{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:36:53Z","timestamp":1791571013799,"version":"4.3.4"},"reference-count":141,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T00:00:00Z","timestamp":1531612800000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK056638"],"award-info":[{"award-number":["DK056638"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL069438"],"award-info":[{"award-number":["HL069438"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["LLS-TRP 6475-15"],"award-info":[{"award-number":["LLS-TRP 6475-15"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["NYSTEM IIRP C029570"],"award-info":[{"award-number":["NYSTEM IIRP C029570"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004856","name":"New York State Department of Health","doi-asserted-by":"publisher","award":["C029154"],"award-info":[{"award-number":["C029154"]}],"id":[{"id":"10.13039\/100004856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.<\/jats:p>","DOI":"10.1242\/dev.139691","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T01:11:05Z","timestamp":1516669865000},"source":"Crossref","is-referenced-by-count":236,"title":["The hematopoietic stem cell niche: from embryo to adult"],"prefix":"10.1242","volume":"145","author":[{"given":"Xin","family":"Gao","sequence":"first","affiliation":[{"name":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine 1 , Bronx, New York, NY 10461 , USA"},{"name":"Albert Einstein College of Medicine 2 Departments of Medicine and Cell Biology , , Bronx, New York, NY 10461 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliang","family":"Xu","sequence":"additional","affiliation":[{"name":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine 1 , Bronx, New York, NY 10461 , USA"},{"name":"Albert Einstein College of Medicine 2 Departments of Medicine and Cell Biology , , Bronx, New York, NY 10461 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Asada","sequence":"additional","affiliation":[{"name":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine 1 , Bronx, New York, NY 10461 , USA"},{"name":"Albert Einstein College of Medicine 2 Departments of Medicine and Cell Biology , , Bronx, New York, NY 10461 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0862-9922","authenticated-orcid":false,"given":"Paul S.","family":"Frenette","sequence":"additional","affiliation":[{"name":"Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine 1 , Bronx, New York, NY 10461 , USA"},{"name":"Albert Einstein College of Medicine 2 Departments of Medicine and Cell Biology , , Bronx, New York, NY 10461 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"2024061223452308200_DEV139691C1","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1182\/blood-2002-03-0822","article-title":"Evidence that the number of hematopoietic stem cells per animal is conserved in mammals","volume":"100","author":"Abkowitz","year":"2002","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C2","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.2337\/db14-1473","article-title":"Bone marrow macrophages contribute to diabetic stem cell mobilopathy by producing Oncostatin M","volume":"64","author":"Albiero","year":"2015","journal-title":"Diabetes"},{"key":"2024061223452308200_DEV139691C3","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1056\/NEJMp078166","article-title":"Hematopoietic-cell transplantation at 50","volume":"357","author":"Appelbaum","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"2024061223452308200_DEV139691C4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1196\/annals.1392.005","article-title":"Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche","volume":"1106","author":"Arai","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2024061223452308200_DEV139691C5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nature13383","article-title":"Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms","volume":"512","author":"Arranz","year":"2014","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/ncb3475","article-title":"Differential cytokine contributions of perivascular haematopoietic stem cell niches","volume":"19","author":"Asada","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2024061223452308200_DEV139691C7","first-page":"174","article-title":"Sl\/Sld hematopoietic progenitors are deficient in situ","volume":"22","author":"Barker","year":"1994","journal-title":"Exp. Hematol."},{"key":"2024061223452308200_DEV139691C8","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.yexcr.2014.09.013","article-title":"Epigenetic regulation of hematopoietic stem cell aging","volume":"329","author":"Beerman","year":"2014","journal-title":"Exp. Cell Res."},{"key":"2024061223452308200_DEV139691C9","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.bbadis.2009.01.008","article-title":"Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone loss","volume":"1792","author":"Bellantuono","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"2024061223452308200_DEV139691C10","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1182\/blood-2005-02-0461","article-title":"Three pathways to mature macrophages in the early mouse yolk sac","volume":"106","author":"Bertrand","year":"2005","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C11","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1242\/dev.02510","article-title":"Fetal spleen stroma drives macrophage commitment","volume":"133","author":"Bertrand","year":"2006","journal-title":"Development"},{"key":"2024061223452308200_DEV139691C12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature08738","article-title":"Haematopoietic stem cells derive directly from aortic endothelium during development","volume":"464","author":"Bertrand","year":"2010","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/nyas.13016","article-title":"Niche heterogeneity in the bone marrow","volume":"1370","author":"Birbrair","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2024061223452308200_DEV139691C14","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.stem.2013.08.012","article-title":"Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells","volume":"13","author":"B\u00f6iers","year":"2013","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C15","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nature08764","article-title":"In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium","volume":"464","author":"Boisset","year":"2010","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C16","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1172\/JCI28310","article-title":"Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect","volume":"116","author":"Bowie","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2024061223452308200_DEV139691C17","doi-asserted-by":"publisher","first-page":"5878","DOI":"10.1073\/pnas.0700460104","article-title":"Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties","volume":"104","author":"Bowie","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C18","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/nm.3707","article-title":"Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion","volume":"20","author":"Bruns","year":"2014","journal-title":"Nat. Med."