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Embryos mutant for a deletion of syu display defects in patterning of the somites, the lateral floor plate cells, the pectoral fins, the axons of motorneurons and the retinal ganglion cells. In contrast to mouse embryos lacking Shh activity, syu mutant embryos do form medial floor plate cells and motorneurons. Since ectopic overexpression of shh in zebrafish embryos does not induce ectopic medial floor plate cells, we conclude that shh is neither required nor sufficient to induce this cell type in the zebrafish.<\/jats:p>","DOI":"10.1242\/dev.125.15.2983","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:21:46Z","timestamp":1619407306000},"page":"2983-2993","source":"Crossref","is-referenced-by-count":305,"title":["<i>Sonic hedgehog<\/i> is not required for the induction of medial floor plate cells in the zebrafish"],"prefix":"10.1242","volume":"125","author":[{"given":"Heike E.","family":"Schauerte","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, Spemannstrasse 35\/III, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredericus J. M. van","family":"Eeden","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, Spemannstrasse 35\/III, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Fricke","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, Spemannstrasse 35\/III, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Odenthal","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, Spemannstrasse 35\/III, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Str\u00e4hle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Haffter","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, Spemannstrasse 35\/III, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1998,8,1]]},"reference":[{"key":"2025021501301082500_DEVELOP_125_15_2983C1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/cne.903260208","article-title":"Axonal trajectories and distribution of GABAergic spinal neurons in wildtype and mutant zebrafish lacking floor plate cells","volume":"326","author":"Bernhardt","year":"1992","journal-title":"J. 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