{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:29:34Z","timestamp":1787984974579,"version":"build-2784847793"},"reference-count":44,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>In screens for mutants defective in vulval morphogenesis, multiple mutants were isolated in which the uterus and the vulva fail to make a proper connection. We describe five alleles that define the gene cog-2, forconnection of gonad defective. To form a functional connection between the vulva and the uterus, the anchor cell must fuse with the multinucleate uterine seam cell, derived from uterine cells that adopt a \u03c0 lineage. In cog-2mutants, the anchor cell does not fuse to the uterine seam cell and, instead, remains at the apex of the vulva, blocking the connection between the vulval and uterine lumens, resulting in an egg-laying defective phenotype. According to lineage analysis and expression assays for two \u03c0-cell-specific markers, induction of the \u03c0fate occurs normally in cog-2mutants. We have cloned cog-2and shown that it encodes a Sox family transcription factor that is expressed in the \u03c0 lineage. Thus, it appears that COG-2 is a transcription factor that regulates a late-stage aspect of uterine seam cell differentiation that specifically affects anchor cell-uterine seam cell fusion.<\/jats:p>","DOI":"10.1242\/dev.126.1.169","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:27:11Z","timestamp":1619206031000},"page":"169-179","source":"Crossref","is-referenced-by-count":68,"title":["COG-2, a Sox domain protein necessary for establishing a functional vulval- uterine connection in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1242","volume":"126","author":[{"given":"Wendy","family":"Hanna-Rose","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"2023051000262069900_DEVELOP_126_1_169C1","doi-asserted-by":"publisher","first-page":"6321","DOI":"10.1128\/MCB.17.11.6321","article-title":"Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites","volume":"17","author":"Ambrosetti","year":"1997","journal-title":"Mol. 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