{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:20:23Z","timestamp":1791102023298,"version":"4.1.0"},"reference-count":83,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[1998,3,15]],"date-time":"1998-03-15T00:00:00Z","timestamp":889920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The analysis of Hoxa1 and Hoxb1 null mutants suggested that these genes are involved in distinct aspects of hindbrain segmentation and specification. Here we investigate the possible functional synergy of the two genes. The generation of Hoxa13\u2032RARE\/Hoxb13\u2032RARE compound mutants resulted in mild facial motor nerve defects reminiscent of those present in the Hoxb1 null mutants. Strong genetic interactions between Hoxa1 and Hoxb1 were uncovered by introducing the Hoxb13\u2032RARE and Hoxb1 null mutations into the Hoxa1 null genetic background. Hoxa1null\/Hoxb13\u2032RARE and Hoxa1null\/Hoxb1null double homozygous embryos showed additional patterning defects in the r4-r6 region but maintained a molecularly distinct r4-like territory. Neurofilament staining and retrograde labelling of motor neurons indicated that Hoxa1 and Hoxb1 synergise in patterning the VIIth through XIth cranial nerves. The second arch expression of neural crest cell markers was abolished or dramatically reduced, suggesting a defect in this cell population. Strikingly, the second arch of the double mutant embryos involuted by 10.5 dpc and this resulted in loss of all second arch-derived elements and complete disruption of external and middle ear development. Additional defects, most notably the lack of tympanic ring, were found in first arch-derived elements, suggesting that interactions between first and second arch take place during development. Taken together, our results unveil an extensive functional synergy between Hoxa1 and Hoxb1 that was not anticipated from the phenotypes of the simple null mutants.<\/jats:p>","DOI":"10.1242\/dev.125.6.1123","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:45:11Z","timestamp":1619207111000},"page":"1123-1136","source":"Crossref","is-referenced-by-count":279,"title":["<i>Hoxa1<\/i> and <i>Hoxb1<\/i> synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch"],"prefix":"10.1242","volume":"125","author":[{"given":"Anthony","family":"Gavalas","sequence":"first","affiliation":[{"name":"1 Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire and Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163 -67404 Illkirch Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Studer","sequence":"additional","affiliation":[{"name":"2 Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lumsden","sequence":"additional","affiliation":[{"name":"3 Department of Developmental Neurobiology, UMDS, Guy\u2019s Hospital, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo M.","family":"Rijli","sequence":"additional","affiliation":[{"name":"1 Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire and Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163 -67404 Illkirch Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robb","family":"Krumlauf","sequence":"additional","affiliation":[{"name":"2 Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[{"name":"1 Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire and Cellulaire, CNRS\/INSERM\/ULP, Coll\u00e8ge de France, BP 163 -67404 Illkirch Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1998,3,15]]},"reference":[{"key":"2025021500513866000_DEVELOP_125_6_1123C1","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1242\/dev.122.12.3817","article-title":"Targeted disruption of the Hob-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4","volume":"122","author":"Barrow","year":"1996","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1242\/dev.118.4.1063","article-title":"Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain","volume":"118","author":"Carpenter","year":"1993","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/j.1460-2075.1988.tb02780.x","article-title":"A gene encoding a protein with zinc fingers is activated during G0\/G1 transition in cultured cells","volume":"7","author":"Chavrier","year":"1988","journal-title":"EMBO J."},{"key":"2025021500513866000_DEVELOP_125_6_1123C4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/350473a0","article-title":"Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene Hox-1.5 [see comments]","volume":"350","author":"Chisaka","year":"1991","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C5","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/355516a0","article-title":"Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6 [see comments]","volume":"355","author":"Chisaka","year":"1992","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C6","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1073\/pnas.92.6.2249","article-title":"Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain","volume":"92","author":"Cook\u00e9","year":"1995","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"2025021500513866000_DEVELOP_125_6_1123C7","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0092-8674(94)90033-7","article-title":"The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor","volume":"79","author":"Cordes","year":"1994","journal-title":"Cell"},{"key":"2025021500513866000_DEVELOP_125_6_1123C8","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1242\/dev.117.2.409","article-title":"The triple origin of skull in higher vertebrates: a study in quail-chick chimeras","volume":"117","author":"Couly","year":"1993","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C9","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1242\/dev.121.2.439","article-title":"The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo","volume":"121","author":"Crossley","year":"1995","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C10","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/aja.1001660406","article-title":"Contributions of placodal and neural crest cells to avian cranial peripheral ganglia","volume":"166","author":"D\u2019Amico-Martel","year":"1983","journal-title":"Am. J. Anat."