{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:30:04Z","timestamp":1763551804083,"version":"3.41.2"},"reference-count":32,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":1964,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD054534"],"award-info":[{"award-number":["HD054534"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["EY024354"],"award-info":[{"award-number":["EY024354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>The zebrafish pineal complex consists of four cell types (rod and cone photoreceptors, projection neurons, and parapineal neurons) that are derived from a single pineal complex anlage. After specification, parapineal neurons migrate unilaterally away from the rest of the pineal complex while rods, cones, and projection neurons are non-migratory. The transcription factor Tbx2b is important for both the correct number and migration of parapineal neurons. We find that two additional transcription factors, Flh and Nr2e3, negatively regulate parapineal formation. Flh induces non-migratory neuron fates and limits the extent of parapineal specification, in part by activation of Nr2e3 expression. Tbx2b is positively regulated by Flh, but opposes Flh action during specification of parapineal neurons. Loss of parapineal neuron specification in Tbx2b-deficient embryos can be partially rescued via loss of Nr2e3 or Flh function; however, parapineal migration absolutely requires Tbx2b activity. We conclude that cell specification and migration in the pineal complex are regulated by a network of at least three transcription factors.<\/jats:p>","DOI":"10.1242\/dev.131680","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T01:58:54Z","timestamp":1466215134000},"source":"Crossref","is-referenced-by-count":4,"title":["A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex"],"prefix":"10.1242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4888-4768","authenticated-orcid":false,"given":"Sataree","family":"Khuansuwan","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Clanton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Dean","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-0870","authenticated-orcid":false,"given":"James G.","family":"Patton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua T.","family":"Gamse","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042608355908900_DEV131680C1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1073\/pnas.0809439106","article-title":"Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development","volume":"106","author":"Alvarez-Delfin","year":"2009","journal-title":"Proc. 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