{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:59:57Z","timestamp":1793260797639,"version":"4.5.0"},"reference-count":155,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F30 HL126487"],"award-info":[{"award-number":["F30 HL126487"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 GM007171"],"award-info":[{"award-number":["T32 GM007171"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL081674"],"award-info":[{"award-number":["R01 HL081674"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL131319"],"award-info":[{"award-number":["R01 HL131319"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["1-FY14-205"],"award-info":[{"award-number":["1-FY14-205"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:p>The adult human heart does not regenerate significant amounts of lost tissue after injury. Rather than making new, functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal arrhythmias and heart failure. The most-cited basis of this ineffective cardiac regeneration in mammals is the low proliferative capacity of adult cardiomyocytes. However, mammalian cardiomyocytes can avidly proliferate during fetal and neonatal development, and both adult zebrafish and neonatal mice can regenerate cardiac muscle after injury, suggesting that latent regenerative potential exists. Dissecting the cellular and molecular mechanisms that promote cardiomyocyte proliferation throughout life, deciphering why proliferative capacity normally dissipates in adult mammals, and deriving means to boost this capacity are primary goals in cardiovascular research. Here, we review our current understanding of how cardiomyocyte proliferation is regulated during heart development and regeneration.<\/jats:p>","DOI":"10.1242\/dev.132910","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T07:53:21Z","timestamp":1456818801000},"page":"729-740","source":"Crossref","is-referenced-by-count":236,"title":["Building and re-building the heart by cardiomyocyte proliferation"],"prefix":"10.1242","volume":"143","author":[{"given":"Matthew J.","family":"Foglia","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Poss","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608444476700_DEV132910C1","doi-asserted-by":"publisher","first-page":"8850","DOI":"10.1073\/pnas.1408233111","article-title":"Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice","volume":"111","author":"Ali","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C2","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.cell.2015.10.035","article-title":"No evidence for cardiomyocyte number expansion in preadolescent mice","volume":"163","author":"Alkass","year":"2015","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C3","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1172\/JCI72181","article-title":"Macrophages are required for neonatal heart regeneration","volume":"124","author":"Aurora","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2021042608444476700_DEV132910C4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/jmor.1051550307","article-title":"Repair and reorganization of minced cardiac muscle in the adult newt (Notophthalmus viridescens)","volume":"155","author":"Bader","year":"1978","journal-title":"J. Morphol."},{"key":"2021042608444476700_DEV132910C5","doi-asserted-by":"publisher","first-page":"5863","DOI":"10.1038\/ncomms6863","article-title":"Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction","volume":"5","author":"B\u00e4r","year":"2014","journal-title":"Nat. Commun."},{"key":"2021042608444476700_DEV132910C6","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1016\/j.celrep.2015.07.064","article-title":"Telomerase is essential for zebrafish heart regeneration","volume":"12","author":"Bednarek","year":"2015","journal-title":"Cell Rep."},{"key":"2021042608444476700_DEV132910C7","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nrcardio.2014.9","article-title":"Cell therapy for cardiac repair\u2014lessons from clinical trials","volume":"11","author":"Behfar","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"2021042608444476700_DEV132910C8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S0092-8674(03)00687-1","article-title":"Adult cardiac stem cells are multipotent and support myocardial regeneration","volume":"114","author":"Beltrami","year":"2003","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C9","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"2021042608444476700_DEV132910C10","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","article-title":"Dynamics of cell generation and turnover in the human heart","volume":"161","author":"Bergmann","year":"2015","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C11","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","article-title":"Neuregulin1\/ErbB4 signaling Induces cardiomyocyte proliferation and repair of heart Injury","volume":"138","author":"Bersell","year":"2009","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C12","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1242\/jcs.00698","article-title":"Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes","volume":"116","author":"Bettencourt-Dias","year":"2003","journal-title":"J. Cell Sci."},{"key":"2021042608444476700_DEV132910C13","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.ydbio.2006.12.012","article-title":"Why polyps regenerate and we don't: Towards a cellular and molecular framework for Hydra regeneration","volume":"303","author":"Bosch","year":"2007","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1242\/dev.054239","article-title":"Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2","volume":"138","author":"Brade","year":"2011","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C15","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1146\/annurev.cellbio.24.110707.175336","article-title":"Comparative aspects of animal regeneration","volume":"24","author":"Brockes","year":"2008","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2021042608444476700_DEV132910C16","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/BF00190566","article-title":"Polyploidy in cardiac myocytes of normal and hypertrophic human hearts; range of values","volume":"424","author":"Brodsky","year":"1994","journal-title":"Virchows Arch."