{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:28:06Z","timestamp":1773804486315,"version":"3.50.1"},"reference-count":71,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS088219"],"award-info":[{"award-number":["R01NS088219"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["F30CA192832"],"award-info":[{"award-number":["F30CA192832"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016086"],"award-info":[{"award-number":["P30CA016086"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA151806"],"award-info":[{"award-number":["U01CA151806"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:p>Microcephaly and medulloblastoma may both result from mutations that compromise genomic stability. We report that ATR, which is mutated in the microcephalic disorder Seckel syndrome, sustains cerebellar growth by maintaining chromosomal integrity during postnatal neurogenesis. Atr deletion in cerebellar granule neuron progenitors (CGNPs) induced proliferation-associated DNA damage, p53 activation, apoptosis and cerebellar hypoplasia in mice. Co-deletions of either p53 or Bax and Bak prevented apoptosis in Atr-deleted CGNPs, but failed to fully rescue cerebellar growth. ATR-deficient CGNPs had impaired cell cycle checkpoint function and continued to proliferate, accumulating chromosomal abnormalities. RNA-Seq demonstrated that the transcriptional response to ATR-deficient proliferation was highly p53 dependent and markedly attenuated by p53 co-deletion. Acute ATR inhibition in vivo by nanoparticle-formulated VE-822 reproduced the developmental disruptions seen with Atr deletion. Genetic deletion of Atr blocked tumorigenesis in medulloblastoma-prone SmoM2 mice. Our data show that p53-driven apoptosis and cell cycle arrest \u2013 and, in the absence of p53, non-apoptotic cell death \u2013 redundantly limit growth in ATR-deficient progenitors. These mechanisms may be exploited for treatment of CGNP-derived medulloblastoma using ATR inhibition.<\/jats:p>","DOI":"10.1242\/dev.139022","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T11:22:27Z","timestamp":1477999347000},"page":"4038-4052","source":"Crossref","is-referenced-by-count":48,"title":["ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation"],"prefix":"10.1242","volume":"143","author":[{"given":"Patrick Y.","family":"Lang","sequence":"first","affiliation":[{"name":"School of Medicine, University of North Carolina 1 Department of Cell Biology and Physiology , , Chapel Hill, NC 27599 , USA"},{"name":"UNC School of Medicine, University of North Carolina 2 Department of Neurology , , Chapel Hill, NC 27599 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gouri J.","family":"Nanjangud","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Research Center 3 Molecular Cytogenetics Core Facility , , New York, NY 10021 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Sokolsky-Papkov","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery and 4 \u2008 Division of Molecular Pharmaceutics , , Chapel Hill, NC 27599 , USA"},{"name":"Eshelman School of Pharmacy, University of North Carolina 4 \u2008 Division of Molecular Pharmaceutics , , Chapel Hill, NC 27599 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Shaw","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Research Center 3 Molecular Cytogenetics Core Facility , , New York, NY 10021 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duhyeong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery and 4 \u2008 Division of Molecular Pharmaceutics , , Chapel Hill, NC 27599 , USA"},{"name":"Eshelman School of Pharmacy, University of North Carolina 4 \u2008 Division of Molecular Pharmaceutics , , Chapel Hill, NC 27599 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel S.","family":"Parker","sequence":"additional","affiliation":[{"name":"School of Medicine, University of North Carolina 5 Department of Genetics , , Chapel Hill, NC 27599 , USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina 6 , Chapel Hill, NC 27599 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander V.","family":"Kabanov","sequence":"additional","affiliation":[{"name":"Center for Nanotechnology in Drug Delivery and 4 \u2008 Division of Molecular Pharmaceutics , , Chapel Hill, NC 27599 , USA"},{"name":"Eshelman School of Pharmacy, University of North Carolina 4 \u2008 Division of Molecular Pharmaceutics , , Chapel Hill, NC 27599 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-6400","authenticated-orcid":false,"given":"Timothy R.","family":"Gershon","sequence":"additional","affiliation":[{"name":"UNC School of Medicine, University of North Carolina 2 Department of Neurology , , Chapel Hill, NC 27599 , USA"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina 6 , Chapel Hill, NC 27599 , USA"},{"name":"Neuroscience Center, University of North Carolina 7 , Chapel Hill, NC 27599 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2024061213121865600_DEV139022C1","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1101\/gad.914401","article-title":"Cell cycle checkpoint signaling through the ATM and ATR kinases","volume":"15","author":"Abraham","year":"2001","journal-title":"Genes Dev."},{"key":"2024061213121865600_DEV139022C2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0925-4773(01)00460-9","article-title":"A 1.8kb GFAP-promoter fragment is active in specific regions of the embryonic CNS","volume":"107","author":"Andrae","year":"2001","journal-title":"Mech. Dev."},{"key":"2024061213121865600_DEV139022C3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"2024061213121865600_DEV139022C4","article-title":"Near-optimal RNA-Seq quantification","author":"Bray","year":"2015","journal-title":"arXiv"},{"key":"2024061213121865600_DEV139022C5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1101\/gad.14.4.397","article-title":"ATR disruption leads to chromosomal fragmentation and early embryonic lethality","volume":"14","author":"Brown","year":"2000","journal-title":"Genes Dev."