{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T21:15:26Z","timestamp":1779138926484,"version":"3.51.4"},"reference-count":34,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[1998,3,15]],"date-time":"1998-03-15T00:00:00Z","timestamp":889920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>During the development of the egg-laying system in Caenorhabditis elegans hermaphrodites, central gonadal cells organize the alignment of the vulva with the sex myoblasts, the progenitors of the egg-laying muscles. A fibroblast growth factor [EGL-17(FGF)] and an FGF receptor [EGL-15(FGFR)] are involved in the gonadal signals that guide the migrations of the sex myoblasts. Here we show that EGL-17(FGF) can act as an instructive guidance cue to direct the sex myoblasts to their final destinations. We find that egl-17 reporter constructs are expressed in the primary vulval cell and that EGL-17(FGF) expression in this cell correlates with the precise positioning of the sex myoblasts. We postulate that EGL-17(FGF) helps to coordinate the development of a functional egg-laying system, linking vulval induction with proper sex myoblast migration.<\/jats:p>","DOI":"10.1242\/dev.125.6.1083","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:42:54Z","timestamp":1619206974000},"page":"1083-1093","source":"Crossref","is-referenced-by-count":176,"title":["EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in <i>C. elegans<\/i>"],"prefix":"10.1242","volume":"125","author":[{"given":"Rebecca D.","family":"Burdine","sequence":"first","affiliation":[{"name":"Yale University School of Medicine 1 Department of Cell Biology , , PO Box 208005, New Haven, Connecticut 06520-8005, USA"},{"name":"Yale University School of Medicine 2 Department of Cell Biology and Genetics , , PO Box 208005, New Haven, Connecticut 06520-8005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine S.","family":"Branda","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine 2 Department of Cell Biology and Genetics , , PO Box 208005, New Haven, Connecticut 06520-8005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Stern","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine 2 Department of Cell Biology and Genetics , , PO Box 208005, New Haven, Connecticut 06520-8005, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1998,3,15]]},"reference":[{"key":"2025021500513970700_DEVELOP_125_6_1083C1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/genetics\/128.2.251","article-title":"Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction","volume":"128","author":"Aroian","year":"1991","journal-title":"Genetics"},{"key":"2025021500513970700_DEVELOP_125_6_1083C2","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/0092-8674(87)90593-9","article-title":"A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant","volume":"51","author":"Avery","year":"1987","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C3","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/348503a0","article-title":"Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction","volume":"348","author":"Beitel","year":"1990","journal-title":"Nature"},{"key":"2025021500513970700_DEVELOP_125_6_1083C4","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1073\/pnas.94.6.2433","article-title":"egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans","volume":"94","author":"Burdine","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021500513970700_DEVELOP_125_6_1083C5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1006\/dbio.1996.8473","article-title":"Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in C. elegans hermaphrodites","volume":"182","author":"Chen","year":"1997","journal-title":"Dev. Biol."},{"key":"2025021500513970700_DEVELOP_125_6_1083C6","first-page":"150","volume":"182","author":"Clandinin","year":"1997","journal-title":"Caenorhabditis elegans HOM-C genes regulate the response of vulval precursor cells to inductive signal. Dev. Biol."},{"key":"2025021500513970700_DEVELOP_125_6_1083C7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0092-8674(93)90293-Y","article-title":"Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39","volume":"74","author":"Clark","year":"1993","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C8","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0092-8674(95)90101-9","article-title":"An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites","volume":"83","author":"DeVore","year":"1995","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/326259a0","article-title":"A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans","volume":"326","author":"Ferguson","year":"1987","journal-title":"Nature"},{"key":"2025021500513970700_DEVELOP_125_6_1083C10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0378-1119(90)90224-F","article-title":"A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans","volume":"93","author":"Fire","year":"1990","journal-title":"Gene"},{"key":"2025021500513970700_DEVELOP_125_6_1083C11","author":"Freyd","year":"1991"},{"key":"2025021500513970700_DEVELOP_125_6_1083C12","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1242\/dev.117.3.1071","article-title":"Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans","volume":"117","author":"Garriga","year":"1993","journal-title":"Development"},{"key":"2025021500513970700_DEVELOP_125_6_1083C13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/0092-8674(83)90377-X","article-title":"The lin-12 locus specifies cell fates in Caenorhabditis elegans","volume":"34","author":"Greenwald","year":"1983","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C14","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/358470a0","article-title":"The gene lin-3 encodes an inductive signal for vulval development in