},{"key":"2021042608444476700_DEV132910C17","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nrg1710","article-title":"Building the mammalian heart from two sources of myocardial cells","volume":"6","author":"Buckingham","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"2021042608444476700_DEV132910C18","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1242\/jcs.03386","article-title":"Stimulation of ES-cell-derived cardiomyogenesis and neonatal cardiac cell proliferation by reactive oxygen species and NADPH oxidase","volume":"120","author":"Buggisch","year":"2007","journal-title":"J. Cell Sci."},{"key":"2021042608444476700_DEV132910C19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-213X-11-21","article-title":"The zebrafish heart regenerates after cryoinjury-induced myocardial infarction","volume":"11","author":"Chablais","year":"2011","journal-title":"BMC Dev. Biol."},{"key":"2021042608444476700_DEV132910C20","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0040-8166(74)90037-8","article-title":"The architectural development of the early mammalian heart","volume":"6","author":"Challice","year":"1974","journal-title":"Tissue Cell"},{"key":"2021042608444476700_DEV132910C21","doi-asserted-by":"publisher","first-page":"35858","DOI":"10.1074\/jbc.M404975200","article-title":"Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium","volume":"279","author":"Chaudhry","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021042608444476700_DEV132910C22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1006\/dbio.2002.0796","article-title":"Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor","volume":"250","author":"Chen","year":"2002","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C23","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1242\/dev.01094","article-title":"BMP10 is essential for maintaining cardiac growth during murine cardiogenesis","volume":"131","author":"Chen","year":"2004","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1161\/CIRCRESAHA.112.270264","article-title":"Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5","volume":"111","author":"Chen","year":"2012","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C25","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1242\/dev.089920","article-title":"Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity","volume":"140","author":"Chen","year":"2013","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C26","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1006\/dbio.2000.9753","article-title":"Chamber formation and morphogenesis in the developing mammalian heart","volume":"223","author":"Christoffels","year":"2000","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C27","first-page":"H55","article-title":"Effect of increased pressure on ventricular growth in stage 21 chick embryos","volume":"257","author":"Clark","year":"1989","journal-title":"Am. J. Physiol."},{"key":"2021042608444476700_DEV132910C28","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1242\/dev.030924","article-title":"Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart","volume":"136","author":"de Pater","year":"2009","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C29","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.devcel.2008.09.005","article-title":"Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development","volume":"15","author":"Drenckhahn","year":"2008","journal-title":"Dev. Cell"},{"key":"2021042608444476700_DEV132910C30","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/ncb3149","article-title":"ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation","volume":"17","author":"D'Uva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"2021042608444476700_DEV132910C166","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.cell.2013.07.039","article-title":"Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair","volume":"154","author":"Ellison","year":"2013","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C31","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1101\/gad.1306705","article-title":"p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes","volume":"19","author":"Engel","year":"2005","journal-title":"Genes Dev."},{"key":"2021042608444476700_DEV132910C167","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature11739","article-title":"Functional screening identifies miRNAs inducing cardiac regeneration","volume":"492","author":"Eulalio","year":"2012","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C32","doi-asserted-by":"publisher","first-page":"13416","DOI":"10.1073\/pnas.1309810110","article-title":"Translational profiling of cardiomyocytes identifies an early Jak1\/Stat3 injury response required for zebrafish heart regeneration","volume":"110","author":"Fang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C33","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s00429-002-0249-6","article-title":"Cell cycle reentry of ventricular and atrial cardiomyocytes and cells within the epicardium following amputation of the ventricular apex in the axolotl, Amblystoma mexicanum: confocal microscopic immunofluorescent image analysis of bromodeoxyuridine-labeled nuclei","volume":"205","author":"Flink","year":"2002","journal-title":"Anat. Embryol."