{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:21:40Z","timestamp":1790965300039,"version":"4.1.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[1998,8,15]],"date-time":"1998-08-15T00:00:00Z","timestamp":903139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We have used a LIN-12::GFP fusion protein to examine LIN-12 accumulation during cell fate decisions important for vulval development. During the naturally variable anchor cell (AC)\/ventral uterine precursor cell (VU) decision of the somatic gonad, a transcription-based feedback mechanism biases two equivalent cells so that one becomes the AC while the other becomes a VU. LIN-12::GFP accumulation reflects lin-12 transcription: LIN-12::GFP is initially present in both cells, but disappears from the presumptive AC and becomes restricted to the presumptive VU. During vulval precursor cell (VPC) fate determination, six equipotential cells uniformly transcribe lin-12 and have invariant fates that are specified by multiple cell-cell interactions. The pattern of LIN-12::GFP accumulation in VPCs and in the VPC lineages is dynamic and does not always reflect lin-12 transcription. In particular, LIN-12::GFP is expressed initially in all six VPCs, but appears to be reduced specifically in P6.p as a consequence of the activation of the Ras pathway by an EGF-like inductive signal from the AC. We propose that downregulation of LIN-12 stability or translation in response to inductive signalling helps impose a bias on lateral signalling and contributes to the invariant pattern of VPC fates.<\/jats:p>","DOI":"10.1242\/dev.125.16.3101","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:23:40Z","timestamp":1619407420000},"page":"3101-3109","source":"Crossref","is-referenced-by-count":57,"title":["LIN-12 protein expression and localization during vulval development in <i>C. elegans<\/i>"],"prefix":"10.1242","volume":"125","author":[{"given":"Diane","family":"Levitan","sequence":"first","affiliation":[{"name":"1 Department of Biochemistry and Molecular Biophysics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Greenwald","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry and Molecular Biophysics"},{"name":"2 Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1998,8,15]]},"reference":[{"key":"2025021501323377400_DEVELOP_125_16_3101C1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/348693a0","article-title":"The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily","volume":"348","author":"Aroian","year":"1990","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/genetics\/128.2.251","article-title":"Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction","volume":"128","author":"Aroian","year":"1991","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C3","first-page":"565","volume-title":"Transcript analysis of glp-1 and lin-12","author":"Austin","year":"1989"},{"key":"2025021501323377400_DEVELOP_125_16_3101C4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/348503a0","article-title":"Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction","volume":"348","author":"Beitel","year":"1990","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C5","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1242\/dev.122.8.2517","article-title":"Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development","volume":"122","author":"Bettinger","year":"1996","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C7","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1073\/pnas.94.6.2433","article-title":"egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans","volume":"94","author":"Burdine","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021501323377400_DEVELOP_125_16_3101C8","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1242\/dev.125.6.1083","article-title":"EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans","volume":"125","author":"Burdine","year":"1998","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C9","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1126\/science.8303295","article-title":"Green fluorescent protein as a marker for gene expression","volume":"263","author":"Chalfie","year":"1994","journal-title":"Science"},{"key":"2025021501323377400_DEVELOP_125_16_3101C10","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0092-8674(94)90311-5","article-title":"Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo","volume":"77","author":"Evans","year":"1994","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0092-8674(90)90534-L","article-title":"Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila","volume":"61","author":"Fehon","year":"1990","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.113.3.657","article-title":"Complex cellular and subcellular regulation of Notch expression during embryonic and imaginal development of Drosophila: implications for Notch function","volume":"113","author":"Fehon","year":"1991","journal-title":"J. Cell Biol"},{"key":"2025021501323377400_DEVELOP_125_16_3101C13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/genetics\/110.1.17","article-title":"Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans","volume":"110","author":"Ferguson","year":"1985","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/326259a0","article-title":"A genetic pathway for the specification of the vulval lineages of Caenorhabditis elegans","volume":"326","author":"Ferguson","year":"1987","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C15","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1242\/dev.119.4.1019","article-title":"glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans","volume":"119","author":"Fitzgerald","year":"1993","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C16","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1242\/dev.122.6.1673","article-title":"Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling","volume":"122","author":"Gho","year":"1996","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0896-6273(00)80278-0","article-title":"Control