123639500_DEV124271C15","doi-asserted-by":"publisher","first-page":"9030","DOI":"10.1038\/sj.onc.1207116","article-title":"Control of apoptosis by p53","volume":"22","author":"Fridman","year":"2003","journal-title":"Oncogene"},{"key":"2021042608123639500_DEV124271C16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1083\/jcb.32.2.277","article-title":"Quantitative analysis of cell proliferation and differentiation in the cortex of the postnatal mouse cerebellum","volume":"32","author":"Fujita","year":"1967","journal-title":"J. Cell Biol."},{"key":"2021042608123639500_DEV124271C17","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1038\/onc.2012.248","article-title":"Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation","volume":"32","author":"Garcia","year":"2012","journal-title":"Oncogene"},{"key":"2021042608123639500_DEV124271C18","doi-asserted-by":"publisher","first-page":"e7491","DOI":"10.1371\/journal.pone.0007491","article-title":"Enteric neural crest differentiation in ganglioneuromas implicates hedgehog signaling in peripheral neuroblastic tumor pathogenesis","volume":"4","author":"Gershon","year":"2009","journal-title":"PLoS ONE"},{"key":"2021042608123639500_DEV124271C19","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/2049-3002-1-15","article-title":"Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum","volume":"1","author":"Gershon","year":"2013","journal-title":"Cancer Metabol."},{"key":"2021042608123639500_DEV124271C20","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1038\/nprot.2010.131","article-title":"Rapid bacterial artificial chromosome modification for large-scale mouse transgenesis","volume":"5","author":"Gong","year":"2010","journal-title":"Nat. Protoc."},{"key":"2021042608123639500_DEV124271C21","doi-asserted-by":"publisher","first-page":"7794","DOI":"10.1158\/0008-5472.CAN-04-1813","article-title":"The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas","volume":"64","author":"Hallahan","year":"2004","journal-title":"Cancer Res."},{"key":"2021042608123639500_DEV124271C22","first-page":"509","article-title":"Biochemistry of granule cell migration in developing mouse cerebellum","volume":"85B","author":"Hatten","year":"1982","journal-title":"Prog. Clin. Biol. Res."},{"key":"2021042608123639500_DEV124271C23","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1158\/0008-5472.CAN-07-5092","article-title":"The Smo\/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread","volume":"68","author":"Hatton","year":"2008","journal-title":"Cancer Res."},{"key":"2021042608123639500_DEV124271C24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1242\/dev.127.6.1185","article-title":"Autoregulation and multiple enhancers control Math1 expression in the developing nervous system","volume":"127","author":"Helms","year":"2000","journal-title":"Development"},{"key":"2021042608123639500_DEV124271C25","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/dneu.20875","article-title":"Development of the cerebellum and cerebellar neural circuits","volume":"72","author":"Hibi","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"2021042608123639500_DEV124271C26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1471-2121-11-85","article-title":"Human ASPM participates in spindle organisation, spindle orientation and cytokinesis","volume":"11","author":"Higgins","year":"2010","journal-title":"BMC Cell Biol."},{"key":"2021042608123639500_DEV124271C27","doi-asserted-by":"publisher","first-page":"17402","DOI":"10.1073\/pnas.0608396103","article-title":"Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target","volume":"103","author":"Horvath","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608123639500_DEV124271C28","doi-asserted-by":"publisher","first-page":"e03297","DOI":"10.7554\/eLife.03297","article-title":"The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation","volume":"3","author":"Houlihan","year":"2014","journal-title":"eLife"},{"key":"2021042608123639500_DEV124271C29","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/ng747","article-title":"Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer","volume":"29","author":"Jonkers","year":"2001","journal-title":"Nat. Genet."},{"key":"2021042608123639500_DEV124271C30","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.pneurobio.2009.11.002","article-title":"Many roads lead to primary autosomal recessive microcephaly","volume":"90","author":"Kaindl","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"2021042608123639500_DEV124271C31","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.3109\/09553002.2011.624152","article-title":"ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy","volume":"87","author":"Kato","year":"2011","journal-title":"Int. J. Radiat. Biol."},{"key":"2021042608123639500_DEV124271C32","doi-asserted-by":"publisher","first-page":"9055","DOI":"10.1128\/MCB.20.23.9055-9067.2000","article-title":"Sonic hedgehog promotes G1 cyclin expression and sustained cell cycle progression in mammalian neuronal precursors","volume":"20","author":"Kenney","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2021042608123639500_DEV124271C33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1242\/dev.00182","article-title":"Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors","volume":"130","author":"Kenney","year":"2003","journal-title":"Development"},{"key":"2021042608123639500_DEV124271C34","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.bbrc.2011.05.056","article-title":"The microcephaly gene aspm is involved in brain development in zebrafish","volume":"409","author":"Kim","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042608123639500_DEV124271C35","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1002\/glia.22392","article-title":"Dicer1 and MiR-9 are required for proper Notch1 signaling and the Bergmann glial phenotype in the developing mouse cerebellum","volume":"60","author":"Kuang","year":"2012","journal-title":"Glia"},{"key":"2021042608123639500_DEV124271C36","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.neuroscience.2006.07.026","article-title":"Responding to DNA double strand breaks in the nervous system","volume":"145","author":"Lee","year":"2007","journal-title":"Neuroscience"},{"key":"2021042608123639500_DEV124271C37","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1038\/emboj.2011.493","article-title":"ATR maintains select progenitors during nervous system development","volume":"31","author":"Lee","year":"2012","journal-title":"EMBO J."