},{"key":"2021042608444476700_DEV132910C34","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1006\/jmcc.1997.0620","article-title":"Changes in E2F complexes containing retinoblastoma protein family members and increased cyclin-dependent kinase inhibitor activities during terminal differentiation of cardiomyocytes","volume":"30","author":"Flink","year":"1998","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021042608444476700_DEV132910C35","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1046\/j.1432-0436.2002.690412.x","article-title":"Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again","volume":"69","author":"Forsyth","year":"2002","journal-title":"Differentiation"},{"key":"2021042608444476700_DEV132910C37","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/378390a0","article-title":"Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor","volume":"378","author":"Gassmann","year":"1995","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C38","doi-asserted-by":"publisher","first-page":"e05871","DOI":"10.7554\/eLife.05871","article-title":"Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish","volume":"4","author":"Gemberling","year":"2015","journal-title":"eLife"},{"key":"2021042608444476700_DEV132910C39","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.jacc.2011.07.054","article-title":"An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials","volume":"59","author":"Gerczuk","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021042608444476700_DEV132910C40","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S1097-2765(00)80342-1","article-title":"Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development","volume":"4","author":"Gerety","year":"1999","journal-title":"Mol. Cell"},{"key":"2021042608444476700_DEV132910C41","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.yjmcc.2015.09.017","article-title":"Harnessing the microRNA pathway for cardiac regeneration","volume":"89A","author":"Giacca","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021042608444476700_DEV132910C168","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"103","author":"Gnecchi","year":"2008","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C42","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1242\/dev.060897","article-title":"Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish","volume":"138","author":"Gonz\u00e1lez-Rosa","year":"2011","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C43","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ydbio.2012.07.007","article-title":"Pan-epicardial lineage tracing reveals that epicardium derived cells give rise to myofibroblasts and perivascular cells during zebrafish heart regeneration","volume":"370","author":"Gonz\u00e1lez-Rosa","year":"2012","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C44","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.devcel.2006.12.011","article-title":"Notch signaling is essential for ventricular chamber development","volume":"12","author":"Grego-Bessa","year":"2007","journal-title":"Dev. Cell"},{"key":"2021042608444476700_DEV132910C45","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.devcel.2015.04.021","article-title":"HIF1\u03b1 represses cell stress pathways to allow proliferation of hypoxic fetal cardiomyocytes","volume":"33","author":"Guimar\u00e3es-Camboa","year":"2015","journal-title":"Dev. Cell"},{"key":"2021042608444476700_DEV132910C46","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nature11045","article-title":"Clonally dominant cardiomyocytes direct heart morphogenesis","volume":"484","author":"Gupta","year":"2012","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C47","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.cub.2013.05.028","article-title":"An injury-responsive gata4 program shapes the zebrafish cardiac ventricle","volume":"23","author":"Gupta","year":"2013","journal-title":"Curr. Biol."},{"key":"2021042608444476700_DEV132910C48","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/cr.2014.108","article-title":"Hydrogen peroxide primes heart regeneration with a derepression mechanism","volume":"24","author":"Han","year":"2014","journal-title":"Cell Res."},{"key":"2021042608444476700_DEV132910C49","doi-asserted-by":"crossref","first-page":"966","DOI":"10.18632\/aging.100526","article-title":"Complete cardiac regeneration in a mouse model of myocardial infarction","volume":"4","author":"Haubner","year":"2012","journal-title":"Aging"},{"key":"2021042608444476700_DEV132910C50","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size","volume":"332","author":"Heallen","year":"2011","journal-title":"Science"},{"key":"2021042608444476700_DEV132910C51","doi-asserted-by":"publisher","first-page":"4683","DOI":"10.1242\/dev.102798","article-title":"Hippo signaling impedes adult heart regeneration","volume":"140","author":"Heallen","year":"2013","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C52","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1161\/CIRCRESAHA.115.307697","article-title":"Tissue-specific cell cycle indicator reveals unexpected findings for cardiac myocyte proliferation","volume":"118","author":"Hirai","year":"2015","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C53","doi-asserted-by":"publisher","first-page":"e96725","DOI":"10.1371\/journal.pone.0096725","article-title":"c-kit+ cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart","volume":"9","author":"Hong","year":"2014","journal-title":"PLoS ONE"},{"key":"2021042608444476700_DEV132910C54","doi-asserted-by":"publisher","first-page":"e67266","DOI":"10.1371\/journal.pone.0067266","article-title":"Igf signaling is required for cardiomyocyte proliferation during zebrafish heart development and regeneration","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042608444476700_DEV132910C55","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C56","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/dvdy.24154","article-title":"Differential reparative phenotypes between zebrafish and medaka after cardiac injury","volume":"243","author":"Ito","year":"2014","journal-title":"Dev. Dyn."