},{"key":"2024061213121865600_DEV139022C6","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1101\/gad.1067403","article-title":"Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance","volume":"17","author":"Brown","year":"2003","journal-title":"Genes Dev."},{"key":"2024061213121865600_DEV139022C7","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"2024061213121865600_DEV139022C8","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s10522-010-9261-z","article-title":"Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of phospho-ATR (ser428)","volume":"11","author":"Chandris","year":"2010","journal-title":"Biogerontology"},{"key":"2024061213121865600_DEV139022C9","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1021\/jm101488z","article-title":"Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents","volume":"54","author":"Charrier","year":"2011","journal-title":"J. Med. Chem."},{"key":"2024061213121865600_DEV139022C10","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1073\/pnas.97.2.889","article-title":"Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system","volume":"97","author":"Chong","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061213121865600_DEV139022C11","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bcp.2011.10.008","article-title":"Cdk1\/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration","volume":"83","author":"Chu","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"2024061213121865600_DEV139022C12","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061213121865600_DEV139022C13","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1101\/gad.214080.113","article-title":"ATR phosphorylates SMARCAL1 to prevent replication fork collapse","volume":"27","author":"Couch","year":"2013","journal-title":"Genes Dev."},{"key":"2024061213121865600_DEV139022C14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2024061213121865600_DEV139022C15","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1083\/jcb.201004096","article-title":"Clearance of apoptotic cells: implications in health and disease","volume":"189","author":"Elliott","year":"2010","journal-title":"J. Cell Biol."},{"key":"2024061213121865600_DEV139022C16","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1101\/gad.995802","article-title":"Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1\/eIF4E","volume":"16","author":"Fingar","year":"2002","journal-title":"Genes Dev."},{"key":"2024061213121865600_DEV139022C17","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s10549-011-1864-9","article-title":"Paclitaxel sensitivity of breast cancer cells requires efficient mitotic arrest and disruption of Bcl-xL\/Bak interaction","volume":"133","author":"Flores","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"2024061213121865600_DEV139022C18","doi-asserted-by":"publisher","first-page":"e441","DOI":"10.1038\/cddis.2012.181","article-title":"Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation","volume":"3","author":"Fokas","year":"2012","journal-title":"Cell Death Dis."},{"key":"2024061213121865600_DEV139022C19","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1038\/sj.emboj.7601703","article-title":"BRCA2 is required for neurogenesis and suppression of medulloblastoma","volume":"26","author":"Frappart","year":"2007","journal-title":"EMBO J."},{"key":"2024061213121865600_DEV139022C20","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1073\/pnas.0806882106","article-title":"Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency","volume":"106","author":"Frappart","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061213121865600_DEV139022C21","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/cdd.2009.44","article-title":"Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes","volume":"16","author":"Galluzzi","year":"2009","journal-title":"Cell Death Differ."},{"key":"2024061213121865600_DEV139022C22","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1038\/onc.2012.248","article-title":"Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation","volume":"32","author":"Garcia","year":"2013","journal-title":"Oncogene"},{"key":"2024061213121865600_DEV139022C23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/2049-3002-1-2","article-title":"Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma","volume":"1","author":"Gershon","year":"2013","journal-title":"Cancer Metab."},{"key":"2024061213121865600_DEV139022C24","doi-asserted-by":"publisher","first-page":"i451","DOI":"10.1093\/bioinformatics\/bts389","article-title":"EnrichNet: network-based gene set enrichment analysis","volume":"28","author":"Glaab","year":"2012","journal-title":"Bioinformatics"},{"key":"2024061213121865600_DEV139022C25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/ng.3451","article-title":"TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism","volume":"48","author":"Harley","year":"2016","journal-title":"Nat. Genet."},{"key":"2024061213121865600_DEV139022C26","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.dnarep.2010.06.002","article-title":"Radiation induced DNA DSBs: contribution from stalled replication forks","volume":"9","author":"Harper","year":"2010","journal-title":"DNA Repair"},{"key":"2024061213121865600_DEV139022C27","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1146\/annurev.ne.18.030195.002125","article-title":"Mechanisms of neural patterning and specification in the development cerebellum","volume":"18","author":"Hatten","year":"1995","journal-title":"Annu. Rev. Neurosci."