{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:00:19Z","timestamp":1791039619651,"version":"4.1.0"},"reference-count":68,"publisher":"The Company of Biologists","issue":"18","license":[{"start":{"date-parts":[[1998,9,15]],"date-time":"1998-09-15T00:00:00Z","timestamp":905817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In C. elegans, the epithelial Pn.p cells adopt either a vulval precursor cell fate or fuse with the surrounding hypodermis (the F fate). Our results suggest that a Wnt signal transduced through a pathway involving the \u03b2-catenin homolog BAR-1 controls whether P3.p through P8.p adopt the vulval precursor cell fate. In bar-1 mutants, P3.p through P8.p can adopt F fates instead of vulval precursor cell fates. The Wnt\/bar-1 signaling pathway acts by regulating the expression of the Hox gene lin-39, since bar-1 is required for LIN-39 expression and forced lin-39 expression rescues the bar-1 mutant phenotype. LIN-39 activity is also regulated by the anchor cell signal\/let-23 receptor tyrosine kinase\/let-60 Ras signaling pathway. Our genetic and molecular experiments show that the vulval precursor cells can integrate the input from the BAR-1 and LET-60 Ras signaling pathways by coordinately regulating activity of the common target LIN-39 Hox.<\/jats:p>","DOI":"10.1242\/dev.125.18.3667","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T23:21:58Z","timestamp":1619392918000},"page":"3667-3680","source":"Crossref","is-referenced-by-count":211,"title":["The \u03b2-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene\n                    <i>lin-39<\/i>\n                    during\n                    <i>Caenorhabditis elegans<\/i>\n                    vulval development"],"prefix":"10.1242","volume":"125","author":[{"given":"David M.","family":"Eisenmann","sequence":"first","affiliation":[{"name":"Stanford University 1 Department of Developmental Biology , , Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julin N.","family":"Maloof","sequence":"additional","affiliation":[{"name":"University of California 2 Department of Biochemistry and Biophysics , , San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Simske","sequence":"additional","affiliation":[{"name":"Stanford University 1 Department of Developmental Biology , , Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Kenyon","sequence":"additional","affiliation":[{"name":"University of California 2 Department of Biochemistry and Biophysics , , San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Stanford University 1 Department of Developmental Biology , , Stanford, CA 94305, 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