},{"key":"2024061223452308200_DEV139691C19","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.stem.2010.02.001","article-title":"Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells","volume":"6","author":"Butler","year":"2010","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C20","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C21","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.cell.2013.04.040","article-title":"Rhythmic modulation of the hematopoietic niche through neutrophil clearance","volume":"153","author":"Casanova-Acebes","year":"2013","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C22","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1182\/blood-2002-05-1341","article-title":"Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition","volume":"101","author":"Chagraoui","year":"2003","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C23","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.stem.2011.10.003","article-title":"Erythroid\/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells","volume":"9","author":"Chen","year":"2011","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C24","doi-asserted-by":"publisher","first-page":"7799","DOI":"10.1073\/pnas.1003586107","article-title":"Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells","volume":"107","author":"Chou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C25","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.exphem.2013.02.003","article-title":"Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells","volume":"41","author":"Chou","year":"2013","journal-title":"Exp. Hematol."},{"key":"2024061223452308200_DEV139691C26","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1084\/jem.20101688","article-title":"Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche","volume":"208","author":"Chow","year":"2011","journal-title":"J. Exp. Med."},{"key":"2024061223452308200_DEV139691C27","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1371\/journal.pbio.0020075","article-title":"Circulation and chemotaxis of fetal hematopoietic stem cells","volume":"2","author":"Christensen","year":"2004","journal-title":"PLoS Biol."},{"key":"2024061223452308200_DEV139691C28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/00062752-200701000-00003","article-title":"Regulation of neutrophil homeostasis","volume":"14","author":"Christopher","year":"2007","journal-title":"Curr. Opin Hematol."},{"key":"2024061223452308200_DEV139691C29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1084\/jem.20101700","article-title":"Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice","volume":"208","author":"Christopher","year":"2011","journal-title":"J. Exp. Med."},{"key":"2024061223452308200_DEV139691C30","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.immuni.2016.11.004","article-title":"Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation","volume":"45","author":"Cordeiro Gomes","year":"2016","journal-title":"Immunity"},{"key":"2024061223452308200_DEV139691C31","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.celrep.2014.09.013","article-title":"Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells","volume":"9","author":"Co\u015fkun","year":"2014","journal-title":"Cell Rep."},{"key":"2024061223452308200_DEV139691C32","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1242\/dev.114231","article-title":"The many faces of hematopoietic stem cell heterogeneity","volume":"143","author":"Crisan","year":"2016","journal-title":"Development"},{"key":"2024061223452308200_DEV139691C33","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1093\/emboj\/19.11.2465","article-title":"Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo","volume":"19","author":"de Bruijn","year":"2000","journal-title":"EMBO J."},{"key":"2024061223452308200_DEV139691C34","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S1074-7613(02)00313-8","article-title":"Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta","volume":"16","author":"de Bruijn","year":"2002","journal-title":"Immunity"},{"key":"2024061223452308200_DEV139691C35","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1182\/blood.V89.5.1543","article-title":"Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity","volume":"89","author":"de Haan","year":"1997","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C36","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11885","article-title":"Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches","volume":"495","author":"Ding","year":"2013","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C37","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C38","first-page":"1172","article-title":"Mesenchymal lineage potentials of aorta-gonad-mesonephros stromal clones","volume":"91","author":"Durand","year":"2006","journal-title":"Haematologica"},{"key":"2024061223452308200_DEV139691C39","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1084\/jem.20111490","article-title":"Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells","volume":"208","author":"Dykstra","year":"2011","journal-title":"J. Exp. Med."},{"key":"2024061223452308200_DEV139691C40","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/ni1560","article-title":"Of lineage and legacy: the development of mammalian hematopoietic stem cells","volume":"9","author":"Dzierzak","year":"2008","journal-title":"Nat. Immunol."