{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:20:12Z","timestamp":1791300012031,"version":"4.1.0"},"reference-count":59,"publisher":"The Company of Biologists","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:p>Pax3 is a member of the paired-box-containing transcription factors. It is expressed in the developing somites, dorsal spinal cord, mesencephalon and neural crest derivatives. Several loss-of-function mutations are correlated with the Splotch phenotype in mice and Waardenburg syndrome in humans. Malformations include a lack of muscle in the limb, a failure of neural tube closure and dysgenesis of numerous neural crest derivatives. In this study we have used embryonic stem (ES) cells to generate a lacZ knock-in into the Pax3 locus. The Pax3 knock-in Splotch allele (Sp2G) was used to generate Pax3-deficient ES cells in order to investigate whether, in chimeric embryos, Pax3 is acting cell autonomously in the somites and the neural tube. We found that while Pax3 function is essential for the neuroepithelium and somites, a wild-type environment rescues mutant neural crest cells. In the two affected embryonic tissues, mutant and wild-type cells undergo segregation and do not intermingle.<\/jats:p><jats:p>The contribution of mutant cells to the neural tube and the somites displayed temporal differences. All chimeric embryos showed a remarkable contribution of blue cells to the neural tube at all stages analyzed, indicating that the Pax3-deficient cells are not excluded from the neural epithelium while development proceeds. In contrast, this is not true for the paraxial mesoderm. The somite contribution of Pax3\u2212\/\u2212 ES cells becomes less frequent in older embryos as compared to controls with Pax3+\/\u2212 ES cells. We propose that although Pax3 function is related to cell surface properties, its role may differ in various tissues. In fact, apoptosis was found in Pax3-deficient cells of the lateral dermomyotome but not in the neural tube.<\/jats:p>","DOI":"10.1242\/dev.128.11.1995","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T05:50:53Z","timestamp":1619416253000},"page":"1995-2005","source":"Crossref","is-referenced-by-count":54,"title":["<i>Pax3<\/i>acts cell autonomously in the neural tube and somites by controlling cell surface properties"],"prefix":"10.1242","volume":"128","author":[{"given":"Ahmed","family":"Mansouri","sequence":"first","affiliation":[{"name":"Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D-37077 Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pla","sequence":"additional","affiliation":[{"name":"Ge\u0301ne\u0301tique du De\u0301veloppement des Me\u0301lanocytes, Institut CURIE \u2013 Section Recherche, UMR146 CNRS, Bat 110, Centre Universitaire, F-91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Larue","sequence":"additional","affiliation":[{"name":"Ge\u0301ne\u0301tique du De\u0301veloppement des Me\u0301lanocytes, Institut CURIE \u2013 Section Recherche, UMR146 CNRS, Bat 110, Centre Universitaire, F-91405 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gruss","sequence":"additional","affiliation":[{"name":"Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D-37077 Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042604571454700_ALLEN-ETAL-1988","doi-asserted-by":"crossref","unstructured":"Allen, N. D., Cran, D. G., Barton, S. C., Hettle, S., Reik, W. and Surani, M. A. (1988). Transgenes as probes for active chromosomal domains in mouse development. Nature333, 852-855.","DOI":"10.1038\/333852a0"},{"key":"2021042604571454700_AUERBACH-1954","doi-asserted-by":"crossref","unstructured":"Auerbach, R. (1954). Analysis of the developmental effects of a lethal mutation in the house mouse. J. Exp. Zool.127, 305-329.","DOI":"10.1002\/jez.1401270206"},{"key":"2021042604571454700_AMTHOR-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Amthor, H., Christ, B. and Patel, K. (1999). A molecular mechanism enabling continuous embryonic muscle growth \u2013 balance between proliferation and differentiation. Development126, 1041-1053.","DOI":"10.1242\/dev.126.5.1041"},{"key":"2021042604571454700_BEAUVAIS-JOUNEAU-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Beauvais-Jouneau, A., Pla, P., Bernex, F., Dufour, S., Salamero, J., Fassler, R., Panthier, J. J., Thiery, J. P. and Larue, L. (1999). A novel model to study the dorsolateral migration of melanoblasts. Mech. Dev.89,3-14.","DOI":"10.1016\/S0925-4773(99)00191-4"},{"key":"2021042604571454700_BERNASCONI-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Bernasconi, A., Remppis, A., Fredericks, W. J., Rauscher, F. J. and Scha\u0308fer, B. W. (1996). Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. Proc. Natl. Acad. Sci. USA93, 13164-13169.","DOI":"10.1073\/pnas.93.23.13164"},{"key":"2021042604571454700_BLADT-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. and Birchmeier, C. (1995). Essential role for the c-met receptor in the migration of myogenic precursor cells in the limb bud. Nature376, 768-771.","DOI":"10.1038\/376768a0"},{"key":"2021042604571454700_BOBER-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Bober, E., Franz, T., Arnold, H.-H., Gruss, P. and Tremblay, P. (1994). Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development120, 603-612.","DOI":"10.1242\/dev.120.3.603"},{"key":"2021042604571454700_BORYCKI-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Borycki, A.-G., Li, J., Jin, F., Emerson, C. P. J. and Epstein, J. A. (1999). Pax3 functions in cell survival and in Pax7 regulation. Development126, 1665-1674.","DOI":"10.1242\/dev.126.8.1665"},{"key":"2021042604571454700_BRAND-SABERI-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Brand-Saberi, B., Gamel, A. J., Krenn, V., Mu\u0308ller, T. S., Wilting, J. and Christ, B. (1996). N-cadherin is involved in myoblast migration and muscle differentiation in the avian limb bud. Dev. Biol.178, 160-173.","DOI":"10.1006\/dbio.1996.0206"},{"key":"2021042604571454700_CHALEPAKIS-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Chalepakis, G., Wijnholds, J., Giese, P., Schachner, M. and Gruss, P. (1994). Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. DNA Cell Biol.13, 891-900.","DOI":"10.1089\/dna.1994.13.891"},{"key":"2021042604571454700_CHRIST-AND-ORDAHL-1995","doi-asserted-by":"crossref","unstructured":"Christ, B. and Ordahl, C. P. (1995). Early stages of chick somite development. Anat. Embryol.191, 381-396.","DOI":"10.1007\/BF00304424"},{"key":"2021042604571454700_CIRUNA-ETAL-1997","unstructured":"Ciruna, B. N., Schwarz, L., Harpal, K., Yamaguchi, T.P. and Rossant, J. (1997) Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr-1) function: A role in morphogenetic movement through the primitive streak. Development124, 2829-2841."},{"key":"2021042604571454700_COLLINSON-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Collinson, J. M., Hill, R. E. and West, J. D. (2000). Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development127, 945-956.","DOI":"10.1242\/dev.127.5.945"},{"key":"2021042604571454700_COTRINA-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Cotrina, M. L., Gonza\u0301lez-Hoyuela, M., Barbas, J. A. and Rodri\u0301guez-Te\u0301bar A. (2000). Programmed Cell Death in the Developing Somites Is Promoted by Nerve Growth Factor via Its p75NTR Receptor. Dev. Biol.228, 326-336.","DOI":"10.1006\/dbio.2000.9948"},{"key":"2021042604571454700_CURRIE-AND-INGHAM-1998","doi-asserted-by":"crossref","unstructured":"Currie, P. D. and Ingham, P. W. (1998). The generation and interpretation of positional information within the vertebrate myotome. Mech. Dev.73, 3-21.","DOI":"10.1016\/S0925-4773(98)00036-7"},{"key":"2021042604571454700_DASTON-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Daston, G., Lamar, E. and M., G. (1996). Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development122, 1017-1027.","DOI":"10.1242\/dev.122.3.1017"},{"key":"2021042604571454700_DUNCAN-ETAL-2000","unstructured":"Duncan, M. K., Kozmik, Z., Cveklova, K., Piatigorsky, J. and Cvekl, A. (2000). Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of a5b1 integrin expression. Development13,3173-3185."