},{"key":"2024061213121865600_DEV139022C28","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.tins.2011.01.002","article-title":"Development and cancer of the cerebellum","volume":"34","author":"Hatten","year":"2011","journal-title":"Trends Neurosci."},{"key":"2024061213121865600_DEV139022C29","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1126\/science.280.5366.1089","article-title":"Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system","volume":"280","author":"Herzog","year":"1998","journal-title":"Science"},{"key":"2024061213121865600_DEV139022C30","doi-asserted-by":"publisher","first-page":"7159","DOI":"10.1038\/sj.onc.1209704","article-title":"Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs","volume":"25","author":"Holcomb","year":"2006","journal-title":"Oncogene"},{"key":"2024061213121865600_DEV139022C31","volume-title":"An Internationl System for Human Cytogenetic Nomenclature","author":"ISCN","year":"2013"},{"key":"2024061213121865600_DEV139022C32","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/ng747","article-title":"Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer","volume":"29","author":"Jonkers","year":"2001","journal-title":"Nat. Genet."},{"key":"2024061213121865600_DEV139022C33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2024061213121865600_DEV139022C34","doi-asserted-by":"publisher","first-page":"9330","DOI":"10.1074\/jbc.M116.719740","article-title":"ATR kinase inhibition protects non-cycling cells from the lethal effects of DNA damage and transcription stress","volume":"291","author":"Kemp","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2024061213121865600_DEV139022C35","doi-asserted-by":"publisher","first-page":"D488","DOI":"10.1093\/nar\/gkv1024","article-title":"WikiPathways: capturing the full diversity of pathway knowledge","volume":"44","author":"Kutmon","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2024061213121865600_DEV139022C36","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"2024061213121865600_DEV139022C37","first-page":"6395","article-title":"DNA ligase IV suppresses medulloblastoma formation","volume":"62","author":"Lee","year":"2002","journal-title":"Cancer Res."},{"key":"2024061213121865600_DEV139022C38","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.neuroscience.2006.07.026","article-title":"Responding to DNA double strand breaks in the nervous system","volume":"145","author":"Lee","year":"2007","journal-title":"Neuroscience"},{"key":"2024061213121865600_DEV139022C39","doi-asserted-by":"publisher","first-page":"pii: 990","DOI":"10.3791\/990","article-title":"Isolation and culture of post-natal mouse cerebellar granule neuron progenitor cells and neurons","volume":"23","author":"Lee","year":"2009","journal-title":"J. Vis. Exp."},{"key":"2024061213121865600_DEV139022C40","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1038\/emboj.2011.493","article-title":"ATR maintains select progenitors during nervous system development","volume":"31","author":"Lee","year":"2012","journal-title":"EMBO J."},{"key":"2024061213121865600_DEV139022C41","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.dnarep.2009.04.006","article-title":"Common mechanisms of PIKK regulation","volume":"8","author":"Lovejoy","year":"2009","journal-title":"DNA Repair"},{"key":"2024061213121865600_DEV139022C42","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.1016\/j.biomaterials.2010.02.057","article-title":"Doubly amphiphilic poly(2-oxazoline)s as high-capacity delivery systems for hydrophobic drugs","volume":"31","author":"Luxenhofer","year":"2010","journal-title":"Biomaterials"},{"key":"2024061213121865600_DEV139022C43","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuron.2005.08.028","article-title":"Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors","volume":"48","author":"Machold","year":"2005","journal-title":"Neuron"},{"key":"2024061213121865600_DEV139022C44","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/dvdy.20551","article-title":"Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit","volume":"234","author":"Matei","year":"2005","journal-title":"Dev. Dyn."},{"key":"2024061213121865600_DEV139022C45","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/dvg.22788","article-title":"Generation of a Magoh conditional allele in mice","volume":"52","author":"McMahon","year":"2014","journal-title":"Genesis"},{"key":"2024061213121865600_DEV139022C46","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/nprot.2013.092","article-title":"Large-scale gene function analysis with the PANTHER classification system","volume":"8","author":"Mi","year":"2013","journal-title":"Nat. Protoc."},{"key":"2024061213121865600_DEV139022C47","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1128\/MMBR.00030-06","article-title":"Replication fork stalling at natural impediments","volume":"71","author":"Mirkin","year":"2007","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"2024061213121865600_DEV139022C48","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1042\/BJ20102162","article-title":"ATR signalling: more than meeting at the fork","volume":"436","author":"Nam","year":"2011","journal-title":"Biochem. J."},{"key":"2024061213121865600_DEV139022C49","doi-asserted-by":"publisher","DOI":"10.1038\/ng1129","article-title":"FusionCatcher - a tool for finding somatic fusion genes in paired-end RNA-sequencing data","author":"Nicorici","year":"2014","journal-title":"bioRxiv"},{"key":"2024061213121865600_DEV139022C50","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/ng1129","article-title":"A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome","volume":"33","author":"O'Driscoll","year":"2003","journal-title":"Nat. Genet."