{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:38:35Z","timestamp":1790271515465,"version":"4.1.0"},"reference-count":65,"publisher":"The Company of Biologists","issue":"18","license":[{"start":{"date-parts":[[1998,9,15]],"date-time":"1998-09-15T00:00:00Z","timestamp":905817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>All cranial nerves, as well as the VIIIth nerve which invades the cochlea, have a proximal end in which myelin is formed by Schwann cells and a distal end which is surrounded by oligodendrocytes. The question which arises in this context is whether peripheral and central parts of these nerves myelinate simultaneously or subsequently and whether the myelination of either of the parts occurs simultaneously at the onset of the cochlea function and under the control of neuronal activity. In the present paper, we examined the relative time course of the myelinogenesis of the distal part of the VIIIth nerve by analyzing the expression of peripheral protein P0, proteolipid protein and myelin basic protein. To our surprise, we observed that the expression of myelin markers in the peripheral and central part of the intradural part of the VIIIth nerve started simultaneously, from postnatal day 2 onwards, long before the onset of cochlea function. The expression rapidly achieved saturation levels on the approach to postnatal day 12, the day on which the cochlea function commenced. Because of its importance for the neuronal and morphological maturation of the cochlea during this time, an additional role of thyroid hormone in cochlear myelinogenesis was considered. Indeed, it transpires that this hormone ensures the rapid accomplishment of glial gene expression, not only in the central but also in the peripheral part of the cochlea. Furthermore, an analysis of the thyroid hormone receptors, TR\u03b1 and TR\u03b2, indicates that TR\u03b2 is necessary for myelinogenesis of the VIIIth nerve. Rapid thyroid hormone-dependent saturation of myelin marker gene expression in Schwann cells and oligodendrocytes of the VIIIth nerve may guarantee nerve conduction and synchronized impulse transmission at the onset of hearing. The thyroid hormone-dependent commencement of nerve conduction is discussed in connection with the patterning refinement of central auditory pathways and the acquisition of deafness.<\/jats:p>","DOI":"10.1242\/dev.125.18.3709","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T23:21:38Z","timestamp":1619392898000},"page":"3709-3718","source":"Crossref","is-referenced-by-count":104,"title":["Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function"],"prefix":"10.1242","volume":"125","author":[{"given":"Marlies","family":"Knipper","sequence":"first","affiliation":[{"name":"University of T\u00fcbingen 1 , Department of Oto-Rhino-Laryngology, T\u00fcbingen Centre for Hearing Research, R\u00f6ntgenweg 11, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bandtlow","sequence":"additional","affiliation":[{"name":"University of Zurich 2 , Department of Brain Research, August Forei Strasse 1, 8029 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lika","family":"Gestwa","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen 1 , Department of Oto-Rhino-Laryngology, T\u00fcbingen Centre for Hearing Research, R\u00f6ntgenweg 11, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"K\u00f6pschall","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen 1 , Department of Oto-Rhino-Laryngology, T\u00fcbingen Centre for Hearing Research, R\u00f6ntgenweg 11, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Rohbock","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen 1 , Department of Oto-Rhino-Laryngology, T\u00fcbingen Centre for Hearing Research, R\u00f6ntgenweg 11, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Wiechers","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen 1 , Department of Oto-Rhino-Laryngology, T\u00fcbingen Centre for Hearing Research, R\u00f6ntgenweg 11, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Zenner","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen 1 , Department of Oto-Rhino-Laryngology, T\u00fcbingen Centre for Hearing Research, R\u00f6ntgenweg 11, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"University of T\u00fcbingen 1 , Department of Oto-Rhino-Laryngology, T\u00fcbingen Centre for Hearing Research, R\u00f6ntgenweg 11, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1998,9,15]]},"reference":[{"key":"2025021501572872900_DEVELOP_125_18_3709C1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1460-9568.1993.tb00499.x","article-title":"Changes in nuclear 3, 5, 3\u2032-triiodothyronine receptor expression in rat dorsal root ganglia and sciatic nerve during development: comparison with regeneration","volume":"4","author":"Barakat-Walter, Duc","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"2025021501572872900_DEVELOP_125_18_3709C2","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1530\/eje.0.1330390","article-title":"Thyroid hormones and brain development","volume":"133","author":"Bernal","year":"1995","journal-title":"Eur. J. Endocrin."