},{"key":"2025021500513866000_DEVELOP_125_6_1123C11","doi-asserted-by":"publisher","first-page":"7666","DOI":"10.1073\/pnas.90.16.7666","article-title":"Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1. 6) mutant embryos","volume":"90","author":"Doll\u00e9","year":"1993","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"2025021500513866000_DEVELOP_125_6_1123C12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0925-4773(93)90073-7","article-title":"Murine FGF-4 gene expression is spatially restricted within embryonic skeletal muscle and other tissues","volume":"40","author":"Drucker","year":"1993","journal-title":"Mech. Dev."},{"key":"2025021500513866000_DEVELOP_125_6_1123C13","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1242\/dev.124.2.399","article-title":"In vivo functional analysis of the Hoxa-1 3\u2032 retinoic acid response element (3\u2032RARE","volume":"124","author":"Dup\u00e9","year":"1997","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C14","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1093\/molehr\/3.2.115","article-title":"Developmental functions of mammalian Hox genes","volume":"3","author":"Favier","year":"1997","journal-title":"Mol. Hum. Reprod."},{"key":"2025021500513866000_DEVELOP_125_6_1123C15","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/344431a0","article-title":"Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions","volume":"344","author":"Fraser","year":"1990","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C16","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1242\/dev.110.2.589","article-title":"Isolation of the mouse Hox-2. 9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm","volume":"110","author":"Frohman","year":"1990","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C17","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1242\/dev.117.3.925","article-title":"Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr","volume":"117","author":"Frohman","year":"1993","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C18","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1242\/dev.122.3.783","article-title":"Late effects of retinoic acid on neural crest and aspects of rhombomere","volume":"122","author":"Gale","year":"1996","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C19","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1242\/dev.117.2.769","article-title":"Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall","volume":"117","author":"Gaunt","year":"1993","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C20","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1242\/dev.124.19.3693","article-title":"Control of axon guidance and rostral hindbrain patterning by Hoxa-2","volume":"124","author":"Gavalas","year":"1997","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C21","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/0092-8674(93)90619-2","article-title":"Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest","volume":"75","author":"Gendron-Maguire","year":"1993","journal-title":"Cell"},{"key":"2025021500513866000_DEVELOP_125_6_1123C22","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1242\/dev.122.10.3217","article-title":"Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve","volume":"122","author":"Goddard","year":"1996","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C23","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/372684a0","article-title":"The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest","volume":"372","author":"Graham","year":"1994","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1242\/dev.119.1.233","article-title":"Even-numbered rhombomeres control the apoptotic elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain","volume":"119","author":"Graham","year":"1993","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1242\/dev.112.1.221","article-title":"Formation and regeneration of rhombomere boundaries in the developing chick hindbrain","volume":"112","author":"Guthrie","year":"1991","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C26","first-page":"527","volume-title":"Selective dispersal of avian rhombomere cells in orthotopic and heterotopic grafts. Development","author":"Guthrie","year":"1993"},{"key":"2025021500513866000_DEVELOP_125_6_1123C27","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0925-4773(94)90022-1","article-title":"Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system","volume":"48","author":"Heikinheimo","year":"1994","journal-title":"Mech. Dev."