{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:21:40Z","timestamp":1790965300035,"version":"4.1.0"},"reference-count":41,"publisher":"The Company of Biologists","issue":"23","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Caenorhabditis elegans hermaphrodite egg-laying system comprises several tissues, including the uterus and vulva. lin-11 encodes a LIM domain transcription factor needed for certain vulval precursor cells to divide asymmetrically. Based on lin-11 expression studies and the lin-11 mutant phenotype, we find that lin-11 is also required for C. elegans uterine morphogenesis. Specifically, lin-11 is expressed in the ventral uterine intermediate precursor \u03c0 cells and their progeny (the utse and uv1 cells), which connect the uterus to the vulva. Like \u03c0 cell induction, the uterine lin-11 expression responds to the uterine anchor cell and the lin-12-encoded receptor. In wild type animals, the utse, which forms the planar process at the uterine-vulval interface, fuses with the anchor cell. We found that, in lin-11 mutants, utse differentiation was abnormal, the utse failed to fuse with the anchor cell and a functional uterine-vulval connection was not made. These findings indicate that lin-11 is essential for uterine-vulval morphogenesis.<\/jats:p>","DOI":"10.1242\/dev.126.23.5319","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:54:48Z","timestamp":1619409288000},"page":"5319-5326","source":"Crossref","is-referenced-by-count":46,"title":["The <i>lin-11<\/i> LIM domain transcription factor is necessary for morphogenesis of <i>C. elegans<\/i> uterine cells"],"prefix":"10.1242","volume":"126","author":[{"given":"Anna P.","family":"Newman","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute 1 , Division of Biology 156-29 , , Pasadena, CA 91125, USA"},{"name":"California Institute of Technology 1 , Division of Biology 156-29 , , Pasadena, CA 91125, USA"},{"name":"Verna and Marrs McLean Department of Biochemistry 3 , Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3498, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen Z.","family":"Acton","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute 2 , Department of Biology , Room 68-425 , , Cambridge, MA 02139, USA"},{"name":"Massachusetts Institute of Technology 2 , Department of Biology , Room 68-425 , , Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Hartwieg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute 2 , Department of Biology , Room 68-425 , , Cambridge, MA 02139, USA"},{"name":"Massachusetts Institute of Technology 2 , Department of Biology , Room 68-425 , , Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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