},{"key":"2021042608444476700_DEV132910C57","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2021042608444476700_DEV132910C58","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C59","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1161\/CIRCULATIONAHA.112.107888","article-title":"Hypoxia induces myocardial regeneration in zebrafish","volume":"126","author":"Jopling","year":"2012","journal-title":"Circulation"},{"key":"2021042608444476700_DEV132910C60","doi-asserted-by":"publisher","first-page":"13255","DOI":"10.1073\/pnas.1511209112","article-title":"Myocardial NF-\u03baB activation is essential for zebrafish heart regeneration","volume":"112","author":"Karra","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C61","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/S1534-5807(01)00040-5","article-title":"The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm","volume":"1","author":"Kelly","year":"2001","journal-title":"Dev. Cell"},{"key":"2021042608444476700_DEV132910C62","doi-asserted-by":"publisher","first-page":"a015750","DOI":"10.1101\/cshperspect.a015750","article-title":"Heart fields and cardiac morphogenesis","volume":"4","author":"Kelly","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"2021042608444476700_DEV132910C63","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/nature08804","article-title":"Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes","volume":"464","author":"Kikuchi","year":"2010","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C64","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1242\/dev.067041","article-title":"tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration","volume":"138","author":"Kikuchi","year":"2011","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C65","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.devcel.2011.01.010","article-title":"Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration","volume":"20","author":"Kikuchi","year":"2011","journal-title":"Dev. Cell"},{"key":"2021042608444476700_DEV132910C66","doi-asserted-by":"publisher","first-page":"17206","DOI":"10.1073\/pnas.0915016107","article-title":"PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts","volume":"107","author":"Kim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C67","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature14582","article-title":"Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart","volume":"523","author":"Kimura","year":"2015","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C68","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/0092-8674(93)90515-R","article-title":"WT-1 is required for early kidney development","volume":"74","author":"Kreidberg","year":"1993","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C69","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev."},{"key":"2021042608444476700_DEV132910C70","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/nature10147","article-title":"Heart regeneration","volume":"473","author":"Laflamme","year":"2011","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C71","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/ar.21492","article-title":"The Giant Danio (D. aequipinnatus) as a model of cardiac remodeling and regeneration","volume":"295","author":"Lafontant","year":"2012","journal-title":"Anat. Rec."},{"key":"2021042608444476700_DEV132910C169","doi-asserted-by":"publisher","first-page":"16029","DOI":"10.1073\/pnas.1406508111","article-title":"Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart","volume":"111","author":"Lavine","year":"2014","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C72","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/378394a0","article-title":"Requirement for neuregulin receptor erbB2 in neural and cardiac development","volume":"378","author":"Lee","year":"1995","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C73","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.cell.2006.08.052","article-title":"A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration","volume":"127","author":"Lepilina","year":"2006","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C74","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1006\/jmcc.1996.0163","article-title":"Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development","volume":"28","author":"Li","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021042608444476700_DEV132910C75","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1006\/jmcc.1997.0381","article-title":"Formation of binucleated cardiac myocytes in rat heart: I. Role of actin\u2013myosin contractile ring","volume":"29","author":"Li","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021042608444476700_DEV132910C76","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1242\/dev.054338","article-title":"IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development","volume":"138","author":"Li","year":"2011","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C77","doi-asserted-by":"publisher","first-page":"e260","DOI":"10.1371\/journal.pbio.0040260","article-title":"Gene expression analysis of zebrafish heart regeneration","volume":"4","author":"Lien","year":"2006","journal-title":"PLoS Biol."},{"key":"2021042608444476700_DEV132910C78","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C79","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.1242\/dev.053736","article-title":"A dual role for ErbB2 signaling in cardiac trabeculation","volume":"137","author":"Liu","year":"2010","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C80","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature06293","article-title":"Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system","volume":"450","author":"Livet","year":"2007","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C82","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nature12054","article-title":"Meis1 regulates postnatal cardiomyocyte cell cycle arrest","volume":"497","author":"Mahmoud","year":"2013","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C83","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.devcel.2015.06.017","article-title":"Nerves regulate cardiomyocyte proliferation and heart regeneration","volume":"34","author":"Mahmoud","year":"2015","journal-title":"Dev. Cell"},{"key":"2021042608444476700_DEV132910C84","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.scr.2014.04.007","article-title":"The epicardium signals the way towards heart regeneration","volume":"13","author":"Masters","year":"2014","journal-title":"Stem Cell Res."