},{"key":"2025021500513866000_DEVELOP_125_6_1123C28","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/353861a0","article-title":"A distinct Hox code for the branchial region of the vertebrate head","volume":"353","author":"Hunt","year":"1991","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0896-6273(93)90328-O","article-title":"Reversal of axonal pathways from rhombomere 3 correlates with extra Hox expression domains","volume":"10","author":"Kessel","year":"1993","journal-title":"Neuron"},{"key":"2025021500513866000_DEVELOP_125_6_1123C30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1146\/annurev.ne.17.030194.000545","volume":"17","author":"Keynes","year":"1994","journal-title":"Hox genes and regionalization of the nervous system. Annu. Rev. Neurosci."},{"key":"2025021500513866000_DEVELOP_125_6_1123C31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0896-6273(90)90438-L","article-title":"Segmentation and the origin of regional diversity in the vertebrate central nervous system","volume":"4","author":"Keynes","year":"1990","journal-title":"Neuron"},{"key":"2025021500513866000_DEVELOP_125_6_1123C32","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1242\/dev.122.10.3229","article-title":"Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny","volume":"122","author":"K\u00f6ntges","year":"1996","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C33","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/368703a0","article-title":"Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1 [see comments]","volume":"368","author":"Kurihara","year":"1994","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C34","first-page":"3906","article-title":"Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox","volume":"8","author":"La Rosa","year":"1988","journal-title":"Mol. Cell Biol."},{"key":"2025021500513866000_DEVELOP_125_6_1123C35","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S0030-6665(20)30313-3","article-title":"Congenital malformations of the external auditory canal","volume":"29","author":"Lambert","year":"1996","journal-title":"Otolaryngol. Clin. North Am."},{"key":"2025021500513866000_DEVELOP_125_6_1123C36","first-page":"125","article-title":"Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos","volume":"34","author":"Le Lievre","year":"1975","journal-title":"J. Embryol. exp. Morph."},{"key":"2025021500513866000_DEVELOP_125_6_1123C37","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/0092-8674(91)90034-V","article-title":"Disruption of the Hox-1. 6 homeobox gene results in defects in a region corresponding to its rostral domain of expression","volume":"66","author":"Lufkin","year":"1991","journal-title":"Cell"},{"key":"2025021500513866000_DEVELOP_125_6_1123C38","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/337424a0","article-title":"Segmental patterns of neuronal development in the chick hindbrain","volume":"337","author":"Lumsden","year":"1989","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C39","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1126\/science.274.5290.1109","article-title":"Patterning the vertebrate neuraxis","volume":"274","author":"Lumsden","year":"1996","journal-title":"Science"},{"key":"2025021500513866000_DEVELOP_125_6_1123C40","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1242\/dev.113.4.1281","article-title":"Segmental origin and migration of neural crest cells in the hindbrain region of the chick embryo","volume":"113","author":"Lumsden","year":"1991","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C41","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1101\/gad.11.14.1885","article-title":"Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1","volume":"11","author":"Maconochie","year":"1997","journal-title":"Genes Dev."},{"key":"2025021500513866000_DEVELOP_125_6_1123C42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0925-4773(92)90011-8","article-title":"Domains of cellular retinoic acid-binding protein I (CRABP I) expression in the hindbrain and neural crest of the mouse embryo","volume":"37","author":"Maden","year":"1992","journal-title":"Mech. Dev."},{"key":"2025021500513866000_DEVELOP_125_6_1123C43","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1242\/dev.121.5.1399","article-title":"Multiple roles for FGF-3 during cranial neural development in the chicken","volume":"121","author":"Mahmood","year":"1995","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C44","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1242\/dev.121.7.1989","article-title":"The role of Hoxa-3 in mouse thymus and thyroid Development","volume":"121","author":"Manley","year":"1995","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C45","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/387191a0","article-title":"Segmental regulation of Hoxb-3 by kreisler","volume":"387","author":"Manzanares","year":"1997","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C46","first-page":"111","article-title":"Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton","volume":"39","author":"Mark","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"2025021500513866000_DEVELOP_125_6_1123C47","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1242\/dev.119.2.319","article-title":"Two rhombomeres are altered in Hoxa-1 