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Mutations in the ROR2 gene cause recessive Robinow syndrome in humans, a short-limbed dwarfism associated with craniofacial malformations. Here, we show that Ror2 is required for local upregulation of gdf6 at the neural plate border in Xenopus embryos. Ror2 morphant embryos fail to upregulate neural plate border genes and show defects in the induction of neural crest cell fate. These embryos lack the spatially restricted activation of BMP signaling at the neural plate border at early neurula stages, which is required for neural crest induction. Ror2-dependent planar cell polarity signaling is required in the dorsolateral marginal zone during gastrulation indirectly to upregulate the BMP ligand Gdf6 at the neural plate border and Gdf6 is sufficient to rescue neural plate border specification in Ror2 morphant embryos. Thereby, Ror2 links Wnt\/planar cell polarity signaling to BMP signaling in neural plate border specification and neural crest induction.<\/jats:p>","DOI":"10.1242\/dev.135426","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T11:27:37Z","timestamp":1472556457000},"page":"3182-3194","source":"Crossref","is-referenced-by-count":19,"title":["Ror2 signaling is required for local upregulation of GDF6 and activation of BMP signaling at the neural plate border"],"prefix":"10.1242","volume":"143","author":[{"given":"Carolin","family":"Schille","sequence":"first","affiliation":[{"name":"Biology Department, Developmental Biology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91058, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Bayerlov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, University Medical Center G\u00f6ttingen, G\u00f6ttingen 37073, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-9507","authenticated-orcid":false,"given":"Annalen","family":"Bleckmann","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, University Medical Center G\u00f6ttingen, G\u00f6ttingen 37073, Germany"},{"name":"Department of Hematology\/Medical Oncology, University Medical Center G\u00f6ttingen, G\u00f6ttingen 37099, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8771-5487","authenticated-orcid":false,"given":"Alexandra","family":"Schambony","sequence":"additional","affiliation":[{"name":"Biology Department, Developmental Biology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen 91058, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608355457500_DEV135426C1","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1101\/gad.12.16.2610","article-title":"Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways","volume":"12","author":"Axelrod","year":"1998","journal-title":"Genes Dev."},{"key":"2021042608355457500_DEV135426C2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1242\/dev.00238","article-title":"Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest","volume":"130","author":"Aybar","year":"2003","journal-title":"Development"},{"key":"2021042608355457500_DEV135426C3","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ydbio.2013.12.011","article-title":"Identification of Pax3 and Zic1 targets in the developing neural crest","volume":"386","author":"Bae","year":"2014","journal-title":"Dev. 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