{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:37:07Z","timestamp":1791268627452,"version":"4.1.0"},"reference-count":94,"publisher":"The Company of Biologists","issue":"23","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The vertebrate brain develops from a bilaterally symmetric neural tube but later displays profound anatomical and functional asymmetries. Despite considerable progress in deciphering mechanisms of visceral organ laterality, the genetic pathways regulating brain asymmetries are unknown. In zebrafish, genes implicated in laterality of the viscera (cyclops\/nodal, antivin\/lefty and pitx2) are coexpressed on the left side of the embryonic dorsal diencephalon, within a region corresponding to the presumptive epiphysis or pineal organ. Asymmetric gene expression in the brain requires an intact midline and Nodal-related factors. RNA-mediated rescue of mutants defective in Nodal signaling corrects tissue patterning at gastrulation, but fails to restore left-sided gene expression in the diencephalon. Such embryos develop into viable adults with seemingly normal brain morphology. However, the pineal organ, which typically emanates at a left-to-medial site from the dorsal diencephalic roof, becomes displaced in position. Thus, a conserved signaling pathway regulating visceral laterality also underlies an anatomical asymmetry of the zebrafish forebrain.<\/jats:p>","DOI":"10.1242\/dev.127.23.5101","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T04:24:54Z","timestamp":1619411094000},"page":"5101-5112","source":"Crossref","is-referenced-by-count":144,"title":["Asymmetric Nodal signaling in the zebrafish diencephalon positions the pineal organ"],"prefix":"10.1242","volume":"127","author":[{"given":"Jennifer O.","family":"Liang","sequence":"first","affiliation":[{"name":"1 Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alton","family":"Etheridge","sequence":"additional","affiliation":[{"name":"2 Department of Biology, The Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Hantsoo","sequence":"additional","affiliation":[{"name":"2 Department of Biology, The Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"1 Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Nowak","sequence":"additional","affiliation":[{"name":"2 Department of Biology, The Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Izpis\u00faa Belmonte","sequence":"additional","affiliation":[{"name":"3 The Salk Institute for Biological Sciences, Gene Expression Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037-1099, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1006\/dbio.1999.9441","article-title":"casanova plays an early and essential role in endoderm formation in zebrafish","volume":"215","author":"Alexander","year":"1999","journal-title":"Dev. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1242\/dev.126.14.3253","article-title":"Regulation of midline development by antagonism of lefty and nodal signaling","volume":"126","author":"Bisgrove","year":"1999","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1242\/dev.127.16.3567","article-title":"Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry","volume":"127","author":"Bisgrove","year":"2000","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/(SICI)1097-0177(199604)205:4&lt;471::AID-AJA10&gt;3.0.CO;2-4","article-title":"Cell proliferation in mammalian gastrulation: the ventral node and notochord are relatively quiescent","volume":"205","author":"Bellomo","year":"1996","journal-title":"Dev. Dyn"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1463-6395.1983.tb00802.x","article-title":"The parapineal organ of teleosts","volume":"64","author":"Borg","year":"1983","journal-title":"Acta Zoologica"},{"key":"2023030307470782300_","first-page":"117","volume-title":"Organization of the Diencephalon and Pretectum of the Ray-finned Fishes","author":"Bradford","year":"1983"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/cne.901380203","article-title":"Exceptions to bilateral symmetry in the epithalamus of lower vertebrates","volume":"138","author":"Braitenberg","year":"1970","journal-title":"J. Comp. Neurol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0006-8993(95)01365-2","article-title":"Circadian regulation of melatonin production in cultured zebrafish pineal and retina","volume":"708","author":"Cahill","year":"1996","journal-title":"Brain Res"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1242\/dev.126.6.1225","article-title":"The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping","volume":"126","author":"Campione","year":"1999","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0092-8674(00)80619-4","article-title":"Mechanisms of left-right determination in vertebrates","volume":"101","author":"Capdevila","year":"2000","journal-title":"Cell"},{"key":"2023030307470782300_","volume-title":"Neuronal Man: The Biology of Mind","author":"Changeux","year":"1985"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1242\/dev.123.1.293","article-title":"Mutations affecting the cardiovascular system and other internal organs in zebrafish","volume":"123","author":"Chen","year":"1996","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1242\/dev.124.21.4373","article-title":"Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish","volume":"124","author":"Chen","year":"1997","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1242\/dev.127.5.1049","article-title":"The lefty-related factor Xatv acts as a feedback inhibitor of Nodal signaling in mesoderm induction and L-R axis development in Xenopus","volume":"127","author":"Cheng","year":"2000","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/381155a0","article-title":"Relationship between asymmetric nodal expression and the direction of embryonic turning","volume":"381","author":"Collignon","year":"1996","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1006\/dbio.1996.0148","article-title":"Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus","volume":"177","author":"Danos","year":"1996","journal-title":"Dev. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"crossref","DOI":"10.1525\/9780520326323","volume-title":"The Third Eye","author":"Eakin","year":"1973"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/BF00318807","article-title":"Transient serotonin-immunoreactive neurons coincide with a critical period of neural development in coho salmon (Oncorhynchus kisutch)","volume":"268","author":"Ebbesson","year":"1992","journal-title":"Cell Tissue Res"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1006\/dbio.1998.9097","article-title":"Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer","volume":"204","author":"Erter","year":"1998","journal-title":"Dev. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1242\/dev.127.5.1081","article-title":"Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms","volume":"127","author":"Essner","year":"2000","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/26013","article-title":"Zebrafish organizer development and germ-layer formation require nodal-related signals","volume":"395","author":"Feldman","year":"1998","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1242\/dev.124.11.2099","article-title":"Fashioning the vertebrate heart: earliest embryonic decisions","volume":"124","author":"Fishman","year":"1997","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1093\/genetics\/144.4.1735","article-title":"Identification of selected gamma-ray induced deficiencies in zebrafish using multiplex polymerase chain reaction","volume":"144","author":"Fritz","year":"1996","journal-title":"Genetics"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1242\/dev.126.20.4643","article-title":"Dosage requirement of Pitx2 for development of multiple organs","volume":"126","author":"Gage","year":"1999","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0960-9822(00)80059-7","article-title":"A role for the cryptic gene in the correct establishment of the left-right axis","volume":"9","author":"Gaio","year":"1999","journal-title":"Curr. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1126\/science.341314","article-title":"Right-left asymmetries in the brain","volume":"199","author":"Galaburda","year":"1978","journal-title":"Science"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1126\/science.161.3837.186","article-title":"Human brain: left-right asymmetries in temporal speech region","volume":"161","author":"Geschwind","year":"1968","journal-title":"Science"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"4895","DOI":"10.1210\/endo.140.10.6975","article-title":"Zebrafish serotonin N-acetyltransferase-2: marker for development of pineal photoreceptors and circadian clock function","volume":"140","author":"Gothilf","year":"1999","journal-title":"Endocrinology"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0092-8674(00)80720-5","article-title":"The EGF-CFC protein One-eyed pinhead is essential for Nodal signaling","volume":"97","author":"Gritsman","year":"1999","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/(SICI)1096-9861(19990830)411:3&lt;441::AID-CNE7&gt;3.0.CO;2-N","article-title":"Nitric oxide synthase activity reveals an asymmetrical organization of the frog habenulae during development: A histochemical and cytoarchitectonic study from tadpoles to the mature Rana esculenta, with notes on the pineal complex","volume":"411","author":"Guglielmotti","year":"1999","journal-title":"J. Comp. Neurol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0092-8674(05)80087-X","article-title":"Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation","volume":"75","author":"Halpern","year":"1993","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/0149-7634(95)00077-1","article-title":"Diencephalic asymmetries","volume":"20","author":"Harris","year":"1996","journal-title":"Neurosci. Biobehav. Rev"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/350339a0","article-title":"The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system","volume":"350","author":"Hatta","year":"1991","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1006\/dbio.1997.8511","article-title":"The function of silberblick in positioning the eye anlage in the zebrafish embryo","volume":"184","author":"Heisenberg","year":"1997","journal-title":"Dev. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/oxfordjournals.jhered.a106870","article-title":"Visceral inversion and associated anomalies in the mouse","volume":"50","author":"Hummel","year":"1959","journal-title":"J. Hered"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0925-4773(99)00232-4","article-title":"Asymmetric expression of antivin\/lefty1 in the early chick embryo","volume":"90","author":"Ishimaru","year":"2000","journal-title":"Mech. Dev"},{"key":"2023030307470782300_","volume-title":"Structure and Function of the Epiphysis Cerebri","author":"Kappers","year":"1965"},{"key":"2023030307470782300_","first-page":"87","article-title":"Innervation of the vertebrate pineal organ","volume-title":"The Pineal Gland and Its Endocrine Role","author":"Kappers","year":"1982"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1212\/WNL.53.6.1260","article-title":"Structural and functional brain asymmetries in human situs inversus totalis","volume":"53","author":"Kennedy","year":"1999","journal-title":"Neurology"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"5749","DOI":"10.1242\/dev.126.24.5749","article-title":"Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism","volume":"126","author":"Kitamura","year":"1999","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1086\/302289","article-title":"Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development","volume":"64","author":"Kosaki","year":"1999","journal-title":"Am. J. Hum. Genet"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1016\/0092-8674(93)90628-4","article-title":"A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos","volume":"75","author":"Krauss","year":"1993","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/oxfordjournals.jhered.a108749","article-title":"Random