{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:44:45Z","timestamp":1774518285141,"version":"3.50.1"},"reference-count":73,"publisher":"The Company of Biologists","issue":"23","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Graded expression of the Eph receptor EphA3 in the retina and its two ligands, ephrin A2 and ephrin A5 in the optic tectum, the primary target of retinal axons, have been implicated in the formation of the retinotectal projection map. Two homeobox containing genes, SOHo1 and GH6, are expressed in a nasal-high, temporal-low pattern during early retinal development, and thus in opposing gradients to EphA3. Retroviral misexpression of SOHo1 or GH6 completely and specifically repressed EphA3 expression in the neural retina, but not in other parts of the central nervous system, such as the optic tectum. Under these conditions, some temporal ganglion cell axons overshot their expected termination zones in the rostral optic tectum, terminating aberrantly at more posterior locations. However, the majority of ganglion cell axons mapped to the appropriate rostrocaudal locations, although they formed somewhat more diffuse termination zones. These findings indicate that other mechanisms, in addition to differential EphA3 expression in the neural retina, are required for retinal ganglion axons to map to the appropriate rostrocaudal locations in the optic tectum. They further suggest that the control of topographic specificity along the retinal nasal-temporal axis is split into several independent pathways already at a very early time in development.<\/jats:p>","DOI":"10.1242\/dev.127.23.5033","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T04:24:42Z","timestamp":1619411082000},"page":"5033-5045","source":"Crossref","is-referenced-by-count":63,"title":["Two homeobox genes define the domain of <i>EphA3<\/i> expression in the developing chick retina"],"prefix":"10.1242","volume":"127","author":[{"given":"Dorothea","family":"Schulte","sequence":"first","affiliation":[{"name":"Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance L.","family":"Cepko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2023030307470752600_","doi-asserted-by":"publisher","first-page":"3637","DOI":"10.1242\/dev.121.11.3637","article-title":"Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch","volume":"121","author":"Austin","year":"1995","journal-title":"Development"},{"key":"2023030307470752600_","volume-title":"Current Protocols in Molecular Biology","author":"Ausubel","year":"1998"},{"key":"2023030307470752600_","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1006\/dbio.1994.1086","article-title":"A novel Nk-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development","volume":"162","author":"Bober","year":"1994","journal-title":"Dev. 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