},{"key":"2021042608444476700_DEV132910C85","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/(SICI)1097-0185(199806)251:2&lt;245::AID-AR14&gt;3.0.CO;2-O","article-title":"Comparison of mitosis in binucleated and mononucleated newt cardiac myocytes","volume":"251","author":"Matz","year":"1998","journal-title":"Anat. Rec."},{"key":"2021042608444476700_DEV132910C86","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/eurjhf\/hfs105","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012","volume":"14","author":"McMurray","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"2021042608444476700_DEV132910C87","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1242\/dev.00580","article-title":"A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart","volume":"130","author":"Meilhac","year":"2003","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C88","doi-asserted-by":"publisher","first-page":"18455","DOI":"10.1073\/pnas.0504343102","article-title":"Epicardial retinoid X receptor \u03b1 is required for myocardial growth and coronary artery formation","volume":"102","author":"Merki","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C89","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/378386a0","article-title":"Multiple essential functions of neuregulin in development","volume":"378","author":"Meyer","year":"1995","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C90","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/aja.1001930104","article-title":"Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus: I. Formation of the ventricular myocardium","volume":"193","author":"Mikawa","year":"1992","journal-title":"Dev. Dyn."},{"key":"2021042608444476700_DEV132910C91","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/aja.1001950208","article-title":"Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus. III: Polyclonal origin of adjacent ventricular myocytes","volume":"195","author":"Mikawa","year":"1992","journal-title":"Dev. Dyn."},{"key":"2021042608444476700_DEV132910C92","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/dbio.2001.0409","article-title":"The outflow tract of the heart Is recruited from a novel heart-forming field","volume":"238","author":"Mjaatvedt","year":"2001","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C93","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","article-title":"Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis","volume":"11","author":"Molkentin","year":"1997","journal-title":"Genes Dev."},{"key":"2021042608444476700_DEV132910C94","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1073\/pnas.1214608110","article-title":"Cardiomyocyte proliferation contributes to heart growth in young humans","volume":"110","author":"Mollova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C95","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.yjmcc.2014.10.017","article-title":"Redox regulation of cardiomyocyte cell cycling via an ERK1\/2 and c-Myc-dependent activation of cyclin D2 transcription","volume":"79","author":"Murray","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021042608444476700_DEV132910C96","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2014.03.035","article-title":"A proliferative burst during preadolescence establishes the final cardiomyocyte number","volume":"157","author":"Naqvi","year":"2014","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C97","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2015.10.038","article-title":"Cardiomyocytes replicate and their numbers increase in young hearts","volume":"163","author":"Naqvi","year":"2015","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C98","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/jez.1401870208","article-title":"Response of the adult newt ventricle to injury","volume":"187","author":"Oberpriller","year":"1974","journal-title":"J. Exp. Zool."},{"key":"2021042608444476700_DEV132910C99","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1006\/jmcc.1996.0137","article-title":"Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart","volume":"28","author":"Olivetti","year":"1996","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021042608444476700_DEV132910C100","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1161\/CIRCRESAHA.116.302752","article-title":"Molecular regulation of cardiomyocyte differentiation","volume":"116","author":"Paige","year":"2015","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C101","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1161\/01.RES.0000152326.91223.4F","article-title":"Targeted expression of Cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice","volume":"96","author":"Pasumarthi","year":"2005","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C102","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/dvdy.10360","article-title":"Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart","volume":"228","author":"Pennisi","year":"2003","journal-title":"Dev. Dyn."},{"key":"2021042608444476700_DEV132910C103","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1006\/dbio.2002.0706","article-title":"Experimental studies on the spatiotemporal expression of WT1 and RALDH2 in the embryonic avian heart: a model for the regulation of myocardial and valvuloseptal development by epicardially derived cells (EPDCs)","volume":"247","author":"P\u00e9rez-Pomares","year":"2002","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C104","doi-asserted-by":"publisher","first-page":"281ra45","DOI":"10.1126\/scitranslmed.aaa5171","article-title":"Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window","volume":"7","author":"Polizzotti","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"2021042608444476700_DEV132910C105","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1006\/jmcc.1998.0808","article-title":"Expressions and activities of cell cycle regulatory molecules during the transition from myocyte hyperplasia to