},{"key":"2021042604571454700_EPSTEIN-ETAL-1991","doi-asserted-by":"crossref","unstructured":"Epstein, D. J., Vekemans, M. and Gros, P. (1991). splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell67, 767-774.","DOI":"10.1016\/0092-8674(91)90071-6"},{"key":"2021042604571454700_EPSTEIN-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Epstein, J. A., Shapiro, D. N., Cheng, J., Lam, P. Y. and Maas, R. L. (1996). Pax3 modulates expression of the c-met receptor during limb muscle development. Proc. Natl. Acad. Sci. USA93, 4213-4218.","DOI":"10.1073\/pnas.93.9.4213"},{"key":"2021042604571454700_EPSTEIN-ETAL-2000","unstructured":"Epstein, J. A., Li, J., Lang, D., Chen, F., Braun, C. B., Jin, F., Min Lu, M., Thomas, M., Liu, E.-C. J., Wessels, A. and Lo, C. W. (2000). Migration of cardiac neiral crest cells in Splotch embryos. Development127, 1869-1878."},{"key":"2021042604571454700_FRANZ-1989","doi-asserted-by":"crossref","unstructured":"Franz, T. (1989). Persistent truncus arteriosus in the splotch mutant mouse. Anat. Embryol.180, 457-464.","DOI":"10.1007\/BF00305120"},{"key":"2021042604571454700_FRANZ-AND-KOTHARY-1993","doi-asserted-by":"crossref","unstructured":"Franz, T. and Kothary, R. (1993). Characterization of the neural crest defect in Splotch (Sp1H) mutant mice using a lacZ transgene. Dev. Brain Res.72, 99-105.","DOI":"10.1016\/0165-3806(93)90163-5"},{"key":"2021042604571454700_FRANZ-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Franz, T., Kothary, R., Surani, M. A. H. and Grim, M. (1993). The Splotch mutation interferes with muscle development in the limbs. Anat. Embryol.187, 153-160.","DOI":"10.1007\/BF00171747"},{"key":"2021042604571454700_GOULDING-ETAL-1991","doi-asserted-by":"crossref","unstructured":"Goulding, M. D., Chalepkis, G., Deutsch, U., Erselius, J. R. and Gruss, P. (1991). Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J.10, 1135-1147.","DOI":"10.1002\/j.1460-2075.1991.tb08054.x"},{"key":"2021042604571454700_GOULDING-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Goulding, M., Lumsden, A. and Paquette, A. J. (1994). Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development120, 957-971.","DOI":"10.1242\/dev.120.4.957"},{"key":"2021042604571454700_HENDERSON-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Henderson, D. J., Ybot-Gonzalez, P. and Copp, A. J. (1997). Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (Splotch). Mech. Dev.69, 39-51.","DOI":"10.1016\/S0925-4773(97)00151-2"},{"key":"2021042604571454700_HIRSINGER-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Hirsinger, E., Duprez, D., Jouve, C., Malapert, P., Cooke, J. and Pourquie\u0301 (1997). Noggin acts downstream of Wnt and sonic Hedgehog to antagonize BMP4 in avian somite patterning. Development124, 4605-4614.","DOI":"10.1242\/dev.124.22.4605"},{"key":"2021042604571454700_HOGAN-ETAL-1994","unstructured":"Hogan, B. L. M., Constantini, F. and Lacy, E. (1994). Manipulating The Mouse Embryo: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press."},{"key":"2021042604571454700_KOZMIK-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Kozmik, Z., Wang, S., Do\u0308rfler, P., Adams, B. and Busslinger, M. (1992). The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell. Biol.12, 2662-2672.","DOI":"10.1128\/MCB.12.6.2662"},{"key":"2021042604571454700_LABONNE-AND-BRONNER-FRASER-1999","doi-asserted-by":"crossref","unstructured":"LaBonne, C. and Bronner-Fraser, M. (1999). Molecular mechanisms of neural crest formation. Annu. Rev. Cell Dev. Biol.15, 81-112.","DOI":"10.1146\/annurev.cellbio.15.1.81"},{"key":"2021042604571454700_LI-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Li, J., Liu, K. C., Jin, F., Lu, M. M. and Epstein, J. A. (1999). Transgenic rescue of congenital heart disease and spina bifida in Splotch mice. Development126,2495-2503.","DOI":"10.1242\/dev.126.11.2495"},{"key":"2021042604571454700_MANSOURI-ETAL-1996A","doi-asserted-by":"crossref","unstructured":"Mansouri, A., Hallonet, M. and Gruss, P. (1996a). Pax genes and their role in cell differentiation and development. Curr. Opin. Cell Biol.8, 851-857.","DOI":"10.1016\/S0955-0674(96)80087-1"},{"key":"2021042604571454700_MANSOURI-ETAL-1996B","doi-asserted-by":"crossref","unstructured":"Mansouri, A., Stoykova, A., Torres, M. and Gruss, P. (1996b). Dysgenesis of cephalic neural crest derivatives in Pax 7-\/- mutant mice. Development122, 831-838.","DOI":"10.1242\/dev.122.3.831"},{"key":"2021042604571454700_MANSOURI-AND-GRUSS-1998","doi-asserted-by":"crossref","unstructured":"Mansouri, A. and Gruss, P. (1998). Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord. Mech. Dev.78, 171-178.","DOI":"10.1016\/S0925-4773(98)00168-3"},{"key":"2021042604571454700_MARCELLE-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Marcelle, C., Stark, M. R. and Bronner-Fraser, M. (1997). Coordinate actions of BMPs, Wnts, Shh and Noggin mediate patterning of the dorsal somite. Development124, 3955-3963.","DOI":"10.1242\/dev.124.20.3955"},{"key":"2021042604571454700_MAROTO-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Maroto, M., Reshef, R., Mu\u0308nsterberg, A., Koester, S., Goulding, M. and Lassar, A. (1997). Ectopic Pax-3 activates MyoD and MyF5 expression in embryonic mesoderm and neural tissue. Cell89, 139-184.","DOI":"10.1016\/S0092-8674(00)80190-7"},{"key":"2021042604571454700_MENNERICH-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Mennerich, D., Schaefer, K. and Braun, T. (1998). Pax3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb. Mech. Dev.73, 147-158.","DOI":"10.1016\/S0925-4773(98)00046-X"},{"key":"2021042604571454700_MOASE-AND-TRASLER-1989","doi-asserted-by":"crossref","unstructured":"Moase, C. E. and Trasler, D. G. (1989). Spinal ganglia reduction in the Splotch-delayed mouse neural tube defect mutant. Teratology40, 67-75.","DOI":"10.1002\/tera.1420400109"},{"key":"2021042604571454700_MOASE-AND-TRASLER-1990","doi-asserted-by":"crossref","unstructured":"Moase, C. E. and Trasler, D. G. (1990). Delayed neural crest emigration from Sp and Spd mouse neural tube explants. Teratology42, 171-182.","DOI":"10.1002\/tera.1420420208"},{"key":"2021042604571454700_MOASE-AND-TRASLER-1991","doi-asserted-by":"crossref","unstructured":"Moase, C. E. and Trasler, D. G. (1991). N-CAM alterations in splotch neural tube defect mouse embryos. Development113, 1049-1058.","DOI":"10.1242\/dev.113.3.1049"},{"key":"2021042604571454700_MUUMLNSTERBERG-ETAL-1995","doi-asserted-by":"crossref","unstructured":"Mu\u0308nsterberg, A. E., Kitajewski, J., Bumcrot, D. A., McMahon, A. P. and Lassner, A. B. (1995). Combinatorial signaling by sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev.9, 2911-2922.","DOI":"10.1101\/gad.9.23.2911"},{"key":"2021042604571454700_POURQUIEACUTE-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Pourquie\u0301, O., Fan, C. M., Coltey, M., Hirsinger, E., Watanabe, Y., Breant, C., Francis-West, P., Tessier-Lavigne, M. and Le Douarin, N. M. (1996). Lateral and axial signals involved in avian somite patterning: a role for BMP4. Cell84, 461-471.","DOI":"10.1016\/S0092-8674(00)81291-X"},{"key":"2021042604571454700_QUINN-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Quinn, J. C., West, J. D. and Hill, R. E. (1996). Multiple function for Pax6 in mouse eye and nasal development. Genes Dev.10, 435-446.","DOI":"10.1101\/gad.10.4.435"},{"key":"2021042604571454700_RESHEF-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Reshef, R., Maroto, M. and Lassar, B. L. (1998). Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. Genes Dev.12, 290-303.","DOI":"10.1101\/gad.12.3.290"},{"key":"2021042604571454700_ROSSANT-AND-SPENCE-1998","doi-asserted-by":"crossref","unstructured":"Rossant, J. and Spence, A. (1998). Chimeras and mosaics in the mouse. Trends Genet.14, 358-363.","DOI":"10.1016\/S0168-9525(98)01552-2"},{"key":"2021042604571454700_SERBEDZIJA-AND-MCMAHON-1997","doi-asserted-by":"crossref","unstructured":"Serbedzija, G. N. and McMahon, A. P. (1997). Analysis of neural crest cell migration in Splotch mice using a neural crest-specific LacZ reporter. Dev. Biol.185, 139-147.","DOI":"10.1006\/dbio.1997.8551"},{"key":"2021042604571454700_ST-ONGE-ETAL-1997","doi-asserted-by":"crossref","unstructured":"St Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A. and Gruss, P. (1997). Pax6 is required for differentiation of glucagon-producing \u03b1-cells in mouse pancreas. Nature387, 406-409.","DOI":"10.1038\/387406a0"},{"key":"2021042604571454700_STOYKOVA-ETAL-1997","unstructured":"Stoykova, A., Go\u0308tz, M., Gruss, P. and Price, J. (1997). Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forbrain. Development124, 3765-3777."},{"key":"2021042604571454700_SUN-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Sun, X., Meyers, E. N., Lewandoski, M. and Martin, G. R. (1999). Targeted disruption of FGF8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev.13, 1834-1846.","DOI":"10.1101\/gad.13.14.1834"},{"key":"2021042604571454700_TAJBAKHSH-ETAL-1997","doi-asserted-by":"crossref","unstructured":"Tajbakhsh, S., Rocancourt, D., Cossu, G. and Buckingham, M. (1997). Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and MyF-5 act upstream of MyoD. Cell89, 127-138.","DOI":"10.1016\/S0092-8674(00)80189-0"},{"key":"2021042604571454700_TAJBAKHSH-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Tajbakhsh, S., Borello, U., Vivarelli, E., Kelly, R., Papkoff, J., Duprez, D., Buckingham, M. and Cossu, G. (1998). Differential activation of MyF5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5. Development125, 4155-4162.","DOI":"10.1242\/dev.125.21.4155"},{"key":"2021042604571454700_TAKEICHI-1991","doi-asserted-by":"crossref","unstructured":"Takeichi, M. (1991). Cadherin cell adhesion receptors as a morphogenetic regulator. Science251, 1451-1455.","DOI":"10.1126\/science.2006419"},{"key":"2021042604571454700_TASSABEHJI-ETAL-1992","doi-asserted-by":"crossref","unstructured":"Tassabehji, M., Read, A. P., Newton, V. E., Harris, R., Balling, R., Gruss, P. and Strachan, T. (1992). Waardenburg\u2019s syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature355, 635-636.","DOI":"10.1038\/355635a0"},{"key":"2021042604571454700_TASSABEHJI-ETAL-1993","doi-asserted-by":"crossref","unstructured":"Tassabehji, M., Read, A. P., Newton, V. E., Patton, M., Gruss, P., Harris, R. and Strachan, T. (1993). Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2. Nat. Genet.3, 26-30.","DOI":"10.1038\/ng0193-26"},{"key":"2021042604571454700_TRUMPP-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Trumpp, A., Depew, M. J., Rubenstein, J. L. R., Bishop, J. M. and Martin, S. G. R. (1999). Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev.13, 3136-3148.","DOI":"10.1101\/gad.13.23.3136"},{"key":"2021042604571454700_WILLIAMS-AND-ORDAHL-1994","doi-asserted-by":"crossref","unstructured":"Williams, B. A. and Ordahl, C. P. (1994). Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification. Development120, 785-796.","DOI":"10.1242\/dev.120.4.785"},{"key":"2021042604571454700_WEST-1999","unstructured":"West, J. D. (1999). Insights into development and genetics from mouse chimeras. Curr. Topics Dev. Biol.44, 21-66."},{"key":"2021042604571454700_YAMAGUCHI-1997","doi-asserted-by":"crossref","unstructured":"Yamaguchi, T. P. (1997). New insights into segmentation and patterning during vertebrate somitogenesis. Curr. Opin. Genet. Dev.7, 513-518.","DOI":"10.1016\/S0959-437X(97)80079-2"},{"key":"2021042604571454700_YANG-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Yang, X.-M., Vogan, K., Gros, P. and Park, M. (1996). Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice. Development122, 2163-2171.","DOI":"10.1242\/dev.122.7.2163"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/128\/11\/1995\/1136783\/1995.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/128\/11\/1995\/1136783\/1995.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T12:02:45Z","timestamp":1671969765000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/128\/11\/1995\/41292\/Pax3-acts-cell-autonomously-in-the-neural-tube-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2001,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.128.11.1995","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6,1]]}}}