of daughter cell fates during asymmetric division: interaction of Numb and Notch","volume":"17","author":"Guo","year":"1996","journal-title":"Neuron"},{"key":"2025021501323377400_DEVELOP_125_16_3101C18","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1242\/dev.124.3.637","article-title":"Structure, function and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans","volume":"124","author":"Grant","year":"1997","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C19","first-page":"519","volume-title":"C. elegans II","author":"Greenwald","year":"1997"},{"key":"2025021501323377400_DEVELOP_125_16_3101C20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/346197a0","article-title":"Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans","volume":"346","author":"Greenwald","year":"1990","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0092-8674(83)90377-X","article-title":"The lin-12 locus specifies cell fates in Caenorhabditis elegans","volume":"34","author":"Greenwald","year":"1983","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C22","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/genetics\/126.4.899","article-title":"The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans","volume":"126","author":"Han","year":"1990","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0092-8674(90)90495-Z","article-title":"Let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein","volume":"63","author":"Han","year":"1990","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/genetics\/141.3.989","article-title":"The ncl-1 gene and genetic mosaics of Caenorhbaditis elegans","volume":"141","author":"Hedgecock","year":"1995","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C25","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1242\/dev.117.3.1113","article-title":"Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions","volume":"117","author":"Heitzler","year":"1993","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C26","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1242\/dev.120.10.2913","article-title":"lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans","volume":"120","author":"Henderson","year":"1994","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/348169a0","article-title":"Limitation of the size of the vulval primordium of Caenorhabditis elegans by lin-15 expression in the surrounding hypodermis","volume":"348","author":"Herman","year":"1990","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C28","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/358470a0","article-title":"The gene lin-3 encodes an inductive signal for vulval development in C. elegans","volume":"358","author":"Hill","year":"1992","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/genetics\/91.1.67","article-title":"Nondisjunction mutants of the nematode Caenorhabditis elegans","volume":"91","author":"Hodgkin","year":"1979","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1242\/dev.122.1.97","article-title":"The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins","volume":"122","author":"Hoskins","year":"1996","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C31","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1101\/gad.11.23.3182","article-title":"sel-10, a negative regulator of lin-12 activity in C. elegans, encodes a member of the CDC4 family of proteins","volume":"11","author":"Hubbard","year":"1997","journal-title":"Genes Dev"},{"key":"2025021501323377400_DEVELOP_125_16_3101C32","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0955-0674(97)80090-7","article-title":"Dorsal-ventral signalling in limb development","volume":"9","author":"Irvine","year":"1997","journal-title":"Curr. Opin. Cell Biol"},{"key":"2025021501323377400_DEVELOP_125_16_3101C33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0896-6273(95)90235-X","article-title":"Maggot\u2019s hair and bug\u2019s eye: role of cell interactions and intrinsic factors in cell fate specification","volume":"14","author":"Jan","year":"1995","journal-title":"Neuron"},{"key":"2025021501323377400_DEVELOP_125_16_3101C34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0092-8674(95)90317-8","article-title":"Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates","volume":"82","author":"Katz","year":"1995","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0012-1606(79)90035-6","article-title":"The post-embryonic cell lineages of the hermaphrodites and male gonads in Caenorhabditis elegans","volume":"87","author":"Kimble","year":"1979","journal-title":"Dev. Biol"},{"key":"2025021501323377400_DEVELOP_125_16_3101C36","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0012-1606(81)90152-4","article-title":"Alteration in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans","volume":"87","author":"Kimble","year":"1981","journal-title":"Dev. Biol"},{"key":"2025021501323377400_DEVELOP_125_16_3101C37","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1242\/dev.121.8.2655","article-title":"Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans","volume":"121","author":"Koga","year":"1995","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dev.112.1.231","article-title":"Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions","volume":"112","author":"Lambie","year":"1991","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/377351a0","article-title":"Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer\u2019s disease gene","volume":"377","author":"Levitan","year":"1995","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C40","first-page":"452","volume-title":"Caenorhabditis