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We explored the mechanisms underlying spermatogonial differentiation by targeting expression of a dominant-negative mutant of RA receptor \u03b1 (RAR\u03b1) specifically to the germ cells of transgenic mice to subvert the activity of endogenous receptors. Here we show that (i) inhibition of retinoid signaling in germ cells completely blocked spermatogonial differentiation identical to vitamin A-deficient (VAD) mice; (ii) the blockage of spermatogonial differentiation by impaired retinoid signaling resulted from an arrest of entry of the undifferentiated spermatogonia into S phase; and (iii) retinoid signaling regulated spermatogonial differentiation through controlling expression of its direct target genes including replication-dependent core histone genes. Altogether, our results demonstrate that the action of retinoid signaling on spermatogonial differentiation in vivo is direct through spermatogonia self, and provide the first evidence that this is mediated by regulation of expression of replication-dependent core histone genes.<\/jats:p>","DOI":"10.1242\/dev.135939","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T22:15:02Z","timestamp":1457648102000},"source":"Crossref","is-referenced-by-count":20,"title":["Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes"],"prefix":"10.1242","author":[{"given":"Yao","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"},{"name":"Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn","family":"Hogarth","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wei","sequence":"additional","affiliation":[{"name":"CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Griswold","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Han","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"},{"name":"Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608502564900_DEV135939C1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ydbio.2006.02.027","article-title":"Sohlh1 is essential for spermatogonial differentiation","volume":"294","author":"Ballow","year":"2006","journal-title":"Dev. 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