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A kin-8 deletion mutant was isolated and showed constitutive dauer larva formation (Daf-c) phenotype: about half of the F1 progeny became dauer larvae when they were cultivated on an old lawn of E. coli as food. Among the cells expressing kin-8::gfp, only ASI sensory neurons are known to express DAF-7 TGF-\u03b2, a key molecule preventing dauer larva formation. In the kin-8 deletion mutant, expression of daf-7::gfp in ASI was greatly reduced, dye-filling in ASI was specifically lost and ASI sensory processes did not completely extend into the amphid pore. The Daf-c phenotype was suppressed by daf- 7 cDNA expression or a daf-3 null mutation. ASI-directed expression of kin-8 cDNA under the daf-7 promoter or expression by a heat shock promoter rescued the dye-filling defect, but not the Daf-c phenotype, of the kin-8 mutant. These results show that the kin-8 mutation causes the Daf- c phenotype through reduction of the daf-7 gene expression and that KIN-8 function is cell-autonomous for the dye- filling in ASI. KIN-8 is required for the process development of ASI, and also involved in promotion of daf- 7 expression through a physiological or developmental function.<\/jats:p>","DOI":"10.1242\/dev.126.23.5387","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:55:45Z","timestamp":1619409345000},"page":"5387-5398","source":"Crossref","is-referenced-by-count":47,"title":["Control of DAF-7 TGF-\u03b2 expression and neuronal process development by a receptor tyrosine kinase KIN-8 in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1242","volume":"126","author":[{"given":"Makoto","family":"Koga","sequence":"first","affiliation":[{"name":"Graduate School of Sciences, Kyushu University Department of Biology , , Fukuoka 812-8581, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Take-uchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuji","family":"Tameishi","sequence":"additional","affiliation":[{"name":"Graduate School of Sciences, Kyushu University Department of Biology , , Fukuoka 812-8581, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1999,12,1]]},"reference":[{"key":"2023090608055307800_DEVELOP_126_23_5387C1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/cne.901980305","article-title":"Sensory control of dauer larva formation in Caenorhabditis elegans","volume":"198","author":"Albert","year":"1981","journal-title":"J. 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