{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:01:42Z","timestamp":1791219702457,"version":"4.1.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"13","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:p>Mammalian teeth harbour mesenchymal stem cells (MSCs), which contribute to tooth growth and repair. These dental MSCs possess many in vitro features of bone marrow-derived MSCs, including clonogenicity, expression of certain markers, and following stimulation, differentiation into cells that have the characteristics of osteoblasts, chondrocytes and adipocytes. Teeth and their support tissues provide not only an easily accessible source of MSCs but also a tractable model system to study their function and properties in vivo. In addition, the accessibility of teeth together with their clinical relevance provides a valuable opportunity to test stem cell-based treatments for dental disorders. This Review outlines some recent discoveries in dental MSC function and behaviour and discusses how these and other advances are paving the way for the development of new biologically based dental therapies.<\/jats:p>","DOI":"10.1242\/dev.134189","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T07:38:01Z","timestamp":1467704281000},"page":"2273-2280","source":"Crossref","is-referenced-by-count":282,"title":["Dental mesenchymal stem cells"],"prefix":"10.1242","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-9561","authenticated-orcid":false,"given":"Paul T.","family":"Sharpe","sequence":"first","affiliation":[{"name":"Department of Craniofacial Development and Stem Cell Biology, Dental Institute, Kings College London, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608285714500_DEV134189C1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cell.2009.07.049","article-title":"Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin","volume":"139","author":"Adameyko","year":"2009","journal-title":"Cell"},{"key":"2021042608285714500_DEV134189C2","doi-asserted-by":"publisher","first-page":"238ra69","DOI":"10.1126\/scitranslmed.3008234","article-title":"Photoactivation of endogenous latent transforming growth factor-\u03b21 directs dental stem cell differentiation for regeneration","volume":"6","author":"Arany","year":"2014","journal-title":"Sci. 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