{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:27:55Z","timestamp":1791095275520,"version":"4.1.0"},"reference-count":38,"publisher":"The Company of Biologists","issue":"24","license":[{"start":{"date-parts":[[2000,12,15]],"date-time":"2000-12-15T00:00:00Z","timestamp":976838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The Mi-2 protein is the central component of the recently isolated NuRD nucleosome remodelling and histone deacetylase complex. Although the NuRD complex has been the subject of extensive biochemical analyses, little is known about its biological function. Here we show that the two C. elegans Mi-2 homologues, LET-418 and CHD-3, play essential roles during development. The two proteins possess both shared and unique functions during vulval cell fate determination, including antagonism of the Ras signalling pathway required for vulval cell fate induction and the proper execution of the 2\u00b0 cell fate of vulval precursor cells, a process under the control of LIN-12 Notch signalling.<\/jats:p>","DOI":"10.1242\/dev.127.24.5277","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T20:10:27Z","timestamp":1619208627000},"page":"5277-5284","source":"Crossref","is-referenced-by-count":114,"title":["The <i>C. elegans<\/i> Mi-2 chromatin-remodelling proteins function in vulval cell fate determination"],"prefix":"10.1242","volume":"127","author":[{"given":"Thomas von","family":"Zelewsky","sequence":"first","affiliation":[{"name":"Institute of Zoology 1 , Department of Biology, University of Fribourg, P\u00e9rolles, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Palladino","sequence":"additional","affiliation":[{"name":"Institute of Zoology 1 , Department of Biology, University of Fribourg, P\u00e9rolles, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Brunschwig","sequence":"additional","affiliation":[{"name":"Institute of Zoology 1 , Department of Biology, University of Fribourg, P\u00e9rolles, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Tobler","sequence":"additional","affiliation":[{"name":"Institute of Zoology 1 , Department of Biology, University of Fribourg, P\u00e9rolles, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hajnal","sequence":"additional","affiliation":[{"name":"Division of Cancer Research 2 , Department of Pathology, University of Zurich, Schmelzbergstr. 12, CH-8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Zoology 1 , Department of Biology, University of Fribourg, P\u00e9rolles, CH-1700 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2000,12,15]]},"reference":[{"key":"2023051123344889500_DEVELOP_127_24_5277C1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0168-9525(00)02066-7","article-title":"NuRD and SIN3 histone deacetylase complexes in development","volume":"16","author":"Ahringer","year":"2000","journal-title":"Trends Genet"},{"key":"2023051123344889500_DEVELOP_127_24_5277C2","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1242\/dev.126.9.1947","article-title":"Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells","volume":"126","author":"Ambros","year":"1999","journal-title":"Development"},{"key":"2023051123344889500_DEVELOP_127_24_5277C3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2023051123344889500_DEVELOP_127_24_5277C4","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1242\/dev.125.6.1083","article-title":"EGL-17(FGF) expression coordinates the attraction of the migrating sex myoblasts with vulval induction in C. elegans","volume":"125","author":"Burdine","year":"1998","journal-title":"Development"},{"key":"2023051123344889500_DEVELOP_127_24_5277C5","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1073\/pnas.90.6.2414","article-title":"A mammalian DNA-binding protein that contains a chromodomain and an SNF2\/ SWI2-like helicase domain","volume":"90","author":"Delmas","year":"1993","journal-title":"Proc. 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