},{"key":"2021042608123639500_DEV124271C38","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1158\/1078-0432.CCR-07-5262","article-title":"ASPM is a novel marker for vascular invasion, early recurrence, and poor prognosis of hepatocellular carcinoma","volume":"14","author":"Lin","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"2021042608123639500_DEV124271C39","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1242\/dev.040410","article-title":"Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors","volume":"137","author":"Lizarraga","year":"2010","journal-title":"Development"},{"key":"2021042608123639500_DEV124271C40","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2005.08.028","article-title":"Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors","volume":"48","author":"Machold","year":"2005","journal-title":"Neuron"},{"key":"2021042608123639500_DEV124271C41","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2021042608123639500_DEV124271C42","doi-asserted-by":"publisher","first-page":"10171","DOI":"10.1158\/0008-5472.CAN-06-0657","article-title":"A novel somatic mouse model to survey tumorigenic potential applied to the hedgehog pathway","volume":"66","author":"Mao","year":"2006","journal-title":"Cancer Res."},{"key":"2021042608123639500_DEV124271C43","doi-asserted-by":"publisher","first-page":"e19419","DOI":"10.1371\/journal.pone.0019419","article-title":"In vivo fate analysis reveals the multipotent and self-renewal features of embryonic AspM expressing cells","volume":"6","author":"Marinaro","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042608123639500_DEV124271C44","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/dvdy.20551","article-title":"Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit","volume":"234","author":"Matei","year":"2005","journal-title":"Dev. Dyn."},{"key":"2021042608123639500_DEV124271C45","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/1471-2148-14-120","article-title":"Microcephaly genes evolved adaptively throughout the evolution of eutherian mammals","volume":"14","author":"Montgomery","year":"2014","journal-title":"BMC Evol. Biol."},{"key":"2021042608123639500_DEV124271C46","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/dvdy.24276","article-title":"Cerebellar granule cells are predominantly generated by terminal symmetric divisions of granule cell precursors","volume":"244","author":"Nakashima","year":"2015","journal-title":"Dev. Dyn."},{"key":"2021042608123639500_DEV124271C47","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1200\/JCO.2009.27.4324","article-title":"Medulloblastoma comprises four distinct molecular variants","volume":"29","author":"Northcott","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"2021042608123639500_DEV124271C48","doi-asserted-by":"publisher","first-page":"130065","DOI":"10.1098\/rsob.130065","article-title":"Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression","volume":"3","author":"Novorol","year":"2013","journal-title":"Open Biol."},{"key":"2021042608123639500_DEV124271C49","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.4161\/cc.6.13.4356","article-title":"ASPM and citron kinase co-localize to the midbody ring during cytokinesis","volume":"6","author":"Paramasivam","year":"2007","journal-title":"Cell Cycle"},{"key":"2021042608123639500_DEV124271C50","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1093\/hmg\/ddn144","article-title":"Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination","volume":"17","author":"Pawlisz","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2021042608123639500_DEV124271C51","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.devcel.2014.08.007","article-title":"Acentrosomal Drosophila epithelial cells exhibit abnormal cell division, leading to cell death and compensatory proliferation","volume":"30","author":"Poulton","year":"2014","journal-title":"Dev. Cell"},{"key":"2021042608123639500_DEV124271C52","doi-asserted-by":"publisher","first-page":"16595","DOI":"10.1073\/pnas.1010494107","article-title":"Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline","volume":"107","author":"Pulvers","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608123639500_DEV124271C53","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1242\/jcs.115.5.913","article-title":"A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila","volume":"115","author":"Riparbelli","year":"2002","journal-title":"J. Cell Sci."},{"key":"2021042608123639500_DEV124271C54","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/B978-0-12-380916-2.00008-5","article-title":"Cerebellum: development and medulloblastoma","volume":"94","author":"Roussel","year":"2011","journal-title":"Curr. Top. Dev. Biol."},{"key":"2021042608123639500_DEV124271C55","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1038\/nrd2086","article-title":"Targeting the Hedgehog pathway in cancer","volume":"5","author":"Rubin","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"2021042608123639500_DEV124271C56","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/ncb2858","article-title":"The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II","volume":"15","author":"Rujano","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"2021042608123639500_DEV124271C57","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1083\/jcb.137.4.881","article-title":"The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle","volume":"137","author":"Saunders","year":"1997","journal-title":"J. Cell Biol."