{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:41:18Z","timestamp":1790505678465,"version":"4.1.0"},"reference-count":78,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":335,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:p>While the genetic interactions between signaling pathways and transcription factors have been largely decoded, much remains to be learned about the epigenetic regulation of cerebellar development. Here, we report that cerebellar deletion of Ezh2, the methyltransferase subunit of the PRC2 complex, results in reduced H3K27me3 and profound transcriptional dysregulation, including that of a set of transcription factors directly involved in cerebellar neuronal cell type specification and differentiation. Such transcriptional changes led to increased GABAergic interneurons and decreased.Purkinje cells. Transcriptional changes also inhibited the proliferation of granule precursor cells derived from the rhombic lip. The loss of both cell types ultimately resulted in cerebellar hypoplasia. These findings indicate Ezh2\/PRC2 plays critical roles in regulating neurogenesis from both cerebellar germinal zones.<\/jats:p>","DOI":"10.1242\/dev.132902","type":"journal-article","created":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T02:00:01Z","timestamp":1460426401000},"source":"Crossref","is-referenced-by-count":29,"title":["Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum"],"prefix":"10.1242","author":[{"given":"Xuesong","family":"Feng","sequence":"first","affiliation":[{"name":"Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, 50 South Drive, Bethesda MD, 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aster H.","family":"Juan","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, 50 South Drive, Bethesda MD, 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, 50 South Drive, Bethesda MD, 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Dae","family":"Ko","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, 50 South Drive, Bethesda MD, 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Zare","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, 50 South Drive, Bethesda MD, 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-3675","authenticated-orcid":false,"given":"Vittorio","family":"Sartorelli","sequence":"additional","affiliation":[{"name":"Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, 50 South Drive, Bethesda MD, 20892 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608342967700_DEV132902C1","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1523\/JNEUROSCI.23-12-05105.2003","article-title":"Factors in the genetic background suppress the engrailed-1 cerebellar phenotype","volume":"23","author":"Bilovocky","year":"2003","journal-title":"J. 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