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Re-epithelialization of partial- or full-thickness skin wounds of adult zebrafish, however, is extremely rapid and largely independent of the other processes of wound healing. Live imaging after treatment with transgene-encoded or chemical inhibitors reveals that re-epithelializing keratinocytes repopulate wounds by TGF\u03b2- and integrin-dependent lamellipodial crawling at the leading edges of the epidermal tongue. In addition, re-epithelialization requires long-range Rho kinase-, JNK- and, to some extent, planar cell polarity-dependent epithelial rearrangements within the following epidermis, involving radial intercalations, flattening and directed elongations of cells. These rearrangements lead to a massive recruitment of keratinocytes from the adjacent epidermis and make re-epithelialization independent of keratinocyte proliferation and the mitogenic effect of FGF signalling, which are only required after wound closure, allowing the epidermis outside the wound to re-establish its normal thickness. Together these results demonstrate that the adult zebrafish is a valuable in-vivo model for studying, and visualizing, the processes involved in cutaneous wound closure, facilitating the dissection of direct from indirect, and motogenic from mitogenic effects of genes and molecules affecting wound re-epithelialization.<\/jats:p>","DOI":"10.1242\/dev.130492","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T16:33:53Z","timestamp":1461861233000},"source":"Crossref","is-referenced-by-count":72,"title":["Re-epithelialization of cutaneous wounds in adult zebrafish uses a combination of mechanisms at play during wound closure in embryonic and adult mammals"],"prefix":"10.1242","author":[{"given":"Rebecca","family":"Richardson","sequence":"first","affiliation":[{"name":"Institute of Developmental Biology, University of Cologne, D-50674 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Metzger","sequence":"additional","affiliation":[{"name":"Institute of Developmental Biology, University of Cologne, D-50674 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Knyphausen","sequence":"additional","affiliation":[{"name":"Institute of Developmental Biology, University of Cologne, D-50674 Cologne, Germany"},{"name":"Graduate School for Biological Sciences, University of Cologne, D-50674 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ramezani","sequence":"additional","affiliation":[{"name":"Institute of Developmental Biology, University of Cologne, D-50674 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krasimir","family":"Slanchev","sequence":"additional","affiliation":[{"name":"Georges-Koehler Laboratory, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kraus","sequence":"additional","affiliation":[{"name":"Institute of Developmental Biology, University of Cologne, D-50674 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmon","family":"Schmelzer","sequence":"additional","affiliation":[{"name":"Cell Biology, Max-Planck Institute for Plant Breeding Research, D-50829 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3709-8166","authenticated-orcid":false,"given":"Matthias","family":"Hammerschmidt","sequence":"additional","affiliation":[{"name":"Institute of Developmental Biology, University of Cologne, D-50674 Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne, University of Cologne, D-50931 Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, D-50931 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608263123000_DEV130492C1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.cub.2013.11.048","article-title":"Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair","volume":"24","author":"Abreu-Blanco","year":"2014","journal-title":"Curr. 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