{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:31:03Z","timestamp":1790937063138,"version":"4.1.0"},"reference-count":42,"publisher":"The Company of Biologists","issue":"9","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In Caenorhabditis elegans, the fates of the six multipotent vulva precursor cells (VPCs) are specified by extracellular signals. One VPC expresses the primary (1\u00b0) fate in response to a Ras-mediated inductive signal from the gonad. The two VPCs flanking the 1\u00b0 cell each express secondary (2\u00b0) fates in response to lin-12-mediated lateral signaling. The remaining three VPCs each adopt the non-vulval tertiary (3\u00b0) fate. Here I describe experiments examining how the selection of these vulval fates is affected by cell cycle arrest and cell cycle-restricted lin-12 activity. The results suggest that lin-12 participates in two developmental decisions separable by cell cycle phase: lin-12 must act prior to the end of VPC S phase to influence a 1\u00b0 versus 2\u00b0 cell fate choice, but must act after VPC S phase to influence a 3\u00b0 versus 2\u00b0 cell fate choice. Coupling developmental decisions to cell cycle transitions may provide a mechanism for prioritizing or ordering choices of cell fates for multipotential cells.<\/jats:p>","DOI":"10.1242\/dev.126.9.1947","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T04:03:16Z","timestamp":1619409796000},"page":"1947-1956","source":"Crossref","is-referenced-by-count":87,"title":["Cell cycle-dependent sequencing of cell fate decisions in <i>Caenorhabditis elegans<\/i> vulva precursor cells"],"prefix":"10.1242","volume":"126","author":[{"given":"Victor","family":"Ambros","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"2023090605554896100_DEVELOP_126_9_1947C1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1126\/science.6494891","article-title":"Heterochronic mutants of the nematode Caenorhabditis elegans","volume":"226","author":"Ambros","year":"1984","journal-title":"Science"},{"key":"2023090605554896100_DEVELOP_126_9_1947C2","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1101\/gad.9.24.3149","article-title":"The Caenorhabditis elegans gene LIN-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway","volume":"9","author":"Beitel","year":"1995","journal-title":"Genes Dev"},{"key":"2023090605554896100_DEVELOP_126_9_1947C3","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1242\/dev.122.8.2517","article-title":"Stage-specific accumulation of the terminal differentiation factor LIN-29 during C. 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