{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:11:01Z","timestamp":1790395861065,"version":"4.1.0"},"reference-count":50,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>We have identified a new Caenorhabditis elegans NK-2 class homeobox gene, designated ceh-24. Distinct cis-acting elements generate a complex neuronal and mesodermal expression pattern. A promoter-proximal enhancer mediates expression in a single pharyngeal muscle, the donut-shaped m8 cell at the posterior end of the pharynx. A second mesodermal enhancer is active in a set of eight nonstriated vulval muscles used in egg laying. Activation in the egg laying muscles requires an \u2018NdE-box\u2019 consensus motif (CATATG) which is related to, but distinct from, the standard E-box motif bound by the MyoD family of transcriptional activators. Ectodermal expression of ceh-24 is limited to a subset of sublateral motor neurons in the head of the animal; this activity requires a cis-acting activator element that is distinct from the control elements for pharyngeal and vulval muscle expression. Activation of ceh-24 in each of the three cell types coincides with the onset of differentiation. Using a set of transposon-induced null mutations, we show that ceh-24 is not essential for the formation of any of these cells. Although ceh-24 mutants have no evident defects under laboratory conditions, the pattern of ceh-24 activity is apparently important for Rhabditid nematodes: the related species C. briggsae contains a close homologue of C. elegans ceh-24 including a highly conserved and functionally equivalent set of cis-acting control signals.<\/jats:p>","DOI":"10.1242\/dev.125.3.421","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:31:07Z","timestamp":1619407867000},"page":"421-429","source":"Crossref","is-referenced-by-count":77,"title":["Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1242","volume":"125","author":[{"given":"Brian D.","family":"Harfe","sequence":"first","affiliation":[{"name":"115 W. University Parkway 1 Carnegie Institution of Washington, Department of Embryology , , Baltimore, MD 21210, USA"},{"name":"The Johns Hopkins University 2 , Graduate Program in Biology, Baltimore, MD 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fire","sequence":"additional","affiliation":[{"name":"115 W. 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