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By taking advantage of the invariant cell lineage of C. elegans, we used an intestinal-specific GFP reporter in a screen to identify mutants that undergo cell division abnormalities in the intestinal lineage. We have isolated a mutant with twice the wild-type complement of intestinal cells, all of which arise during mid-embryogenesis. This mutant, called rr31, is a fully dominant, maternal-effect, gain-of-function mutation in the cdc-25.1 cell cycle phosphatase that sensitizes the intestinal lineage to an extra cell division. We showed that cdc-25.1 acts at the G1\/S transition, as ectopic expression of CDC-25.1 caused entry into S phase in intestinal cells. In addition, we showed that the cdc-25.1(gf) requires cyclin E. The extra cell division defect was shown to be restricted to the E lineage and the E fate is necessary and sufficient to sensitize cells to this mutation.<\/jats:p>","DOI":"10.1242\/dev.129.9.2155","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T05:06:27Z","timestamp":1619413587000},"page":"2155-2165","source":"Crossref","is-referenced-by-count":50,"title":["Organ-specific cell division abnormalities caused by mutation in a general cell cycle regulator in<i>C. elegans<\/i>"],"prefix":"10.1242","volume":"129","author":[{"given":"Ivana","family":"Kostic\u0301","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042604261723500_AMBROS-1999","doi-asserted-by":"crossref","unstructured":"Ambros, V. 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