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Knockout mice show increased rates of oligodendrocyte precursor migration along the optic nerve and reduced rates of oligodendrocyte precursor proliferation in different regions of the CNS. Levels of programmed cell death were reduced in areas of myelination at later developmental stages,providing a potential corrective mechanism for any reduction in cell numbers that resulted from the proliferation phenotype. The effects on cell proliferation are mediated via the \u03b1v\u03b23 integrin and an interaction with the platelet-derived growth factor-stimulated mitogenic pathway, emphasising the importance of both CNS extracellular matrix and integrin growth factor interactions in the regulation of neural precursor behaviour.<\/jats:p>","DOI":"10.1242\/dev.128.13.2485","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T12:57:57Z","timestamp":1619355477000},"page":"2485-2496","source":"Crossref","is-referenced-by-count":196,"title":["Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration"],"prefix":"10.1242","volume":"128","author":[{"given":"Emmanuel","family":"Garcion","sequence":"first","affiliation":[{"name":"Department of Medical Genetics and Cambridge Center for Brain Repair, University of Cambridge, The E.D. 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