{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:41:51Z","timestamp":1790365311580,"version":"4.1.0"},"reference-count":63,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Scho 503\/12-1"],"award-info":[{"award-number":["Scho 503\/12-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Wi774\/27-1"],"award-info":[{"award-number":["Wi774\/27-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>Loss of Tfap2c leads to developmental defects in the extra-embryonic compartment with embryonic lethality at E7.5. To investigate requirement of Tfap2c in later placental development, deletion of Tfap2c was induced throughout extra-embryonic ectoderm at E6.5 leading to severe placental abnormalities caused by reduced trophoblast population resulting in embryonic retardation by E8.5. Deletion of Tfap2c in Tpbpa+ progenitors at E8.5 results in growth arrest of junctional zone. TFAP2C regulates its target genes p21\/Cdkn1a and Dusp6, involved in repression of MAPK signaling. Loss of TFAP2C reduces activation of ERK1\/2 in the placenta. Downregulation of Akt and reduced activation of pAKT in the mutant placenta are accompanied by impaired glycogen synthesis. Loss of Tfap2c led to upregulation of imprinted gene H19 and downregulation of Tex19.1 and Ascl2. The placental insufficiency post E16.5 causes fetal growth restriction with 19% lighter mutant pups. TFAP2C knockdown in human trophoblast choriocarcinoma JAr cells inhibited MAPK and AKT signaling. Thus, we present a model where Tfap2c in trophoblasts controls proliferation by repressing P21 and activating MAPK pathway and further supporting differentiation of glycogen cells via activating Akt pathway.<\/jats:p>","DOI":"10.1242\/dev.128553","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T22:39:12Z","timestamp":1453761552000},"source":"Crossref","is-referenced-by-count":27,"title":["Tpbpa mediated deletion of Tfap2c leads to deregulation of MAPK, P21, AKT and subsequent placental growth arrest"],"prefix":"10.1242","author":[{"given":"Neha","family":"Sharma","sequence":"first","affiliation":[{"name":"Institute of Pathology, Department of Developmental Pathology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kubaczka","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Department of Developmental Pathology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, University of Duisburg-Essen Medical School, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nettersheim","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Department of Developmental Pathology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaf S.","family":"Mughal","sequence":"additional","affiliation":[{"name":"Div. Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"National Center for Tumor Diseases (NCT), Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Riesenberg","sequence":"additional","affiliation":[{"name":"Unit of RNA Biology, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"H\u00f6lzel","sequence":"additional","affiliation":[{"name":"Unit of RNA Biology, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Winterhager","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, University of Duisburg-Essen Medical School, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Schorle","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Department of Developmental Pathology, University of Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608430353500_DEV128553C1","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"Adamson","year":"2002","journal-title":"Dev. Biol."},{"key":"2021042608430353500_DEV128553C2","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/j.1471-0528.1981.tb00983.x","article-title":"Morphologic characteristics of the normal term human trophoblast maintained in prolonged in vitro cultures","volume":"88","author":"Aladjem","year":"1981","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"2021042608430353500_DEV128553C3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/77076","article-title":"The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta","volume":"25","author":"Anson-Cartwright","year":"2000","journal-title":"Nat. Genet."},{"key":"2021042608430353500_DEV128553C4","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1053\/j.semperi.2008.02.006","article-title":"Vasculogenesis and angiogenesis in the IUGR placenta","volume":"32","author":"Arroyo","year":"2008","journal-title":"Semin. Perinatol."},{"key":"2021042608430353500_DEV128553C5","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1242\/dev.129.11.2733","article-title":"Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development","volume":"129","author":"Auman","year":"2002","journal-title":"Development"},{"key":"2021042608430353500_DEV128553C6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1600-0412.2004.00277.x","article-title":"Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies","volume":"83","author":"Bersinger","year":"2004","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"2021042608430353500_DEV128553C7","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1210\/en.2010-0936","article-title":"Transcription factor AP-2alpha promotes EGF-dependent invasion of human trophoblast","volume":"152","author":"Biadasiewicz","year":"2011","journal-title":"Endocrinology"},{"key":"2021042608430353500_DEV128553C8","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1242\/dev.120238","article-title":"Transcription factor AP-2gamma induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage","volume":"142","author":"Cao","year":"2015","journal-title":"Development"},{"key":"2021042608430353500_DEV128553C9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1002\/mrd.1080340403","article-title":"Progressive expression of trophoblast-specific genes during formation of mouse trophoblast giant cells in vitro","volume":"34","author":"Carney","year":"1993","journal-title":"Mol. Reprod. Dev."