elegans","author":"Mello","year":"1995"},{"key":"2025021501323377400_DEVELOP_125_16_3101C41","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J"},{"key":"2025021501323377400_DEVELOP_125_16_3101C42","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1242\/dev.121.2.263","article-title":"The C. elegans lin-12 gene mediates induction of ventral uterine specialization by the anchor cell","volume":"121","author":"Newman","year":"1995","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0012-1606(86)90358-1","article-title":"C. elegans morphogenesis: The role of the cytoskeleton in elongation of the embryo","volume":"117","author":"Priess","year":"1986","journal-title":"Dev. Biol"},{"key":"2025021501323377400_DEVELOP_125_16_3101C44","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0092-8674(89)90060-3","article-title":"Cell autonomy of lin-12 function in a cell fate decision in C. elegans","volume":"57","author":"Seydoux","year":"1989","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C45","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1242\/dev.124.17.3363","article-title":"Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation","volume":"124","author":"Sherwood","year":"1997","journal-title":"Development"},{"key":"2025021501323377400_DEVELOP_125_16_3101C46","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/375142a0","article-title":"Sequential signalling during Caenorhabditis elegansvulval induction","volume":"375","author":"Simske","year":"1995","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C47","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0092-8674(00)81096-X","article-title":"LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction","volume":"85","author":"Simske","year":"1996","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C48","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0896-6273(95)90088-8","article-title":"A collection of cortical crescents: asymmetric protein localization in CNS precursor cells","volume":"15","author":"Spana","year":"1995","journal-title":"Neuron"},{"key":"2025021501323377400_DEVELOP_125_16_3101C49","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/335551a0","article-title":"Lateral inhibition during vulval induction in Caenorhabditis elegans","volume":"335","author":"Sternberg","year":"1988","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C50","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(86)90842-1","article-title":"Pattern formation during vulval development in C. elegans","volume":"44","author":"Sternberg","year":"1986","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C51","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(89)90103-7","article-title":"The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans","volume":"58","author":"Sternberg","year":"1989","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C52","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Postembryonic lineages of the nematode Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol"},{"key":"2025021501323377400_DEVELOP_125_16_3101C53","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0012-1606(80)90353-X","article-title":"Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans","volume":"78","author":"Sulston","year":"1980","journal-title":"Dev. Biol"},{"key":"2025021501323377400_DEVELOP_125_16_3101C54","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/368150a0","article-title":"Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila","volume":"368","author":"Tax","year":"1994","journal-title":"Nature"},{"key":"2025021501323377400_DEVELOP_125_16_3101C55","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/genetics\/147.4.1675","article-title":"Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans","volume":"147","author":"Tax","year":"1997","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C56","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1101\/gad.9.3.341","article-title":"lin-25, a gene required for vulval induction in Caenorhabditis elegans","volume":"9","author":"Tuck","year":"1995","journal-title":"Genes Dev"},{"key":"2025021501323377400_DEVELOP_125_16_3101C57","doi-asserted-by":"crossref","first-page":"11823","DOI":"10.1101\/gad.3.12a.1823","article-title":"The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types","volume":"3","author":"Way","year":"1989","journal-title":"Genes Dev"},{"key":"2025021501323377400_DEVELOP_125_16_3101C58","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0092-8674(94)90010-8","article-title":"Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision","volume":"79","author":"Wilkinson","year":"1994","journal-title":"Cell"},{"key":"2025021501323377400_DEVELOP_125_16_3101C59","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/genetics\/141.2.513","article-title":"Spatial and temporal patterns of lin-12 expression during C. elegans hermaphrodite development","volume":"141","author":"Wilkinson","year":"1995","journal-title":"Genetics"},{"key":"2025021501323377400_DEVELOP_125_16_3101C60","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1242\/dev.124.10.1887","article-title":"Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis","volume":"124","author":"Zhong","year":"1997","journal-title":"Development"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/16\/3101\/3139160\/develop_125_16_3101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/16\/3101\/3139160\/develop_125_16_3101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T01:32:56Z","timestamp":1739583176000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/125\/16\/3101\/39965\/LIN-12-protein-expression-and-localization-during"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8,15]]},"references-count":60,"journal-issue":{"issue":"16","published-print":{"date-parts":[[1998,8,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.125.16.3101","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8,15]]}}}