mutant mice","volume":"119","author":"Mark","year":"1993","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C48","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/360737a0","article-title":"Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2\/3 into a 4\/5 identity [see comments]","volume":"360","author":"Marshall","year":"1992","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C49","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1242\/dev.120.8.2199","article-title":"The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres","volume":"120","author":"McKay","year":"1994","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C50","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1101\/gad.5.1.105","article-title":"Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis","volume":"5","author":"Mitchell","year":"1991","journal-title":"Genes Dev."},{"key":"2025021500513866000_DEVELOP_125_6_1123C51","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/cne.902130308","article-title":"Developmental relationships between trigeminal ganglia and trigeminal motoneurons in chick embryos. I. Ganglion development is necessary for motoneuron migration","volume":"213","author":"Moody","year":"1983","journal-title":"J. Comp. Neurol."},{"key":"2025021500513866000_DEVELOP_125_6_1123C52","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1242\/dev.111.1.61","article-title":"Expression of the mouse labial-like homeobox-containing genes, Hox 2. 9 and Hox 1. 6, during segmentation of the hindbrain","volume":"111","author":"Murphy","year":"1991","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C53","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1242\/dev.122.8.2367","article-title":"Late emigrating neural crest cells migrate specifically to the exit points of cranial branchiomotor nerves","volume":"122","author":"Niederlander","year":"1996","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C54","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1242\/dev.114.3.755","article-title":"Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse","volume":"114","author":"Niswander","year":"1992","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C55","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1242\/dev.124.12.2297","article-title":"Cell movements, neuronal organisation and gene expression in hindbrains lacking morphological boundaries","volume":"124","author":"Nittenberg","year":"1997","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C56","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1242\/dev.103.Supplement.121","article-title":"Interactions and fates of avian craniofacial mesenchyme","volume":"103","author":"Noden","year":"1988","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C57","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/0012-1606(83)90318-4","article-title":"The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues","volume":"96","author":"Noden","year":"1983","journal-title":"Dev. Biol."},{"key":"2025021500513866000_DEVELOP_125_6_1123C58","first-page":"15","volume-title":"The Biology of Changes in Otolaryngology","author":"Noden","year":"1992"},{"key":"2025021500513866000_DEVELOP_125_6_1123C59","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1242\/dev.122.2.543","article-title":"Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20","volume":"122","author":"Nonchev","year":"1996","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C60","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/S0092-8674(05)80008-X","article-title":"Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent on exd\/pbx","volume":"81","author":"P\u00f6pperl","year":"1995","journal-title":"Cell"},{"key":"2025021500513866000_DEVELOP_125_6_1123C61","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/0092-8674(93)90620-6","article-title":"A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene","volume":"75","author":"Rijli","year":"1993","journal-title":"Cell"},{"key":"2025021500513866000_DEVELOP_125_6_1123C62","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0959-437X(97)80074-3","article-title":"Genetic interactions of Hox genes in limb development: learning from compound mutants","volume":"7","author":"Rijli","year":"1997","journal-title":"Curr. Opin. Genet. Dev. Biol."},{"key":"2025021500513866000_DEVELOP_125_6_1123C63","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1242\/dev.121.9.3005","article-title":"Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development","volume":"121","author":"Rivera-Perez","year":"1995","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C64","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1242\/dev.115.4.973","article-title":"Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis","volume":"115","author":"Ruberte","year":"1992","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C65","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1242\/dev.124.6.1215","article-title":"Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants","volume":"124","author":"Schneider-Maunoury","year":"1997","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C66","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(93)90329-O","article-title":"Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain","volume":"75","author":"Schneider-Maunoury","year":"1993","journal-title":"Cell"},{"key":"2025021500513866000_DEVELOP_125_6_1123C67","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/381235a0","article-title":"Transcription