},{"key":"2024061223452308200_DEV139691C41","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1182\/blood.V95.7.2284","article-title":"Expansion of hematopoietic stem cells in the developing liver of a mouse embryo","volume":"95","author":"Ema","year":"2000","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C42","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1182\/blood-2011-11-391730","article-title":"Rantes\/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing","volume":"119","author":"Ergen","year":"2012","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C43","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.stem.2012.07.002","article-title":"Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis","volume":"11","author":"Fitch","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C44","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/nature13619","article-title":"Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells","volume":"512","author":"Flach","year":"2014","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C45","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1182\/blood-2011-04-348151","article-title":"Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia","volume":"119","author":"Frisch","year":"2012","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C46","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature10160","article-title":"In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche","volume":"474","author":"Fujisaki","year":"2011","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C47","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nri3433","article-title":"The ageing haematopoietic stem cell compartment","volume":"13","author":"Geiger","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2024061223452308200_DEV139691C48","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.devcel.2004.12.016","article-title":"The placenta is a niche for hematopoietic stem cells","volume":"8","author":"Gekas","year":"2005","journal-title":"Dev. Cell"},{"key":"2024061223452308200_DEV139691C49","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1387\/ijdb.103070cg","article-title":"Hematopoietic stem cell development in the placenta","volume":"54","author":"Gekas","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"2024061223452308200_DEV139691C50","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C51","doi-asserted-by":"publisher","first-page":"840","DOI":"10.15252\/embj.201694969","article-title":"Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells","volume":"36","author":"Guidi","year":"2017","journal-title":"EMBO J."},{"key":"2024061223452308200_DEV139691C52","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.stem.2014.06.020","article-title":"Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche","volume":"15","author":"Hanoun","year":"2014","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C53","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.stem.2009.01.006","article-title":"Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells","volume":"4","author":"Hooper","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C54","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1073\/pnas.89.4.1502","article-title":"Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation","volume":"89","author":"Ikuta","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C55","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature17624","article-title":"Distinct bone marrow blood vessels differentially regulate haematopoiesis","volume":"532","author":"Itkin","year":"2016","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C56","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1084\/jem.20111688","article-title":"Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region","volume":"208","author":"Ivanovs","year":"2011","journal-title":"J. Exp. Med."},{"key":"2024061223452308200_DEV139691C57","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1242\/dev.125.22.4575","article-title":"Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny","volume":"125","author":"Jaffredo","year":"1998","journal-title":"Development"},{"key":"2024061223452308200_DEV139691C58","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1634\/stemcells.2004-0066","article-title":"Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging","volume":"23","author":"Kamminga","year":"2005","journal-title":"Stem Cells"},{"key":"2024061223452308200_DEV139691C59","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.cell.2005.10.041","article-title":"Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow","volume":"124","author":"Katayama","year":"2006","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C60","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1126\/science.aad0084","article-title":"Fetal liver hematopoietic stem cell niches associate with portal vessels","volume":"351","author":"Khan","year":"2016","journal-title":"Science"},{"key":"2024061223452308200_DEV139691C61","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C62","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.stem.2007.06.001","article-title":"Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance","volume":"1","author":"Kiel","year":"2007","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C63","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1182\/blood-2003-12-4162","article-title":"Yolk sac-derived primitive erythroblasts enucleate during mammalian embryogenesis","volume":"104","author":"Kingsley","year":"2004","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C64","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature08761","article-title":"Blood stem cells emerge from aortic endothelium by a novel type of cell transition","volume":"464","author":"Kissa","year":"2010","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C65","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/ncb2108","article-title":"Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells","volume":"12","author":"Kobayashi","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"2024061223452308200_DEV139691C66","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nature12883","article-title":"Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts","volume":"506","author":"Kode","year":"2014","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C67","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/nm.3364","article-title":"Differential regulation of myeloid leukemias by the bone marrow microenvironment","volume":"19","author":"Krause","year":"2013","journal-title":"Nat. Med."