},{"key":"2025021501572872900_DEVELOP_125_18_3709C3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/thy.1993.3.59","article-title":"Endemic cretinism: Toward a unifying hypothesis","volume":"3","author":"Boyages","year":"1993","journal-title":"Thyroid"},{"key":"2025021501572872900_DEVELOP_125_18_3709C4","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1073\/pnas.91.2.439","article-title":"Thyroid hormone receptor (TR). gene expression during auditory neurogenesis: Evidence for TR isoform-specific transcriptional regulation in vivo","volume":"91","author":"Bradley","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021501572872900_DEVELOP_125_18_3709C5","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/neu.480110403","article-title":"Synthesis of the myelin proteolipid in developing mouse brain","volume":"11","author":"Campagnoni","year":"1980","journal-title":"J. Neurobiol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C6","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1083\/jcb.106.4.1281","article-title":"Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading","volume":"106","author":"Caroni","year":"1988","journal-title":"J. Cell. Biol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C7","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/0012-1606(84)90162-3","article-title":"Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes","volume":"101","author":"Cox","year":"1984","journal-title":"Dev. Biol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C8","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/0959-4388(95)80094-8","article-title":"Activity-dependent remodeling of connections in the mammalian visual system","volume":"5","author":"Cramer","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C9","doi-asserted-by":"publisher","first-page":"9887","DOI":"10.1073\/pnas.93.18.9887","article-title":"Induction of myelination in the central nervous system by electrical activity","volume":"93","author":"Demerens","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021501572872900_DEVELOP_125_18_3709C10","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1146\/annurev.ph.49.030187.001541","article-title":"Thyroid hormones and brain development","volume":"49","author":"Dussault","year":"1987","journal-title":"Annu. Rev. Physiol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C11","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1210\/endo.131.5.1425440","article-title":"Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform","volume":"131","author":"Falcone","year":"1992","journal-title":"Endocrinology,"},{"key":"2025021501572872900_DEVELOP_125_18_3709C12","doi-asserted-by":"publisher","first-page":"15784","DOI":"10.1016\/S0021-9258(19)49603-8","article-title":"Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter","volume":"267","author":"Farsetti","year":"1992","journal-title":"J. Biol. Chem."},{"key":"2025021501572872900_DEVELOP_125_18_3709C13","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/j.1460-2075.1990.tb08270.x","article-title":"Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes","volume":"9","author":"Forrest","year":"1990","journal-title":"EMBO J"},{"key":"2025021501572872900_DEVELOP_125_18_3709C14","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/ng0796-354","article-title":"Thyroid hormone receptor \u03b2 is essential for development of auditory function","volume":"13","author":"Forrest","year":"1996","journal-title":"Nature Genet."},{"key":"2025021501572872900_DEVELOP_125_18_3709C15","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/0003-9861(84)90013-4","article-title":"Triiodothyronine depresses the NAD-linked glycerol-3-phosphate dehydrogenase activity of cultured neonatal rat heart cells","volume":"228","author":"Freerksen","year":"1984","journal-title":"Arch. Biochem. Biophys."},{"key":"2025021501572872900_DEVELOP_125_18_3709C16","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1046\/j.1365-2826.1997.d01-1088.x","article-title":"Differential distribution of thyroid hormone receptor isoform in rat dorsal root ganglia and sciatic nerve in vivo and in vitro","volume":"9","author":"Glauser","year":"1997","journal-title":"J. Neuroendocrin."