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Epigenetic modulators are central to precisely coordinating developmental events, and many epigenetic processes have been implicated in cancer. Studying epigenetic mechanisms in development is challenging because they often regulate multiple cellular processes; therefore, elucidating the primary molecular mechanisms involved can be difficult. Here we explore the role of Brg1 (Smarca4) in retinal development and retinoblastoma in mice using molecular and cellular approaches. Brg1 was found to regulate retinal size by controlling cell cycle length, cell cycle exit and cell survival during development. Brg1 was not required for cell fate specification but was required for photoreceptor differentiation and cell adhesion\/polarity programs that contribute to proper retinal lamination during development. The combination of defective cell differentiation and lamination led to retinal degeneration in Brg1-deficient retinae. Despite the hypocellularity, premature cell cycle exit, increased cell death and extended cell cycle length, retinal progenitor cells persisted in Brg1-deficient retinae, making them more susceptible to retinoblastoma. ChIP-Seq analysis suggests that Brg1 might regulate gene expression through multiple mechanisms.<\/jats:p>","DOI":"10.1242\/dev.124800","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T12:37:45Z","timestamp":1448973465000},"page":"4092-4106","source":"Crossref","is-referenced-by-count":34,"title":["Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma"],"prefix":"10.1242","volume":"142","author":[{"given":"Issam","family":"Aldiri","sequence":"first","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuki","family":"Ajioka","sequence":"additional","affiliation":[{"name":"Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beisi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Benavente","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Lawrence Berkeley National Laboratory, Genomics Division, Berkeley, CA 94701, USA"},{"name":"Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Len A.","family":"Pennacchio","sequence":"additional","affiliation":[{"name":"Lawrence Berkeley National Laboratory, Genomics Division, Berkeley, CA 94701, USA"},{"name":"Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Dyer","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA"},{"name":"Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA"},{"name":"Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608150878400_DEV124800C1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.cell.2007.09.036","article-title":"Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice","volume":"131","author":"Ajioka","year":"2007","journal-title":"Cell"},{"key":"2021042608150878400_DEV124800C2","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1242\/dev.109496","article-title":"Brg1 modulates enhancer activation in mesoderm lineage commitment","volume":"142","author":"Alexander","year":"2015","journal-title":"Development"},{"key":"2021042608150878400_DEV124800C3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/(SICI)1097-0177(199603)205:3&lt;293::AID-AJA9&gt;3.0.CO;2-D","article-title":"Quantitative analysis of proliferation and cell cycle length during development of the rat retina","volume":"205","author":"Alexiades","year":"1996","journal-title":"Dev. 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