},{"key":"2021042608430353500_DEV128553C10","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1242\/dev.086645","article-title":"Transcription factor AP-2gamma is a core regulator of tight junction biogenesis and cavity formation during mouse early embryogenesis","volume":"139","author":"Choi","year":"2012","journal-title":"Development"},{"key":"2021042608430353500_DEV128553C11","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1002\/dvdy.20981","article-title":"Origin and characteristics of glycogen cells in the developing murine placenta","volume":"235","author":"Coan","year":"2006","journal-title":"Dev. Dyn."},{"key":"2021042608430353500_DEV128553C12","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.ydbio.2013.07.017","article-title":"Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality","volume":"382","author":"Crish","year":"2013","journal-title":"Dev. Biol."},{"key":"2021042608430353500_DEV128553C13","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"2021042608430353500_DEV128553C14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1749-6632.2003.tb03212.x","article-title":"Chorioallantoic morphogenesis and formation of the placental villous tree","volume":"995","author":"Cross","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021042608430353500_DEV128553C15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1113\/jphysiol.2005.089326","article-title":"ERK1\/2 and p38 regulate trophoblasts differentiation in human term placenta","volume":"566","author":"Daoud","year":"2005","journal-title":"J. Physiol."},{"key":"2021042608430353500_DEV128553C16","doi-asserted-by":"publisher","first-page":"C305","DOI":"10.1152\/ajpcell.00258.2005","article-title":"SNAT4 isoform of system A amino acid transporter is expressed in human placenta","volume":"290","author":"Desforges","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2021042608430353500_DEV128553C17","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1101\/gad.12.22.3499","article-title":"Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization","volume":"12","author":"Diehl","year":"1998","journal-title":"Genes Dev."},{"key":"2021042608430353500_DEV128553C18","doi-asserted-by":"publisher","first-page":"32172","DOI":"10.1074\/jbc.M112.393462","article-title":"Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein","volume":"287","author":"Dong","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2021042608430353500_DEV128553C19","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/bioinformatics\/btn224","article-title":"lumi: a pipeline for processing Illumina microarray","volume":"24","author":"Du","year":"2008","journal-title":"Bioinformatics"},{"key":"2021042608430353500_DEV128553C20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/gb-2005-6-13-246","article-title":"The AP-2 family of transcription factors","volume":"6","author":"Eckert","year":"2005","journal-title":"Genome Biol."},{"key":"2021042608430353500_DEV128553C21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2021042608430353500_DEV128553C22","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.placenta.2009.05.004","article-title":"Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations","volume":"30","author":"Esquiliano","year":"2009","journal-title":"Placenta"},{"key":"2021042608430353500_DEV128553C23","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1242\/dev.036061","article-title":"H19 acts as a trans regulator of the imprinted gene network controlling growth in mice","volume":"136","author":"Gabory","year":"2009","journal-title":"Development"},{"key":"2021042608430353500_DEV128553C24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2013.08.005","article-title":"The transcriptional co-repressor TLE3 regulates development of trophoblast giant cells lining maternal blood spaces in the mouse placenta","volume":"382","author":"Gasperowicz","year":"2013","journal-title":"Dev. Biol."},{"issue":"Suppl. A","key":"2021042608430353500_DEV128553C25","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1053\/plac.2002.0773","article-title":"The role of the placenta in fetal programming-a review","volume":"23","author":"Godfrey","year":"2002","journal-title":"Placenta"},{"key":"2021042608430353500_DEV128553C26","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/371333a0","article-title":"Essential role of Mash-2 in extraembryonic development","volume":"371","author":"Guillemot","year":"1994","journal-title":"Nature"},{"key":"2021042608430353500_DEV128553C27","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.ydbio.2004.03.040","article-title":"Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells","volume":"271","author":"Hemberger","year":"2004","journal-title":"Dev. Biol."},{"key":"2021042608430353500_DEV128553C28","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ydbio.2011.07.036","article-title":"Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta","volume":"358","author":"Hu","year":"2011","journal-title":"Dev. Biol."