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The paucity of small IHBD was linked to a failure in the organization of duct structures during liver organogenesis, suggesting an essential function of Hnf1b in bile duct morphogenesis. Mutant mice also lacked interlobular arteries. As HNF1\u03b2 is not expressed in these cells, it further emphasizes the link between arterial and biliary formation. Hepatocyte metabolism was also affected and we identified hepatocyte-specific HNF1\u03b2 target genes involved in bile acids sensing and in fatty acid oxidation.<\/jats:p>","DOI":"10.1242\/dev.129.8.1829","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T20:29:04Z","timestamp":1619209744000},"page":"1829-1838","source":"Crossref","is-referenced-by-count":314,"title":["Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1\u03b2"],"prefix":"10.1242","volume":"129","author":[{"given":"Catherine","family":"Coffinier","sequence":"first","affiliation":[{"name":"Unite\u0301 des Virus Oncoge\u0300nes-CNRS URA 1644, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France"},{"name":"Present address: Howard Hughes Medical Institute-UCLA, Los Angeles, CA 90095-1662, USA"},{"name":"Both authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Gresh","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Virus Oncoge\u0300nes-CNRS URA 1644, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France"},{"name":"Both authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Fiette","sequence":"additional","affiliation":[{"name":"Unite\u0301 d\u2019Expertise en Histotechnologie et Pathologie, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois","family":"Tronche","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany"},{"name":"Present address: Institut de Biologie, CNRS FRE 2401, Colle\u0300ge de France, 11, place Marcelin Berthelot, 75231 Paris Cedex 5, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u0308nther","family":"Schu\u0308tz","sequence":"additional","affiliation":[{"name":"Division Molecular Biology of the Cell I, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Babinet","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie du De\u0301veloppement-CNRS URA 1960, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pontoglio","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Virus Oncoge\u0300nes-CNRS URA 1644, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Yaniv","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Virus Oncoge\u0300nes-CNRS URA 1644, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Barra","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie du De\u0301veloppement-CNRS URA 1960, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042512503662900_BARBACCI-ETAL-1999","doi-asserted-by":"crossref","unstructured":"Barbacci, E., Reber, M., Ott, M. 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