},{"key":"2024061213121865600_DEV139022C51","doi-asserted-by":"publisher","first-page":"10017","DOI":"10.1073\/pnas.0602436103","article-title":"Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development","volume":"103","author":"Orii","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061213121865600_DEV139022C52","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2014"},{"key":"2024061213121865600_DEV139022C53","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cell.2011.12.013","article-title":"Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations","volume":"148","author":"Rausch","year":"2012","journal-title":"Cell"},{"key":"2024061213121865600_DEV139022C54","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2024061213121865600_DEV139022C55","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1093\/hmg\/ddv115","article-title":"Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability","volume":"24","author":"Rosin","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2024061213121865600_DEV139022C56","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ccr.2008.07.005","article-title":"Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma","volume":"14","author":"Schuller","year":"2008","journal-title":"Cancer Cell"},{"key":"2024061213121865600_DEV139022C57","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"2024061213121865600_DEV139022C58","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024061213121865600_DEV139022C59","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/B978-0-12-380888-2.00003-0","article-title":"The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer","volume":"108","author":"Smith","year":"2010","journal-title":"Adv. Cancer Res."},{"key":"2024061213121865600_DEV139022C60","doi-asserted-by":"publisher","first-page":"13638","DOI":"10.1074\/jbc.M802027200","article-title":"Roles of Pofut1 and O-fucose in mammalian Notch signaling","volume":"283","author":"Stahl","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2024061213121865600_DEV139022C61","doi-asserted-by":"publisher","first-page":"11272","DOI":"10.1073\/pnas.0504783102","article-title":"Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease","volume":"102","author":"Takeuchi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061213121865600_DEV139022C62","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0002-9440(10)63825-4","article-title":"Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(\u2212\/\u2212) mice","volume":"162","author":"Tong","year":"2003","journal-title":"Am. J. Pathol."},{"key":"2024061213121865600_DEV139022C63","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/sj.cdd.4402286","article-title":"DNA damage induces two distinct modes of cell death in ovarian carcinomas","volume":"15","author":"Vakifahmetoglu","year":"2008","journal-title":"Cell Death Differ."},{"key":"2024061213121865600_DEV139022C64","doi-asserted-by":"publisher","first-page":"32513","DOI":"10.1074\/jbc.M111.225862","article-title":"Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzyme","volume":"286","author":"Walsh","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2024061213121865600_DEV139022C65","doi-asserted-by":"publisher","first-page":"e178","DOI":"10.1093\/nar\/gkq622","article-title":"MapSplice: accurate mapping of RNA-seq reads for splice junction discovery","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2024061213121865600_DEV139022C66","doi-asserted-by":"publisher","first-page":"W77","DOI":"10.1093\/nar\/gkt439","article-title":"WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013","volume":"41","author":"Wang","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2024061213121865600_DEV139022C67","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1242\/dev.124271","article-title":"Aspm sustains postnatal cerebellar neurogenesis and medulloblastoma growth in mice","volume":"142","author":"Williams","year":"2015","journal-title":"Development"},{"key":"2024061213121865600_DEV139022C68","doi-asserted-by":"publisher","first-page":"10592","DOI":"10.1073\/pnas.1301445110","article-title":"APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress","volume":"110","author":"Willis","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061213121865600_DEV139022C69","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ccr.2008.07.003","article-title":"Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells","volume":"14","author":"Yang","year":"2008","journal-title":"Cancer Cell"},{"key":"2024061213121865600_DEV139022C70","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/gene.10008","article-title":"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo","volume":"31","author":"Zhuo","year":"2001","journal-title":"Genesis"},{"key":"2024061213121865600_DEV139022C71","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2584","article-title":"Tumour suppression by p53: the importance of apoptosis and cellular senescence","volume":"219","author":"Zuckerman","year":"2009","journal-title":"J. Pathol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.139022","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/143\/21\/4038\/3471801\/dev139022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/143\/21\/4038\/3471801\/dev139022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:33:10Z","timestamp":1718199190000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/143\/21\/4038\/47627\/ATR-maintains-chromosomal-integrity-during"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,1]]},"references-count":71,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2016,11,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.139022","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11,1]]}}}