},{"key":"2021042608430353500_DEV128553C29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1095\/biolreprod.114.126474","article-title":"Reduced gene dosage of Tfap2c impairs trophoblast lineage differentiation and alters maternal blood spaces in the mouse placenta","volume":"93","author":"Kaiser","year":"2015","journal-title":"Biol. Reprod."},{"key":"2021042608430353500_DEV128553C30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s10555-008-9123-1","article-title":"Dual-specificity MAP kinase phosphatases (MKPs) and cancer","volume":"27","author":"Keyse","year":"2008","journal-title":"Cancer Metastasis Rev."},{"key":"2021042608430353500_DEV128553C31","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1101\/gr.101469.109","article-title":"Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance","volume":"20","author":"Kidder","year":"2010","journal-title":"Genome Res."},{"key":"2021042608430353500_DEV128553C32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0301-2115(00)00423-1","article-title":"Development of the placental villous tree and its consequences for fetal growth","volume":"92","author":"Kingdom","year":"2000","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"2021042608430353500_DEV128553C33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1053\/plac.2002.0880","article-title":"Expression and activation of MAP kinases, ERK1\/2, in the human villous trophoblasts","volume":"24","author":"Kita","year":"2003","journal-title":"Placenta"},{"key":"2021042608430353500_DEV128553C34","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1210\/en.2008-1645","article-title":"Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line","volume":"150","author":"Kotani","year":"2009","journal-title":"Endocrinology"},{"key":"2021042608430353500_DEV128553C35","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1432-1033.1996.0280r.x","article-title":"Coordinate expression of splice variants of the murine pregnancy-specific glycoprotein (PSG) gene family during placental development","volume":"242","author":"Kromer","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"2021042608430353500_DEV128553C36","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.stemcr.2013.12.013","article-title":"Derivation and maintenance of murine trophoblast stem cells under defined conditions","volume":"2","author":"Kubaczka","year":"2014","journal-title":"Stem Cell Rep."},{"key":"2021042608430353500_DEV128553C37","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1128\/MCB.01215-09","article-title":"The transcription factor TCFAP2C\/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation","volume":"30","author":"Kuckenberg","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"2021042608430353500_DEV128553C38","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.rbmo.2012.02.015","article-title":"The role of transcription factor Tcfap2c\/TFAP2C in trophectoderm development","volume":"25","author":"Kuckenberg","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"2021042608430353500_DEV128553C39","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1101\/gad.2.12a.1639","article-title":"Isolation and characterization of a novel trophoblast-specific cDNA in the mouse","volume":"2","author":"Lescisin","year":"1988","journal-title":"Genes Dev."},{"key":"2021042608430353500_DEV128553C40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3892\/etm.2011.392","article-title":"Association of SLC38A4 and system A with abnormal fetal birth weight","volume":"3","author":"Li","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"2021042608430353500_DEV128553C41","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1093\/nar\/gkm1075","article-title":"Model-based variance-stabilizing transformation for Illumina microarray data","volume":"36","author":"Lin","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2021042608430353500_DEV128553C42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1152\/jappl.1970.28.2.234","article-title":"Determination of glycogen in small tissue samples","volume":"28","author":"Lo","year":"1970","journal-title":"J. Appl. Physiol."},{"key":"2021042608430353500_DEV128553C43","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.placenta.2003.10.010","article-title":"Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies","volume":"25","author":"Mayhew","year":"2004","journal-title":"Placenta"},{"key":"2021042608430353500_DEV128553C44","doi-asserted-by":"publisher","first-page":"e82881","DOI":"10.1371\/journal.pone.0082881","article-title":"Analysis of TET expression\/activity and 5mC oxidation during normal and malignant germ cell development","volume":"8","author":"Nettersheim","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042608430353500_DEV128553C45","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ydbio.2011.01.008","article-title":"Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction","volume":"351","author":"Oh-McGinnis","year":"2011","journal-title":"Dev. Biol."