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In addition, cye-1 is required maternally, but not zygotically for embryonic development. Our analysis of vulval development in cye-1 mutants suggests that a timing mechanism may control the onset of vulval cell terminal differentiation: once induced, these cells appear to differentiate after a set amount of time, rather than a specific number of division cycles. cye-1 mutants also show an increase in the percentage of vulval precursor cells (VPCs) that adopt vulval cell fates, indicating that cell-cycle length can play a role in the proper patterning of vulval cells. By analyzing cul-1 mutants, we further demonstrate that vulval cell terminal differentiation can be uncoupled from associated changes in vulval cell division planes.<\/jats:p>","DOI":"10.1242\/dev.127.18.4049","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T19:57:27Z","timestamp":1619207847000},"page":"4049-4060","source":"Crossref","is-referenced-by-count":74,"title":["Mutations in <i>cye-1<\/i>, a <i>Caenorhabditis elegans<\/i> cyclin E homolog, reveal coordination between cell-cycle control and vulval development"],"prefix":"10.1242","volume":"127","author":[{"given":"David S.","family":"Fay","sequence":"first","affiliation":[{"name":"University of Colorado Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology , , Boulder CO 80309-0347, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Han","sequence":"additional","affiliation":[{"name":"University of Colorado Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology , , Boulder CO 80309-0347, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2000,9,15]]},"reference":[{"key":"2023051123254485600_DEVELOP_127_18_4049C1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0012-1606(78)90122-7","article-title":"Cell Cycling and DNA Replication in a Mutant Blocked in Cell Division in the Nematode Caenorhabditis elegans","volume":"63","author":"Albertson","year":"1978","journal-title":"Dev. 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