},{"key":"2024061223452308200_DEV139691C68","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nature12612","article-title":"Arteriolar niches maintain haematopoietic stem cell quiescence","volume":"502","author":"Kunisaki","year":"2013","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C69","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C70","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nature17638","article-title":"Age-dependent modulation of vascular niches for haematopoietic stem cells","volume":"532","author":"Kusumbe","year":"2016","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C71","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.devcel.2005.02.005","article-title":"Finding the hematopoietic stem cell niche in the placenta","volume":"8","author":"Li","year":"2005","journal-title":"Dev. Cell"},{"key":"2024061223452308200_DEV139691C72","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nm.3155","article-title":"Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration","volume":"19","author":"Lucas","year":"2013","journal-title":"Nat. Med."},{"key":"2024061223452308200_DEV139691C73","doi-asserted-by":"publisher","first-page":"4645","DOI":"10.1182\/blood-2009-06-230037","article-title":"Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling","volume":"114","author":"Mascarenhas","year":"2009","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C74","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1182\/blood.V98.1.6","article-title":"Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region-derived stromal cells","volume":"98","author":"Matsuoka","year":"2001","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C75","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1016\/j.celrep.2015.05.036","article-title":"Distinct sources of hematopoietic progenitors emerge before HSCs and provide functional blood cells in the mammalian embryo","volume":"11","author":"McGrath","year":"2015","journal-title":"Cell Rep."},{"key":"2024061223452308200_DEV139691C76","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S0092-8674(00)80165-8","article-title":"Definitive hematopoiesis is autonomously initiated by the AGM region","volume":"86","author":"Medvinsky","year":"1996","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C77","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1242\/dev.040998","article-title":"Embryonic origin of the adult hematopoietic system: advances and questions","volume":"138","author":"Medvinsky","year":"2011","journal-title":"Development"},{"key":"2024061223452308200_DEV139691C78","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nature06685","article-title":"Haematopoietic stem cell release is regulated by circadian oscillations","volume":"452","author":"M\u00e9ndez-Ferrer","year":"2008","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C79","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M\u00e9ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C80","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1182\/blood.V89.12.4337","article-title":"In vitro maintenance of highly purified, transplantable hematopoietic stem cells","volume":"89","author":"Moore","year":"1997","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C81","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1073\/pnas.94.8.4011","article-title":"Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs","volume":"94","author":"Moore","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C82","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.exphem.2010.12.008","article-title":"Functional characterization of hematopoietic stem cells in the spleen","volume":"39","author":"Morita","year":"2011","journal-title":"Exp. Hematol."},{"key":"2024061223452308200_DEV139691C83","doi-asserted-by":"publisher","first-page":"10302","DOI":"10.1073\/pnas.92.22.10302","article-title":"The purification and characterization of fetal liver hematopoietic stem cells","volume":"92","author":"Morrison","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C84","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/nm0996-1011","article-title":"The aging of hematopoietic stem cells","volume":"2","author":"Morrison","year":"1996","journal-title":"Nat. Med."},{"key":"2024061223452308200_DEV139691C85","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/1074-7613(94)90081-7","article-title":"Development of hematopoietic stem cell activity in the mouse embryo","volume":"1","author":"M\u00fcller","year":"1994","journal-title":"Immunity"},{"key":"2024061223452308200_DEV139691C86","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s12185-014-1641-8","article-title":"Aging of the hematopoietic stem cells niche","volume":"100","author":"Nakamura-Ishizu","year":"2014","journal-title":"Int. J. Hematol."},{"key":"2024061223452308200_DEV139691C87","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.bbrc.2014.10.095","article-title":"Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin","volume":"454","author":"Nakamura-Ishizu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024061223452308200_DEV139691C88","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1084\/jem.20150057","article-title":"CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow","volume":"212","author":"Nakamura-Ishizu","year":"2015","journal-title":"J. Exp. Med."},{"key":"2024061223452308200_DEV139691C89","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1038\/ncomms2569","article-title":"Haemogenic endocardium contributes to transient definitive haematopoiesis","volume":"4","author":"Nakano","year":"2013","journal-title":"Nat. Commun."},{"key":"2024061223452308200_DEV139691C90","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nature08099","article-title":"Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment","volume":"460","author":"Naveiras","year":"2009","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C91","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/sj.leu.2402371","article-title":"The AFT024 stromal cell line supports long-term ex vivo maintenance of engrafting multipotent human hematopoietic progenitors","volume":"16","author":"Nolta","year":"2002","journal-title":"Leukemia"},{"key":"2024061223452308200_DEV139691C92","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1182\/blood.V92.3.908","article-title":"Hematopoietic stem cell maintenance and differentiation are supported by embryonic aorta-gonad-mesonephros region-derived endothelium","volume":"92","author":"Ohneda","year":"1998","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C93","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.immuni.2010.08.017","article-title":"The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche","volume":"33","author":"Omatsu","year":"2010","journal-title":"Immunity"},{"key":"2024061223452308200_DEV139691C94","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1182\/blood.V99.4.1183","article-title":"Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity","volume":"99","author":"Oostendorp","year":"2002","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C95","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1242\/jcs.115.10.2099","article-title":"Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis","volume":"115","author":"Oostendorp","year":"2002","journal-title":"J. Cell Sci."