C. elegans","volume":"358","author":"Hill","year":"1992","journal-title":"Nature"},{"key":"2025021500513970700_DEVELOP_125_6_1083C15","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1242\/dev.119.Supplement.9","article-title":"Cell fate patterning during C. elegans development","volume":"1993","author":"Hill","year":"1993","journal-title":"Development"},{"key":"2025021500513970700_DEVELOP_125_6_1083C16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/351535a0","article-title":"Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva","volume":"351","author":"Horvitz","year":"1991","journal-title":"Nature"},{"key":"2025021500513970700_DEVELOP_125_6_1083C17","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0092-8674(95)90302-X","article-title":"A perfect vulva every time: gradients and signaling cascades in C. elegans","volume":"82","author":"Kenyon","year":"1995","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C18","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/0012-1606(81)90152-4","article-title":"Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans","volume":"87","author":"Kimble","year":"1981","journal-title":"Dev. Biol."},{"key":"2025021500513970700_DEVELOP_125_6_1083C19","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/0896-6273(90)90195-L","article-title":"Organogenesis in C. elegans: positioning of neurons and muscles in the egg-laying system","volume":"4","author":"Li","year":"1990","journal-title":"Neuron"},{"key":"2025021500513970700_DEVELOP_125_6_1083C20","doi-asserted-by":"publisher","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J."},{"key":"2025021500513970700_DEVELOP_125_6_1083C21","doi-asserted-by":"publisher","first-page":"9329","DOI":"10.1073\/pnas.93.18.9329","article-title":"Coordinated morphogenesis of epithelia during the development of the Caenorhabditis elegans uterine-vulval connection","volume":"93","author":"Newman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025021500513970700_DEVELOP_125_6_1083C22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1242\/dev.124.1.243","article-title":"Evolutionary changes of developmental mechanisms in the absence of cell lineage alterations during vulva formation in the Diplogastridae (Nematoda","volume":"124","author":"Sommer","year":"1997","journal-title":"Development"},{"key":"2025021500513970700_DEVELOP_125_6_1083C23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1242\/dev.113.3.797","article-title":"A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants","volume":"113","author":"Stern","year":"1991","journal-title":"Development"},{"key":"2025021500513970700_DEVELOP_125_6_1083C24","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/0092-8674(86)90842-1","article-title":"Pattern formation during vulval development in C. elegans","volume":"44","author":"Sternberg","year":"1986","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0092-8674(93)90424-O","article-title":"Intrinsic activity of the lin-12 and notch intracellular domains in vivo","volume":"74","author":"Struhl","year":"1993","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C26","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"2025021500513970700_DEVELOP_125_6_1083C27","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0012-1606(80)90353-X","article-title":"Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans","volume":"78","author":"Sulston","year":"1980","journal-title":"Dev. Biol."},{"key":"2025021500513970700_DEVELOP_125_6_1083C28","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/0092-8674(95)90205-8","article-title":"The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction","volume":"83","author":"Sundaram","year":"1995","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C29","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/bies.950180609","article-title":"Control and integration of cell signaling pathways during C. elegans vulval development","volume":"18","author":"Sundaram","year":"1996","journal-title":"BioEssays"},{"key":"2025021500513970700_DEVELOP_125_6_1083C30","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1242\/dev.122.9.2823","article-title":"A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans","volume":"122","author":"Sundaram","year":"1996","journal-title":"Development"},{"key":"2025021500513970700_DEVELOP_125_6_1083C31","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S0092-8674(00)81803-6","article-title":"branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching","volume":"87","author":"Sutherland","year":"1996","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C32","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/0092-8674(90)90382-O","article-title":"Cell interactions coordinate the development of the C. elegans egg-laying system","volume":"62","author":"Thomas","year":"1990","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0092-8674(93)90292-X","article-title":"A homeotic gene cluster patterns the anteroposterior body axis of C. elegans","volume":"74","author":"Wang","year":"1993","journal-title":"Cell"},{"key":"2025021500513970700_DEVELOP_125_6_1083C34","first-page":"81","volume-title":"The Nematode Caenorhabditis elegans","author":"White","year":"1988"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/6\/1083\/3137055\/develop_125_6_1083.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/6\/1083\/3137055\/develop_125_6_1083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:51:53Z","timestamp":1739580713000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/125\/6\/1083\/40169\/EGL-17-FGF-expression-coordinates-the-attraction"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3,15]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,3,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.125.6.1083","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3,15]]}}}