},{"key":"2025021501572872900_DEVELOP_125_18_3709C17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0959-4388(93)90040-6","article-title":"Activity-dependent structural changes during neuronal development","volume":"3","author":"Hockfield","year":"1993","journal-title":"Curr. Opin. Neurobiol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C18","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1126\/science.2539642","article-title":"Identification of a thyroid hormone receptor that is pituitary-specific","volume":"244","author":"Hodin","year":"1989","journal-title":"Science"},{"key":"2025021501572872900_DEVELOP_125_18_3709C19","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/0378-5955(95)00060-H","article-title":"Immunological identification of candidate proteins involved in regulating active shape changes of outer hair cells","volume":"86","author":"Knipper","year":"1995","journal-title":"Hear Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0165-3806(95)00113-R","article-title":"Synaptophysin and GAP-43 proteins in efferent fibers of the inner ear during postnatal development","volume":"89","author":"Knipper","year":"1995","journal-title":"Dev. Brain Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C21","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s004410050545","article-title":"Expression of neurotrophin receptor trkB in rat cochlear hair cells at time of rearrangement of innervation","volume":"283","author":"Knipper","year":"1996","journal-title":"Cell Tissue Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s004410050729","article-title":"Transient expression of NMDA receptors during rearrangement of AMPA-receptor-expressing fibers in the developing inner ear","volume":"287","author":"Knipper","year":"1997","journal-title":"Cell Tissue Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C23","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1126\/science.7770777","article-title":"Progesterone synthesis and myelin formation by Schwann cells","volume":"268","author":"Koenig","year":"1995","journal-title":"Science"},{"key":"2025021501572872900_DEVELOP_125_18_3709C24","first-page":"1","article-title":"Development of behaviour patterns and myelinization of the nervous system in the human fetus and infant","volume":"24","author":"Langworthy","year":"1933","journal-title":"Contrib. Embryol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1210\/mend-2-6-479","article-title":"Regulation of two c-erbA messenger ribonucleic acids in rat GH3 Cells by thyroid hormone","volume":"2","author":"Lazar","year":"1988","journal-title":"Mol. Endocrin."},{"key":"2025021501572872900_DEVELOP_125_18_3709C26","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1210\/endo.132.6.7684976","article-title":"Immunocytochemical delineation of thyroid hormone receptor \u00df2-like immunoreactivity in the rat central nervous system","volume":"132","author":"Lechan","year":"1993","journal-title":"Endocrinol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4757-1830-0_6","volume-title":"Myelin","author":"Lees","year":"1984"},{"key":"2025021501572872900_DEVELOP_125_18_3709C28","first-page":"279","article-title":"Effect of thyroid hormone on brain development with particular emphasis on glial cells and myelination","volume":"9","year":"1980","journal-title":"Dev. Neurosci."},{"key":"2025021501572872900_DEVELOP_125_18_3709C29","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/0896-6273(88)90103-1","article-title":"Unwrapping the genes of myelin","volume":"1","author":"Lemke","year":"1988","journal-title":"Neuron"},{"key":"2025021501572872900_DEVELOP_125_18_3709C30","first-page":"395","article-title":"Unwrapping myelination [news] Nature,","volume":"383","author":"Lemke","year":"1995"},{"key":"2025021501572872900_DEVELOP_125_18_3709C31","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/0092-8674(85)90198-9","article-title":"Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin","volume":"40","author":"Lemke","year":"1985","journal-title":"Cell"},{"key":"2025021501572872900_DEVELOP_125_18_3709C32","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1210\/endo-128-5-2601","article-title":"Intracellular distribution of the endogenous and transfected \u03b2 form of thyroid hormone nuclear receptor visualized by the use of domain-specific monoclonal antibodies","volume":"128","author":"Lin","year":"1991","journal-title":"Endocrinol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C33","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1210\/endo-126-6-3232","article-title":"Characterization of site-specific polyclonal antibodies to c-erbA peptides recognizing human thyroid hormone receptors \u03b11, \u03b12 and \u03b2 and native 3,5,3\u2032-triiodothyronine receptor, and study of tissue distribution of the antigen","volume":"126","author":"Macchia","year":"1990","journal-title":"Endocrinol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C34","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0092-8674(85)90289-2","article-title":"Nucleotide sequence of two mRNAs for rat brain myelin proteolipid protein","volume":"42","author":"Milner","year":"1985","journal-title":"Cell"},{"key":"2025021501572872900_DEVELOP_125_18_3709C35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0378-5955(95)00073-D","article-title":"Time course of axonal myelination in the human brainstem auditory pathway","volume":"87","author":"Moore","year":"1995","journal-title":"Hear. Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C36","doi-asserted-by":"publisher","first-page":"12770","DOI":"10.1016\/S0021-9258(18)37820-7","article-title":"Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors","volume":"263","author":"Murray","year":"1988","journal-title":"J. Biol. Chem."},{"key":"2025021501572872900_DEVELOP_125_18_3709C37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1471-4159.1982.tb10878.x","article-title":"Postnatal action of growth and thyroid hormones on the retarded cerebral myelinogenesis of Snell dwarf mice (dw","volume":"38","author":"Noguchi","year":"1982","journal-title":"J. Neurochem."},{"key":"2025021501572872900_DEVELOP_125_18_3709C38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1530\/eje.0.1300015","article-title":"Thyroid hormone action 1994: the plot thickens","volume":"130","author":"Oppenheimer","year":"1994","journal-title":"Eur. J. of Endocrinol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3810\/pgm.1997.09.318","article-title":"Endocrinologic causes of peripheral neuropathy","volume":"102","author":"Perkins","year":"1997","journal-title":"Postgrad. Med."},{"key":"2025021501572872900_DEVELOP_125_18_3709C40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0169-328X(95)00189-Y","article-title":"Regulation of actin and tubulin gene expression by thyroid hormone during rat brain development","volume":"35","author":"Poddar","year":"1996","journal-title":"Mol. Brain Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C41","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3109\/00016487209128467","article-title":"Development of tone-burst responses along the auditory pathway in the cat","volume":"74","author":"Pujol","year":"1972","journal-title":"Acta Otolaryngol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/00016487309121476","article-title":"Anatomy and physiology of the onset of auditory function","volume":"76","author":"Pujol","year":"1973","journal-title":"Acta Otolaryngol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C43","first-page":"348","article-title":"The syndromes of resistance to thyroid hormone","volume":"14","author":"Refetoff","year":"1993","journal-title":"Endocrin. Rev."},{"key":"2025021501572872900_DEVELOP_125_18_3709C44","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/0092-8674(83)90536-6","article-title":"Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiver mutant mice","volume":"34","author":"Roach","year":"1983","journal-title":"Cell"},{"key":"2025021501572872900_DEVELOP_125_18_3709C45","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1172\/JCI116301","article-title":"Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain","volume":"91","author":"Rodriguez-Pena","year":"1993","journal-title":"J. Clin. Invest."},{"key":"2025021501572872900_DEVELOP_125_18_3709C46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.901700102","article-title":"The structural maturation of the stato-acoustic nerve in the cat","volume":"170","author":"Romand","year":"1976","journal-title":"J. Comp. Neurol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C47","first-page":"135","volume-title":"Handbook of Sensory Physiology, Vol. IX: Development of Sensory Systems","author":"Rubel","year":"1978"},{"key":"2025021501572872900_DEVELOP_125_18_3709C48","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1111\/j.1460-9568.1995.tb01052.x","article-title":"Inhibition of PC12 cell attachment and neurite outgrowth by detergent solubilized CNS myelin proteins","volume":"7","author":"Rubin","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"2025021501572872900_DEVELOP_125_18_3709C49","first-page":"30","article-title":"Experimental procedure for the detection of rare human mRNA with the DIG system","volume":"99","author":"Rueger","year":"1996","journal-title":"Boehringer Mannheim Information"},{"key":"2025021501572872900_DEVELOP_125_18_3709C50","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/340242a0","article-title":"Repression of transcription mediated at a TH response element","volume":"340","author":"Sap","year":"1986","journal-title":"Nature"},{"key":"2025021501572872900_DEVELOP_125_18_3709C51","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/BF00267823","article-title":"Single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells; in situ hybridization using digoxigenin-labeled cRNA probes","volume":"100","author":"Schaeren-Wiemers","year":"1993","journal-title":"Histochem."