determination of a developmental process: reversal of normal visceral asymmetry in the mouse","volume":"67","author":"Layton","year":"1976","journal-title":"J. Hered"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1749-6632.1976.tb25499.x","article-title":"Morphological cerebral asymmetries of modern man, fossil man, and nonhuman primate","volume":"280","author":"LeMay","year":"1976","journal-title":"Ann. New York Acad. Sci"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0166-2236(82)90170-9","article-title":"Morphological aspects of human brain asymmetry: an evolutionary perspective","volume":"5","author":"LeMay","year":"1982","journal-title":"Trends Neurosci"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/0092-8674(95)90477-8","article-title":"A molecular pathway determining left-right asymmetry in chick embryogenesis","volume":"82","author":"Levin","year":"1995","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/45803","article-title":"Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis","volume":"401","author":"Lin","year":"1999","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0092-8674(00)81474-9","article-title":"The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals","volume":"94","author":"Logan","year":"1998","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/381158a0","article-title":"Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus","volume":"381","author":"Lowe","year":"1996","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/45797","article-title":"Function of Rieger syndrome gene in left-right asymmetry and craniofacial development","volume":"401","author":"Lu","year":"1999","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1242\/dev.122.10.3275","article-title":"A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation","volume":"122","author":"Lustig","year":"1996","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0896-6273(01)80045-3","article-title":"floating head and masterblind regulate neuronal patterning in the roof of the forebrain","volume":"18","author":"Masai","year":"1997","journal-title":"Neuron"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/381151a0","article-title":"Left-right asymmetric expression of the TGFbeta-family member lefty in mouse embryos","volume":"381","author":"Meno","year":"1996","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1046\/j.1365-2443.1997.1400338.x","article-title":"Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos","volume":"2","author":"Meno","year":"1997","journal-title":"Genes Cells"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0092-8674(00)81472-5","article-title":"lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal","volume":"94","author":"Meno","year":"1998","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S1097-2765(00)80331-7","article-title":"Mouse Lefty2 and zebrafish Antivin are feedback inhibitors of Nodal signaling during vertebrate gastrulation","volume":"4","author":"Meno","year":"1999","journal-title":"Mol. Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0092-8674(00)81705-5","article-title":"Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein","volume":"95","author":"Nonaka","year":"1998","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1242\/dev.123.1.103","article-title":"Mutations affecting the formation of the notochord in the zebrafish, Danio rerio","volume":"123","author":"Odenthal","year":"1996","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1097-2765(00)80197-5","article-title":"Abnormal nodal flow precedes situs inversus in iv and inv mice","volume":"4","author":"Okada","year":"1999","journal-title":"Mol. Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0092-8674(00)81143-5","article-title":"The transfer of left-right positional information during chick embryogenesis","volume":"93","author":"Pagan-Westphal","year":"1998","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S0960-9822(99)80267-X","article-title":"Nodal signalling and the roles of the transcription factors SnR and Pitx2 in vertebrate left-right asymmetry","volume":"9","author":"Patel","year":"1999","journal-title":"Curr. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0092-8674(00)81475-0","article-title":"Pitx2 participates in the late phase of the pathway controlling left-right asymmetry","volume":"94","author":"Piedra","year":"1998","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0168-9525(98)01599-6","article-title":"Molecular mechanisms of vertebrate left-right development","volume":"14","author":"Ramsdell","year":"1998","journal-title":"Trends Genet"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1006\/dbio.1998.8935","article-title":"Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry","volume":"199","author":"Rebagliati","year":"1998","journal-title":"Dev. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"9932","DOI":"10.1073\/pnas.95.17.9932","article-title":"cyclops encodes a nodal-related factor involved in midline signaling","volume":"95","author":"Rebagliati","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/45738","article-title":"The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry","volume":"401","author":"Rodriguez-Esteban","year":"1999","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/29004","article-title":"Pitx2 determines left-right asymmetry of internal organs in vertebrates","volume":"394","author":"Ryan","year":"1998","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1242\/dev.122.6.1873","article-title":"Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions","volume":"122","author":"Sagerstrom","year":"1996","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S1097-2765(00)80401-3","article-title":"Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2","volume":"5","author":"Saijoh","year":"2000","journal-title":"Mol. Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1242\/dev.124.17.3293","article-title":"Functional differences among Xenopus nodal-related genes in left-right axis determination","volume":"124","author":"Sampath","year":"1997","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/26020","article-title":"Induction of the zebrafish ventral brain and floorplate requires cyclops\/nodal signalling","volume":"395","author":"Sampath","year":"1998","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dev.123.1.165","article-title":"Mutations affecting the development of the embryonic zebrafish brain","volume":"123","author":"Schier","year":"1996","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/35000126","article-title":"Nodal signalling in vertebrate development","volume":"403","author":"Schier","year":"2000","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1006\/dbio.1999.9214","article-title":"Regulation of left-right asymmetries in the zebrafish by Shh and BMP4","volume":"210","author":"Schilling","year":"1999","journal-title":"Dev. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/cne.903450107","article-title":"NADPH-diaphorase in the central nervous system of the larval lamprey (Lampetra planeri)","volume":"345","author":"Schober","year":"1994","journal-title":"J. Comp. Neurol"},{"key":"2023030307470782300_","first-page":"41","volume":"90","author":"Schweickert","year":"2000","journal-title":"Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry. Mech. Dev"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1006\/bbrc.1998.8740","article-title":"Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart looping","volume":"247","author":"St Amand","year":"1998","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2023030307470782300_","first-page":"26","article-title":"Novel expression pattern of Interphotoreceptor retinoid-binding protein (IRBP) in the adult and developing zebrafish retina and RPE","volume-title":"Mol. Vis","author":"Stenkamp","year":"1998"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/40140","article-title":"Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice","volume":"389","author":"Supp","year":"1997","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/378150a0","article-title":"A homeobox gene essential for zebrafish notochord development","volume":"378","author":"Talbot","year":"1995","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1242\/dev.119.4.1203","article-title":"Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail, and no-tail mutant embryos","volume":"119","author":"Thisse","year":"1993","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1242\/dev.126.2.229","article-title":"tAntivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction","volume":"126","author":"Thisse","year":"1999","journal-title":"Development"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/35000200","article-title":"Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo","volume":"403","author":"Thisse","year":"2000","journal-title":"Nature"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"11376","DOI":"10.1073\/pnas.96.20.11376","article-title":"Multiple left-right asymmetry defects in shh(\u2212\/\u2212). mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1","volume":"96","author":"Tsukui","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023030307470782300_","volume-title":"The Zebrafish Book. Eugene, OR: University of Oregon Press","author":"Westerfield","year":"1994"},{"key":"2023030307470782300_","first-page":"111","article-title":"Asymmetry in brain function follows asymmetry in anatomical form: gross, microscopic, postmortem and imaging studies","volume-title":"Handbook of Neuropsychology","author":"Witelson","year":"1988"},{"key":"2023030307470782300_","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-0348-8979-7","volume-title":"Neuroanatomy of the Zebrafish Brain: A Topological Atlas","author":"Wulliman","year":"1996"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1101\/gad.13.19.2527","article-title":"Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation","volume":"13","author":"Yan","year":"1999","journal-title":"Genes Dev"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s004410050621","article-title":"Central projections of the parapineal organ of the adult rainbow trout (Oncorhynchus mykiss)","volume":"285","author":"Yanez","year":"1996","journal-title":"Cell Tissue Res"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1006\/dbio.1999.9406","article-title":"Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish","volume":"214","author":"Yelon","year":"1999","journal-title":"Dev. Biol"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0092-8674(00)80045-8","article-title":"Antagonistic signaling by Caronte, a novel cerberus-related gene, establishes left-right asymmetric gene expression","volume":"98","author":"Yokouchi","year":"1999","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0092-8674(00)81473-7","article-title":"Pitx2, a bicoid-type homeobox gene, is involved in a Lefty-signaling pathway in determination of left-right asymmetry","volume":"94","author":"Yoshioka","year":"1998","journal-title":"Cell"},{"key":"2023030307470782300_","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0092-8674(00)80918-6","article-title":"Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation","volume":"92","author":"Zhang","year":"1998","journal-title":"Cell"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/127\/23\/5101\/2590551\/develop_127_23_5101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/127\/23\/5101\/2590551\/develop_127_23_5101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T18:40:51Z","timestamp":1698950451000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/127\/23\/5101\/41092\/Asymmetric-Nodal-signaling-in-the-zebrafish"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":94,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2000,12,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.127.23.5101","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,1]]}}}