hypertrophy","volume":"30","author":"Poolman","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2021042608444476700_DEV132910C106","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"2021042608444476700_DEV132910C107","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C108","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/nrg287","article-title":"Advances in understanding tissue regenerative capacity and mechanisms in animals","volume":"11","author":"Poss","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"2021042608444476700_DEV132910C109","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"2021042608444476700_DEV132910C110","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C111","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C112","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.ydbio.2008.02.044","article-title":"ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish","volume":"317","author":"Qu","year":"2008","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C113","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1146\/annurev.cellbio.20.010403.095114","article-title":"Fundamentals of planarian regeneration","volume":"20","author":"Reddien","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2021042608444476700_DEV132910C114","doi-asserted-by":"publisher","first-page":"e115871","DOI":"10.1371\/journal.pone.0115871","article-title":"Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice","volume":"9","author":"Reuter","year":"2014","journal-title":"PLoS ONE"},{"key":"2021042608444476700_DEV132910C115","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1161\/CIRCRESAHA.116.305374","article-title":"Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications","volume":"116","author":"Sadahiro","year":"2015","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C116","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/S0039-6060(97)90034-9","article-title":"Hemodynamic alteration by fetal surgery accelerates myocyte proliferation in fetal guinea pig hearts","volume":"122","author":"Saiki","year":"1997","journal-title":"Surgery"},{"key":"2021042608444476700_DEV132910C117","doi-asserted-by":"publisher","first-page":"e18503","DOI":"10.1371\/journal.pone.0018503","article-title":"Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation","volume":"6","author":"Schnabel","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042608444476700_DEV132910C118","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1083\/jcb.201012049","article-title":"Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes","volume":"194","author":"Sdek","year":"2011","journal-title":"J. Cell Biol."},{"key":"2021042608444476700_DEV132910C119","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/(SICI)1097-0185(199707)248:3&lt;421::AID-AR15&gt;3.0.CO;2-R","article-title":"Developmental changes in the myocardial architecture of the chick","volume":"248","author":"Sedmera","year":"1997","journal-title":"Anat. Rec."},{"key":"2021042608444476700_DEV132910C120","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/(SICI)1097-0185(20000401)258:4&lt;319::AID-AR1&gt;3.0.CO;2-O","article-title":"Developmental patterning of the myocardium","volume":"258","author":"Sedmera","year":"2000","journal-title":"Anat. Rec."},{"key":"2021042608444476700_DEV132910C121","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature11682","article-title":"Mammalian heart renewal by pre-existing cardiomyocytes","volume":"493","author":"Senyo","year":"2013","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C122","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/210504a0","article-title":"Cell multiplication rates during development of the primitive cardiac tube in the chick embryo","volume":"210","author":"Sissman","year":"1966","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C123","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/CIRCULATIONAHA.110.980607","article-title":"Formation of the building plan of the human heart: morphogenesis, growth, and differentiation","volume":"123","author":"Sizarov","year":"2011","journal-title":"Circulation"},{"key":"2021042608444476700_DEV132910C124","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/nature10188","article-title":"De novo cardiomyocytes from within the activated adult heart after injury","volume":"474","author":"Smart","year":"2011","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C125","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart repair by reprogramming non-myocytes with cardiac transcription factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C126","first-page":"H2183","article-title":"Cardiomyocyte DNA synthesis and binucleation during murine development","volume":"271","author":"Soonpaa","year":"1996","journal-title":"Am. J. Physiol."},{"key":"2021042608444476700_DEV132910C127","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1172\/JCI119453","article-title":"Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice","volume":"99","author":"Soonpaa","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2021042608444476700_DEV132910C128","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.cell.2015.10.037","article-title":"Cardiomyocyte cell-cycle activity during preadolescence","volume":"163","author":"Soonpaa","year":"2015","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C129","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1161\/01.RES.0000239407.45137.97","article-title":"Regionalized sequence of myocardial cell growth and proliferation characterizes early chamber formation","volume":"99","author":"Soufan","year":"2006","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C130","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1242\/dev.098632","article-title":"High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation","volume":"141","author":"Staudt","year":"2014","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C131","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/S0012-1606(02)00078-7","article-title":"Erythropoietin and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation","volume":"255","author":"Stuckmann","year":"2003","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C132","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.114.011490","article-title":"The fetal mammalian heart generates a robust compensatory response to cell loss","volume":"132","author":"Sturzu","year":"2015","journal-title":"Circulation"},{"key":"2021042608444476700_DEV132910C134","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"2021042608444476700_DEV132910C135","doi-asserted-by":"publisher","first-page":"279ra38","DOI":"10.1126\/scitranslmed.3010841","article-title":"A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice","volume":"7","author":"Tian","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"2021042608444476700_DEV132910C136","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/nm.3764","article-title":"An emerging consensus on cardiac regeneration","volume":"20","author":"van Berlo","year":"2014","journal-title":"Nat. Med."