},{"key":"2025021501572872900_DEVELOP_125_18_3709C52","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/jnr.490320203","article-title":"Axons modulate the expression of proteolipid protein in the CNS","volume":"32","author":"Scherer","year":"1992","journal-title":"J. Neurosci. Res"},{"key":"2025021501572872900_DEVELOP_125_18_3709C53","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1097\/00019052-199710000-00006","article-title":"The biology and pathobiology of Schwann cells","volume":"10","author":"Scherer","year":"1997","journal-title":"Curr. Opin. Neurol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C54","first-page":"1874","article-title":"\u03b21 Isoform-specific regulation of a triiodothyronine-induced gene during cerebellar development","volume":"6","author":"Strait","year":"1992","journal-title":"Mol. Endocrinol."},{"key":"2025021501572872900_DEVELOP_125_18_3709C55","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/j.1460-9568.1995.tb00345.x","article-title":"Receptor expression in olfactory neurons during rat development: In situ hybridization studies","volume":"7","author":"Strotmann","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"2025021501572872900_DEVELOP_125_18_3709C56","first-page":"49","article-title":"Recessive inheritance of thyroid hormone resistance caused by complete deletion of the protein-coding region of the thyroid hormone receptor \u03b2 gene","volume":"74","author":"Takeda","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2025021501572872900_DEVELOP_125_18_3709C57","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1111\/j.1471-4159.1992.tb11009.x","article-title":"Triiodothyronine has diverse and multiple stimulting effects on expression of the major myelin protein genes","volume":"59","author":"Tosic","year":"1992","journal-title":"J. Neurochem."},{"key":"2025021501572872900_DEVELOP_125_18_3709C58","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0165-3806(83)90186-4","article-title":"Cochlear synaptogenesis in the hypothyroid rat","volume":"7","author":"Uziel","year":"1983","journal-title":"Dev. Brain Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C59","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0378-5955(83)90079-5","article-title":"Maturational and degenerative processes in the organ of Corti after neonatal hypothyroidism","volume":"11","author":"Uziel","year":"1983","journal-title":"Hear. Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C60","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0165-3806(85)90236-6","article-title":"Corrective effects of thyroxine on cochlear abnormalities induced by congenital hypothyroidism in the rat. I. Morphogical study","volume":"19","author":"Uziel","year":"1985","journal-title":"Dev. Brain Res."},{"key":"2025021501572872900_DEVELOP_125_18_3709C61","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/00001756-199311180-00010","article-title":"Nuclear triiodothyronine receptor expression is regulated by axon-Schwann cell contact","volume":"5","author":"Walter","year":"1993","journal-title":"Neuroreport"},{"key":"2025021501572872900_DEVELOP_125_18_3709C62","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1365-2826.1995.tb00675.x","article-title":"Nuclear and cytoplasmic triiodothyronine-binding sites in primary sensory neurons and Schwann cells; radioautographic study during development","author":"Walter","year":"1995","journal-title":"J. Neuroendocrin. 7,"},{"key":"2025021501572872900_DEVELOP_125_18_3709C63","first-page":"1","volume-title":"Handbook of clinical Neurology","author":"Waxman","year":"1985"},{"key":"2025021501572872900_DEVELOP_125_18_3709C64","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/324641a0","article-title":"The c-erbA encodes a thryroid hormone receptor","volume":"324","author":"Weinberger","year":"1986","journal-title":"Nature"},{"key":"2025021501572872900_DEVELOP_125_18_3709C65","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1101\/gad.4.11.1917","article-title":"A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis","volume":"4","author":"Yaoita","year":"1990","journal-title":"Genes Dev."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/18\/3709\/3139744\/develop_125_18_3709.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/18\/3709\/3139744\/develop_125_18_3709.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T20:57:50Z","timestamp":1739566670000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/125\/18\/3709\/39929\/Thyroid-hormone-affects-Schwann-cell-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,15]]},"references-count":65,"journal-issue":{"issue":"18","published-print":{"date-parts":[[1998,9,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.125.18.3709","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,15]]}}}