},{"key":"2021042608123639500_DEV124271C58","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s00418-008-0483-y","article-title":"Besides Purkinje cells and granule neurons: an appraisal of the cell biology of the interneurons of the cerebellar cortex","volume":"130","author":"Schilling","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"2021042608123639500_DEV124271C59","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ccr.2008.07.005","article-title":"Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma","volume":"14","author":"Sch\u00fcller","year":"2008","journal-title":"Cancer Cell"},{"key":"2021042608123639500_DEV124271C60","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nn.2527","article-title":"The exon junction complex component Magoh controls brain size by regulating neural stem cell division","volume":"13","author":"Silver","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2021042608123639500_DEV124271C61","doi-asserted-by":"publisher","first-page":"11272","DOI":"10.1073\/pnas.0504783102","article-title":"Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease","volume":"102","author":"Takeuchi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608123639500_DEV124271C62","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/ncb1834","article-title":"NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5\/GPR\/Galpha","volume":"11","author":"van der Voet","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"2021042608123639500_DEV124271C63","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nrc864","article-title":"Live or let die: the cell's response to p53","volume":"2","author":"Vousden","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"2021042608123639500_DEV124271C64","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00381-010-1252-5","article-title":"ASPM gene expression in medulloblastoma","volume":"27","author":"Vulcani-Freitas","year":"2011","journal-title":"Childs Nerv. Syst."},{"key":"2021042608123639500_DEV124271C65","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1083\/jcb.153.4.637","article-title":"The Drosophila protein Asp is involved in microtubule organization during spindle formation and cytokinesis","volume":"153","author":"Wakefield","year":"2001","journal-title":"J. Cell Biol."},{"key":"2021042608123639500_DEV124271C66","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1053\/j.gastro.2013.07.040","article-title":"A gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumor progression","volume":"145","author":"Wang","year":"2013","journal-title":"Gastroenterology"},{"key":"2021042608123639500_DEV124271C67","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0896-6273(00)80682-0","article-title":"Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog","volume":"22","author":"Wechsler-Reya","year":"1999","journal-title":"Neuron"},{"key":"2021042608123639500_DEV124271C68","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nature09793","article-title":"Asymmetric cell divisions promote Notch-dependent epidermal differentiation","volume":"470","author":"Williams","year":"2011","journal-title":"Nature"},{"key":"2021042608123639500_DEV124271C69","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1086\/429930","article-title":"Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings","volume":"76","author":"Woods","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"2021042608123639500_DEV124271C70","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ccr.2008.07.003","article-title":"Medulloblastoma can be initiated by deletion of patched in lineage-restricted progenitors or stem cells","volume":"14","author":"Yang","year":"2008","journal-title":"Cancer Cell"},{"key":"2021042608123639500_DEV124271C71","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"Neuroimage"},{"key":"2021042608123639500_DEV124271C72","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/0361-9230(87)90010-4","article-title":"The location and orientation of mitotic figures during histogenesis of the rat cerebellar cortex","volume":"18","author":"Zagon","year":"1987","journal-title":"Brain Res. Bull."},{"key":"2021042608123639500_DEV124271C73","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.4161\/cc.4.9.2029","article-title":"The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein","volume":"4","author":"Zhong","year":"2005","journal-title":"Cell Cycle"},{"key":"2021042608123639500_DEV124271C74","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/gene.10008","article-title":"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo","volume":"31","author":"Zhuo","year":"2001","journal-title":"Genesis"},{"key":"2021042608123639500_DEV124271C75","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/(SICI)1098-2264(200005)28:1&lt;77::AID-GCC9&gt;3.0.CO;2-Y","article-title":"Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice","volume":"28","author":"Zurawel","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"2021042608123639500_DEV124271C76","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/(SICI)1098-2264(200001)27:1&lt;44::AID-GCC6&gt;3.0.CO;2-V","article-title":"Analysis of PTCH\/SMO\/SHH pathway genes in medulloblastoma","volume":"27","author":"Zurawel","year":"2000","journal-title":"Genes Chromosomes Cancer"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/142\/22\/3921\/1839988\/dev124271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.124271\/2033597\/dev_124271v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.124271\/2033597\/dev_124271v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T20:49:28Z","timestamp":1621370968000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/doi\/10.1242\/dev.124271\/256886\/Aspm-sustains-postnatal-cerebellar-neurogenesis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":76,"URL":"https:\/\/doi.org\/10.1242\/dev.124271","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]},"article-number":"dev.124271"}}