{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:31:15Z","timestamp":1791322275883,"version":"4.3.1"},"reference-count":51,"publisher":"The Company of Biologists","issue":"17","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,9,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>Polycomb group (PcG) proteins repress homeotic genes in cells where these genes must remain inactive during development. This repression requires cis-acting silencers, also called PcG response elements. Currently, these silencers are ill-defined sequences and it is not known how PcG proteins associate with DNA. Here, we show that the Drosophila PcG protein Pleiohomeotic binds to specific sites in a silencer of the homeotic gene Ultrabithorax. In an Ultrabithorax reporter gene, point mutations in these Pleiohomeotic binding sites abolish PcG repression in vivo. Hence, DNA-bound Pleiohomeotic protein may function in the recruitment of other non-DNA-binding PcG proteins to homeotic gene silencers.<\/jats:p>","DOI":"10.1242\/dev.126.17.3905","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:47:56Z","timestamp":1619408876000},"page":"3905-3913","source":"Crossref","is-referenced-by-count":167,"title":["The DNA-binding Polycomb group protein Pleiohomeotic mediates silencing of a <i>Drosophila<\/i> homeotic gene"],"prefix":"10.1242","volume":"126","author":[{"given":"Cornelia","family":"Fritsch","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35\/III, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lesley Brown","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda 2 , Maryland 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Kassis","sequence":"additional","affiliation":[{"name":"Laboratory of Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda 2 , Maryland 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie 1 , Spemannstrasse 35\/III, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"2024071014353228500_C1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/313545a0","article-title":"Segmental distribution of bithorax complex proteins during Drosophila development","volume":"313","author":"Beachy","year":"1985","journal-title":"Nature"},{"key":"2024071014353228500_C2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/bies.950170907","article-title":"Transcriptional silencing of homeotic genes in Drosophila","volume":"17","author":"Bienz","year":"1995","journal-title":"BioEssays"},{"key":"2024071014353228500_C3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0092-8674(88)90573-9","article-title":"Differential regulation of Ultrabithorax in two germ layers of Drosophila","volume":"53","author":"Bienz","year":"1988","journal-title":"Cell"},{"key":"2024071014353228500_C4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0012-1606(86)90015-1","article-title":"Maternal expression of genes that regulate the Bithorax complex of Drosophila melanogaster","volume":"118","author":"Breen","year":"1986","journal-title":"Dev. 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