factor AP-2 essential for cranial closure and craniofacial development","volume":"381","author":"Sch\u00f6rle","year":"1996","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C68","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1242\/dev.118.3.691","article-title":"Segmental migration of the hindbrain neural crest does not arise from its segmental generation","volume":"118","author":"Sechrist","year":"1993","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C69","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0925-4773(97)00051-8","article-title":"Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain","volume":"65","author":"Seitanidou","year":"1997","journal-title":"Mech. Dev."},{"key":"2025021500513866000_DEVELOP_125_6_1123C70","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0092-8674(93)90659-E","article-title":"The zinc finger gene Krox20 regulates HoxB2 (Hox2. 8) during hindbrain segmentation","volume":"72","author":"Sham","year":"1993","journal-title":"Cell"},{"key":"2025021500513866000_DEVELOP_125_6_1123C71","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/384630a0","article-title":"Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1","volume":"384","author":"Studer","year":"1996","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C72","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1242\/dev.125.6.1025","article-title":"Genetic interactions between Hoxa1 and Hoxb1 reveal additional roles in regulation of early hindbrain patterning","volume":"125","author":"Studer","year":"1998","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C73","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1101\/gad.7.11.2071","article-title":"Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20","volume":"7","author":"Swiatek","year":"1993","journal-title":"Genes Dev."},{"key":"2025021500513866000_DEVELOP_125_6_1123C74","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1006\/dbio.1996.0173","article-title":"The expression pattern of the mouse receptor tyrosine kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos","volume":"177","author":"Taneja","year":"1996","journal-title":"Dev. Biol."},{"key":"2025021500513866000_DEVELOP_125_6_1123C75","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1242\/dev.121.8.2569","article-title":"Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches","volume":"121","author":"Trainor","year":"1995","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C76","first-page":"5383","volume":"15","author":"Vesque","year":"1996","journal-title":"Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site. EMBO J."},{"key":"2025021500513866000_DEVELOP_125_6_1123C77","first-page":"29","article-title":"Genetic control of segmentation in the vertebrate hindbrain","volume":"3","author":"Wilkinson","year":"1995","journal-title":"Perspect. Dev. Neurobiol."},{"key":"2025021500513866000_DEVELOP_125_6_1123C78","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/337461a0","article-title":"Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse","volume":"337","author":"Wilkinson","year":"1989","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C79","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/341405a0","article-title":"Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain","volume":"341","author":"Wilkinson","year":"1989","journal-title":"Nature"},{"key":"2025021500513866000_DEVELOP_125_6_1123C80","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1002\/j.1460-2075.1988.tb02864.x","article-title":"Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse","volume":"7","author":"Wilkinson","year":"1988","journal-title":"EMBO J."},{"key":"2025021500513866000_DEVELOP_125_6_1123C81","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1242\/dev.122.7.2143","article-title":"Persistence of rhombomeric organisation in the postsegmental hindbrain","volume":"122","author":"Wingate","year":"1996","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C82","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1242\/dev.121.9.2917","article-title":"Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death","volume":"121","author":"Yamada","year":"1995","journal-title":"Development"},{"key":"2025021500513866000_DEVELOP_125_6_1123C83","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/381238a0","article-title":"Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2","volume":"381","author":"Zhang","year":"1996","journal-title":"Nature"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/6\/1123\/3137210\/develop_125_6_1123.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/125\/6\/1123\/3137210\/develop_125_6_1123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:52:14Z","timestamp":1739580734000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/125\/6\/1123\/40177\/Hoxa1-and-Hoxb1-synergize-in-patterning-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3,15]]},"references-count":83,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,3,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.125.6.1123","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3,15]]}}}