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However, the unavailability of a mouse model, and the difficulties in studying cellular and axonal migration in vertebrates have hampered an understanding of its function. We have identified the C. elegans homolog, kal-1, and document its function in vivo. We show that kal-1 is part of a mechanism by which neurons influence migration and adhesion of epidermal cells undergoing morphogenesis during ventral enclosure and male tail formation. We also show that kal-1 affects neurite outgrowth in vivo by modulating branching. Finally, we find that human KAL-1 cDNA can compensate for the loss of worm kal-1 and that overexpression of worm or human KAL-1 cDNAs in the nematode results in the same phenotypes. These data indicate functional conservation between the human and nematode proteins and establish C. elegans as a powerful animal in which to investigate KAL function in vivo. Our findings add a new player to the set of molecules, which appear to underlie both morphogenesis and axonal\/neuronal navigation in vertebrates and invertebrates.<\/jats:p>","DOI":"10.1242\/dev.129.5.1283","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T14:24:50Z","timestamp":1619360690000},"page":"1283-1294","source":"Crossref","is-referenced-by-count":77,"title":["The Kallmann syndrome gene homolog in<i>C. elegans<\/i>is involved in epidermal morphogenesis and neurite branching"],"prefix":"10.1242","volume":"129","author":[{"given":"Elena I.","family":"Rugarli","sequence":"first","affiliation":[{"name":"Telethon Institute of Genetics and Medicine (TIGEM), via P. Castellino III, 80131 Naples, ltaly"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Di Schiavi","sequence":"additional","affiliation":[{"name":"International Institute of Genetics and Biophysics (IIGB), via P. 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