},{"key":"2021042608444476700_DEV132910C137","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature13309","article-title":"c-kit+ cells minimally contribute cardiomyocytes to the heart","volume":"509","author":"van Berlo","year":"2014","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C138","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1161\/CIRCRESAHA.108.185843","article-title":"A caudal proliferating growth center contributes to both poles of the forming heart tube","volume":"104","author":"van den Berg","year":"2009","journal-title":"Circ. Res."},{"key":"2021042608444476700_DEV132910C139","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1073\/pnas.1116136109","article-title":"YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy","volume":"109","author":"von Gise","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C140","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/dev.128.16.3179","article-title":"Conotruncal myocardium arises from a secondary heart field","volume":"128","author":"Waldo","year":"2001","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C141","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S0092-8674(00)81436-1","article-title":"Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4","volume":"93","author":"Wang","year":"1998","journal-title":"Cell"},{"key":"2021042608444476700_DEV132910C142","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1242\/dev.068601","article-title":"The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion","volume":"138","author":"Wang","year":"2011","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C143","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature14325","article-title":"Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling","volume":"522","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C144","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nature15372","article-title":"Epicardial FSTL1 reconstitution regenerates the adult mammalian heart","volume":"525","author":"Wei","year":"2015","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C145","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1242\/dev.010363","article-title":"Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish","volume":"135","author":"Wills","year":"2008","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C146","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ydbio.2011.03.021","article-title":"Recapitulation of developmental cardiogenesis governs the morphological and functional regeneration of adult newt hearts following injury","volume":"354","author":"Witman","year":"2011","journal-title":"Dev. Biol."},{"key":"2021042608444476700_DEV132910C147","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1242\/dev.126.16.3597","article-title":"Inactivation of erythropoietin leads to defects in cardiac morphogenesis","volume":"126","author":"Wu","year":"1999","journal-title":"Development"},{"key":"2021042608444476700_DEV132910C148","first-page":"ra70","article-title":"Regulation of Insulin-like growth factor signaling by Yap governrs cardiomyocyte proliferation and embryonic heart size","volume":"25","author":"Xin","year":"2011","journal-title":"Sci. Signal."},{"key":"2021042608444476700_DEV132910C149","doi-asserted-by":"publisher","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608444476700_DEV132910C150","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0002-9149(73)91034-5","article-title":"Cell proliferation during cardiac growth","volume":"31","author":"Zak","year":"1973","journal-title":"Am. J. Cardiol."},{"key":"2021042608444476700_DEV132910C152","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nature12322","article-title":"In vivo cardiac reprogramming contributes to zebrafish heart regeneration","volume":"498","author":"Zhang","year":"2013","journal-title":"Nature"},{"key":"2021042608444476700_DEV132910C153","doi-asserted-by":"publisher","first-page":"10261","DOI":"10.1074\/jbc.273.17.10261","article-title":"Neuregulins promote survival and growth of cardiac myocytes: persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes","volume":"273","author":"Zhao","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021042608444476700_DEV132910C154","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev."},{"key":"2021042608444476700_DEV132910C155","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1161\/CIRCRESAHA.116.303311","article-title":"The Hippo pathway in heart development, regeneration, and diseases","volume":"116","author":"Zhou","year":"2015","journal-title":"Circ. Res."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.132910","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/143\/5\/729\/1844866\/dev132910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/143\/5\/729\/1844866\/dev132910.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T18:16:46Z","timestamp":1654453006000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/143\/5\/729\/47774\/Building-and-re-building-the-heart-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":155,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,3,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.132910","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3,1]]}}}