},{"key":"2024061223452308200_DEV139691C96","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1634\/stemcells.2004-0120","article-title":"Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures","volume":"23","author":"Oostendorp","year":"2005","journal-title":"Stem Cells"},{"key":"2024061223452308200_DEV139691C97","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C98","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.devcel.2005.02.001","article-title":"The murine placenta contains hematopoietic stem cells within the vascular labyrinth region","volume":"8","author":"Ottersbach","year":"2005","journal-title":"Dev. Cell"},{"key":"2024061223452308200_DEV139691C99","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fphys.2014.00003","article-title":"Primitive and definitive erythropoiesis in mammals","volume":"5","author":"Palis","year":"2014","journal-title":"Front. Physiol."},{"key":"2024061223452308200_DEV139691C100","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1242\/dev.126.22.5073","article-title":"Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse","volume":"126","author":"Palis","year":"1999","journal-title":"Development"},{"key":"2024061223452308200_DEV139691C101","doi-asserted-by":"publisher","first-page":"4528","DOI":"10.1073\/pnas.071002398","article-title":"Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis","volume":"98","author":"Palis","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C102","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1242\/dev.034728","article-title":"Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development","volume":"136","author":"Peeters","year":"2009","journal-title":"Development"},{"key":"2024061223452308200_DEV139691C103","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.stem.2017.01.002","article-title":"Cholinergic signals from the CNS regulate G-CSF-mediated HSC mobilization from bone marrow via a glucocorticoid signaling relay","volume":"20","author":"Pierce","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C104","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1084\/jem.20122252","article-title":"PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion","volume":"210","author":"Pinho","year":"2013","journal-title":"J. Exp. Med."},{"key":"2024061223452308200_DEV139691C105","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.celrep.2013.07.048","article-title":"Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis","volume":"4","author":"Poulos","year":"2013","journal-title":"Cell Rep."},{"key":"2024061223452308200_DEV139691C106","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/nature08851","article-title":"Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia","volume":"464","author":"Raaijmakers","year":"2010","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C107","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature13146","article-title":"Endothelial Notch activity promotes angiogenesis and osteogenesis in bone","volume":"507","author":"Ramasamy","year":"2014","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C108","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.stem.2008.01.001","article-title":"The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation","volume":"2","author":"Rhodes","year":"2008","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C109","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.devcel.2006.07.002","article-title":"An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells","volume":"11","author":"Robin","year":"2006","journal-title":"Dev. Cell"},{"key":"2024061223452308200_DEV139691C110","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.stem.2009.08.020","article-title":"Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development","volume":"5","author":"Robin","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C111","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nature12602","article-title":"Spatial organization within a niche as a determinant of stem-cell fate","volume":"502","author":"Rompolas","year":"2013","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C112","doi-asserted-by":"publisher","first-page":"9194","DOI":"10.1073\/pnas.0503280102","article-title":"Cell intrinsic alterations underlie hematopoietic stem cell aging","volume":"102","author":"Rossi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C113","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.stemcr.2014.07.009","article-title":"Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor","volume":"3","author":"Rybtsov","year":"2014","journal-title":"Stem Cell Rep."},{"key":"2024061223452308200_DEV139691C114","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","article-title":"Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment","volume":"131","author":"Sacchetti","year":"2007","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C115","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.stem.2013.06.009","article-title":"Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche","volume":"13","author":"Schepers","year":"2013","journal-title":"Cell Stem Cell"},{"key":"2024061223452308200_DEV139691C116","first-page":"7","article-title":"The relationship between the spleen colony-forming cell and the haemopoietic stem cell","volume":"4","author":"Schofield","year":"1978","journal-title":"Blood Cells"},{"key":"2024061223452308200_DEV139691C117","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bone.2016.01.014","article-title":"Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage","volume":"85","author":"Singh","year":"2016","journal-title":"Bone"},{"key":"2024061223452308200_DEV139691C118","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1084\/jem.192.9.1273","article-title":"Age-associated characteristics of murine hematopoietic stem cells","volume":"192","author":"Sudo","year":"2000","journal-title":"J. Exp. Med."