{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:52:17Z","timestamp":1790157137497,"version":"4.0.1"},"reference-count":88,"publisher":"The Company of Biologists","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:p>The members of the AP-2 family of transcription factors play important roles during mammalian development and morphogenesis. AP-2\u03b3 (Tcfap2c \u2013 Mouse Genome Informatics) is a retinoic acid-responsive gene implicated in placental development and the progression of human breast cancer. We show that AP-2\u03b3 is present in all cells of preimplantation embryos and becomes restricted to the extra-embryonic lineages at the time of implantation. To study further the biological function of AP-2\u03b3, we have generated Tcfap2c-deficient mice by gene disruption. The majority of Tcfap2c\u2013\/\u2013 mice failed to survive beyond 8.5 days post coitum (d.p.c.). At 7.5 d.p.c., Tcfap2c\u2013\/\u2013 mutants were typically arrested or retarded in their embryonic development in comparison to controls. Morphological and molecular analyses of mutants revealed that gastrulation could be initiated and that anterior-posterior patterning of the epiblast remained intact. However, the Tcfap2c mutants failed to establish a normal maternal-embryonic interface, and the extra-embryonic tissues were malformed. Moreover, the trophoblast-specific expression of eomesodermin and Cdx2, two genes implicated in FGF-responsive trophoblast stem cell maintenance, was significantly reduced. Chimera studies demonstrated that AP-2\u03b3 plays no major autonomous role in the development of the embryo proper. By contrast, the presence of AP-2\u03b3 in the extra-embryonic membranes is required for normal development of this compartment and also for survival of the mouse embryo.<\/jats:p>","DOI":"10.1242\/dev.129.11.2733","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T04:52:02Z","timestamp":1619412722000},"page":"2733-2747","source":"Crossref","is-referenced-by-count":202,"title":["Transcription factor AP-2\u03b3 is essential in the extra-embryonic lineages for early postimplantation development"],"prefix":"10.1242","volume":"129","author":[{"given":"Heidi J.","family":"Auman","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Nottoli","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA"},{"name":"Present address: Gene Targeting Service, Section of Comparative Medicine, Yale University School of Medicine, PO Box 208016, New Haven, CT 06520-8016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Lakiza","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA"},{"name":"Present address: Northwestern University Medical School, Children\u2019s Memorial Hospital, 2300 Children\u2019s Plaza, MC 204, Chicago, IL 60614, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinton","family":"Winger","sequence":"additional","affiliation":[{"name":"Departments of Craniofacial Biology, and Cellular and Structural Biology, BRB151, Campus Box C286, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, USA"},{"name":"Departments of Craniofacial Biology, and Cellular and Structural Biology, BRB151, Campus Box C286, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042604171379500_ARMAN-ETAL-1998","doi-asserted-by":"crossref","unstructured":"Arman, E., Haffner-Krausz, R., Chen, Y., Heath, J. 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