{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:43:14Z","timestamp":1791074594088,"version":"4.1.0"},"reference-count":52,"publisher":"The Company of Biologists","issue":"7","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>From egg through adult, C. elegans has six life stages including an option for dauer formation and diapause at larval stage L3 in adverse environments. Somatic cells throughout the organism make consistent choices and advance in unison, suggesting a mechanism of coordinate regulation at these stage transitions. Earlier studies showed that daf-12, which encodes a nuclear receptor (W. Yeh, 1991, Doctoral Thesis. University of Missouri-Columbia), regulates dauer formation; epistasis experiments placed daf-12 near the end of the dauer signaling pathway. Here we describe novel daf-12 alleles that reveal a general role in advancing L3 stage programs. In these mutants, somatic cells repeat L2-specific cellular programs of division and migration at the L3 stage; epistasis experiments place daf-12 between lin-14 and lin-28 within the heterochronic pathway. We propose daf-12 and other heterochronic genes provide cellular memories of chronological stage for selecting stage-appropriate developmental programs. Endocrine factors could coordinate these stage transitions and specify developmental alternatives.<\/jats:p>","DOI":"10.1242\/dev.125.7.1191","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:35:13Z","timestamp":1619408113000},"page":"1191-1205","source":"Crossref","is-referenced-by-count":217,"title":["<i>daf-12<\/i> regulates developmental age and the dauer alternative in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1242","volume":"125","author":[{"given":"Adam","family":"Antebi","sequence":"first","affiliation":[{"name":"Johns Hopkins University 1 Department of Biology , , Baltimore, Maryland 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Culotti","sequence":"additional","affiliation":[{"name":"Samuel Lunenfeld Research Institute 2 Division of Molecular Immunology and Neurobiology , , Mount Sinai Hospital, Toronto M5G 1X5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward M.","family":"Hedgecock","sequence":"additional","affiliation":[{"name":"Johns Hopkins University 1 Department of Biology , , Baltimore, Maryland 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"2025021500580433600_DEVELOP_125_7_1191C1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0092-8674(89)90171-2","article-title":"A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans","volume":"57","author":"Ambros","year":"1989","journal-title":"Cell"},{"key":"2025021500580433600_DEVELOP_125_7_1191C2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1126\/science.6494891","article-title":"Heterochronic mutants of the nematode C. elegans","volume":"226","author":"Ambros","year":"1984","journal-title":"Science"},{"key":"2025021500580433600_DEVELOP_125_7_1191C3","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1101\/gad.1.4.398","article-title":"The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific post-embryonic developmental events","volume":"1","author":"Ambros","year":"1987","journal-title":"Genes Dev."},{"key":"2025021500580433600_DEVELOP_125_7_1191C4","volume-title":"In C. elegans II","author":"Ambros","year":"1997"},{"key":"2025021500580433600_DEVELOP_125_7_1191C5","author":"Antebi","year":"1997"},{"key":"2025021500580433600_DEVELOP_125_7_1191C6","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1101\/gad.5.10.1825","article-title":"Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes lin-4 and lin-28","volume":"5","author":"Arasu","year":"1991","journal-title":"Genes Dev."},{"key":"2025021500580433600_DEVELOP_125_7_1191C7","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/0092-8674(87)90128-0","article-title":"glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans","volume":"51","author":"Austin","year":"1987","journal-title":"Cell"},{"key":"2025021500580433600_DEVELOP_125_7_1191C8","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1242\/dev.122.8.2517","article-title":"Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development","volume":"122","author":"Bettinger","year":"1996","journal-title":"Development"},{"key":"2025021500580433600_DEVELOP_125_7_1191C9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0012-1606(75)90109-8","article-title":"The Dauer-Larva: A Post-Embryonic Developmental Variant of the Nematode C. elegans","volume":"46","author":"Cassada","year":"1975","journal-title":"Dev. 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