},{"key":"2021042608430353500_DEV128553C46","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1749-6632.1971.tb34942.x","article-title":"The hormone-synthesizing trophoblastic cell in vitro: a model for cancer research and placental hormone synthesis","volume":"172","author":"Pattillo","year":"1971","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2021042608430353500_DEV128553C47","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2009.06.001","article-title":"CTCF: master weaver of the genome","volume":"137","author":"Phillips","year":"2009","journal-title":"Cell"},{"key":"2021042608430353500_DEV128553C48","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1002\/pd.2408","article-title":"First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome","volume":"29","author":"Pihl","year":"2009","journal-title":"Prenat. Diagn."},{"key":"2021042608430353500_DEV128553C49","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/gene.20025","article-title":"A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination","volume":"39","author":"Ramirez","year":"2004","journal-title":"Genesis"},{"key":"2021042608430353500_DEV128553C50","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1093\/hmg\/ddt029","article-title":"The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice","volume":"22","author":"Reichmann","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"2021042608430353500_DEV128553C51","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1093\/nar\/gkn083","article-title":"Bisulfite sequencing Data Presentation and Compilation (BDPC) web server--a useful tool for DNA methylation analysis","volume":"36","author":"Rohde","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2021042608430353500_DEV128553C52","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"Rossant","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"2021042608430353500_DEV128553C53","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/sj.embor.embor939","article-title":"An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development","volume":"4","author":"Saba-El-Leil","year":"2003","journal-title":"EMBO Rep."},{"key":"2021042608430353500_DEV128553C65","doi-asserted-by":"publisher","first-page":"e71113","DOI":"10.1371\/journal.pone.0071113","article-title":"Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice","volume":"8","author":"Schemmer","year":"2013","journal-title":"PLoS One"},{"key":"2021042608430353500_DEV128553C54","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.ydbio.2007.01.009","article-title":"Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta","volume":"304","author":"Simmons","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042608430353500_DEV128553C55","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1097\/SLA.0b013e3182a6f552","article-title":"Distinct pathways regulated by RET and estrogen receptor in luminal breast cancer demonstrate the biological basis for combination therapy","volume":"259","author":"Spanheimer","year":"2014","journal-title":"Ann. Surg."},{"key":"2021042608430353500_DEV128553C56","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1093\/molehr\/6.11.1019","article-title":"p57(Kip2) regulates the proper development of labyrinthine and spongiotrophoblasts","volume":"6","author":"Takahashi","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"2021042608430353500_DEV128553C57","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1006\/dbio.1997.8685","article-title":"Mash2 acts cell autonomously in mouse spongiotrophoblast development","volume":"190","author":"Tanaka","year":"1997","journal-title":"Dev. Biol."},{"key":"2021042608430353500_DEV128553C58","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1128\/MCB.22.9.3149-3156.2002","article-title":"Transcription factor gene AP-2 gamma essential for early murine development","volume":"22","author":"Werling","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2021042608430353500_DEV128553C59","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0143-4004(88)90002-1","article-title":"Human choriocarcinoma (JAr) cells grown as multicellular spheroids","volume":"9","author":"White","year":"1988","journal-title":"Placenta"},{"key":"2021042608430353500_DEV128553C60","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1530\/rep.1.00869","article-title":"Mouse pregnancy-specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature","volume":"131","author":"Wynne","year":"2006","journal-title":"Reproduction"},{"key":"2021042608430353500_DEV128553C61","doi-asserted-by":"publisher","first-page":"32124","DOI":"10.1074\/jbc.M302847200","article-title":"Protein kinase B alpha\/Akt1 regulates placental development and fetal growth","volume":"278","author":"Yang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021042608430353500_DEV128553C62","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/0143-4004(77)90002-9","article-title":"Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta","volume":"18","author":"Zhou","year":"1997","journal-title":"Placenta"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.128553","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/143\/5\/787\/1845712\/dev128553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.128553\/2034131\/dev_128553v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.128553\/2034131\/dev_128553v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T16:52:16Z","timestamp":1621356736000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/doi\/10.1242\/dev.128553\/256802\/Tpbpa-mediated-deletion-of-Tfap2c-leads-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":63,"URL":"https:\/\/doi.org\/10.1242\/dev.128553","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]},"article-number":"dev.128553"}}