{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:22:19Z","timestamp":1790493739781,"version":"4.1.0"},"reference-count":54,"publisher":"The Company of Biologists","issue":"15","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>An essential aspect of a neuron\u2019s identity is the pattern of its axonal projections. In C. elegans, axons extend either longitudinally or circumferentially in response to distinct molecular cues, some of which have been identified. It is currently unclear, however, how the differential capacity to respond to these cues is transcriptionally implemented in distinct neuronal subtypes. Here, we characterise a C. elegans paired-like homeobox gene, CePhox2\/ceh-17, expressed in five head neurons, ALA and the 4 SIAs, all of which project axons towards the tail along the lateral and sublateral cords. Abrogation of ceh-17 function, while leaving intact many phenotypic traits of these neurons, disrupts their antero-posterior axonal elongation beyond the mid-body region. Conversely, ectopic expression of ceh-17 in the mechanoreceptors, several of which are known to pioneer their tract, leads to exaggerated longitudinal axonal outgrowth. Thus, ceh-17 is a novel gene involved in fasciculation-independent longitudinal axonal navigation.<\/jats:p>","DOI":"10.1242\/dev.127.15.3361","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T04:13:00Z","timestamp":1619410380000},"page":"3361-3371","source":"Crossref","is-referenced-by-count":59,"title":["The homeodomain protein CePHOX2\/CEH-17 controls antero-posterior axonal growth in <i>C. elegans<\/i>"],"prefix":"10.1242","volume":"127","author":[{"given":"Nathalie","family":"Pujol","sequence":"first","affiliation":[{"name":"1 Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, Developmental Biology Institute of Marseille, CNRS\/INSERM\/Universit\u00e9 de la M\u00e9diterran\u00e9e\/AP de Marseille, Luminy Case 907, 13288 Marseille Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Torregrossa","sequence":"additional","affiliation":[{"name":"1 Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, Developmental Biology Institute of Marseille, CNRS\/INSERM\/Universit\u00e9 de la M\u00e9diterran\u00e9e\/AP de Marseille, Luminy Case 907, 13288 Marseille Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Ewbank","sequence":"additional","affiliation":[{"name":"2 Centre d\u2019Immunologie de Marseille-Luminy, CNRS\/INSERM, Luminy Case 906, 13288 Marseille Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Brunet","sequence":"additional","affiliation":[{"name":"1 Laboratoire de G\u00e9n\u00e9tique et Physiologie du D\u00e9veloppement, Developmental Biology Institute of Marseille, CNRS\/INSERM\/Universit\u00e9 de la M\u00e9diterran\u00e9e\/AP de Marseille, Luminy Case 907, 13288 Marseille Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2023122523534878900_DEVELOP_127_15_3361C1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1126\/science.8342028","article-title":"The Caenorhabditis elegans unc-17 gene, a putative vesicular acetylcholine transporter","volume":"261","author":"Alfonso","year":"1993","journal-title":"Science"},{"key":"2023122523534878900_DEVELOP_127_15_3361C2","first-page":"583","article-title":"Cell and growth cone migrations","volume-title":"C. elegans II","author":"Antebi","year":"1997"},{"key":"2023122523534878900_DEVELOP_127_15_3361C3","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1242\/dev.126.10.2241","article-title":"The C. elegans homeodomain gene unc-42 regulates chemosensory and glutamate receptor expression","volume":"126","author":"Baran","year":"1999","journal-title":"Development"},{"key":"2023122523534878900_DEVELOP_127_15_3361C4","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1101\/gad.13.4.472","article-title":"The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron","volume":"13","author":"Baum","year":"1999","journal-title":"Genes Dev."},{"key":"2023122523534878900_DEVELOP_127_15_3361C5","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.1073\/pnas.94.7.3414","article-title":"The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation","volume":"94","author":"Bloom","year":"1997","journal-title":"Proc. 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