},{"key":"2024061223452308200_DEV139691C119","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1080\/10245332.1999.11746468","article-title":"The hematopoietic microenvironment: osteoblasts and the hematopoietic microenvironment","volume":"4","author":"Taichman","year":"2000","journal-title":"Hematology"},{"key":"2024061223452308200_DEV139691C120","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1126\/science.1213214","article-title":"Interconversion between intestinal stem cell populations in distinct niches","volume":"334","author":"Takeda","year":"2011","journal-title":"Science"},{"key":"2024061223452308200_DEV139691C121","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.cell.2014.12.032","article-title":"Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche","volume":"160","author":"Tamplin","year":"2015","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C122","doi-asserted-by":"publisher","first-page":"9399","DOI":"10.1073\/pnas.0700984104","article-title":"Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta","volume":"104","author":"Taoudi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061223452308200_DEV139691C123","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nature10408","article-title":"A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable","volume":"478","author":"Tian","year":"2011","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C124","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1182\/blood-2006-06-031898","article-title":"The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis","volume":"109","author":"Tober","year":"2007","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C125","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1182\/blood-2003-11-4011","article-title":"Hematopoiesis is severely altered in mice with an induced osteoblast deficiency","volume":"103","author":"Visnjic","year":"2004","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C126","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.cell.2007.05.014","article-title":"A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency","volume":"129","author":"Walkley","year":"2007","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C127","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.cell.2007.03.055","article-title":"Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment","volume":"129","author":"Walkley","year":"2007","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C128","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","article-title":"Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair","volume":"135","author":"Wilson","year":"2008","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C129","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.1182\/blood.V87.10.4082.bloodjournal87104082","article-title":"Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells","volume":"87","author":"Wineman","year":"1996","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C130","doi-asserted-by":"publisher","first-page":"4815","DOI":"10.1182\/blood-2009-11-253534","article-title":"Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs","volume":"116","author":"Winkler","year":"2010","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C131","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/S0301-472X(02)00881-0","article-title":"Roles of spleen and liver in development of the murine hematopoietic system","volume":"30","author":"Wolber","year":"2002","journal-title":"Exp. Hematol."},{"key":"2024061223452308200_DEV139691C132","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1182\/blood.V92.6.2032","article-title":"Stimulation of mouse and human primitive hematopoiesis by murine embryonic aorta-gonad-mesonephros-derived stromal cell lines","volume":"92","author":"Xu","year":"1998","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C133","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.cell.2011.09.053","article-title":"Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche","volume":"147","author":"Yamazaki","year":"2011","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C134","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.cell.2016.10.045","article-title":"Epigenetic memory underlies cell-autonomous heterogeneous behavior of hematopoietic stem cells","volume":"167","author":"Yu","year":"2016","journal-title":"Cell"},{"key":"2024061223452308200_DEV139691C135","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1182\/blood-2003-08-2955","article-title":"Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells","volume":"103","author":"Zhang","year":"2004","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C136","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/nature02041","article-title":"Identification of the haematopoietic stem cell niche and control of the niche size","volume":"425","author":"Zhang","year":"2003","journal-title":"Nature"},{"key":"2024061223452308200_DEV139691C137","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/nm.3706","article-title":"Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells","volume":"20","author":"Zhao","year":"2014","journal-title":"Nat. Med."},{"key":"2024061223452308200_DEV139691C138","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1182\/blood-2015-03-633354","article-title":"ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver","volume":"126","author":"Zhao","year":"2015","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C139","doi-asserted-by":"publisher","first-page":"e05521","DOI":"10.7554\/eLife.05521","article-title":"Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1","volume":"4","author":"Zhou","year":"2015","journal-title":"Elife"},{"key":"2024061223452308200_DEV139691C140","doi-asserted-by":"publisher","first-page":"3706","DOI":"10.1182\/blood-2006-08-041384","article-title":"Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells","volume":"109","author":"Zhu","year":"2007","journal-title":"Blood"},{"key":"2024061223452308200_DEV139691C141","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.stem.2009.09.003","article-title":"Time to cut the cord: placental HSCs grow up","volume":"5","author":"Zovein","year":"2009","journal-title":"Cell Stem Cell"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.139691","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.139691\/3476652\/dev139691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.139691\/3476652\/dev139691.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T23:45:36Z","timestamp":1718235936000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/145\/2\/dev139691\/48796\/The-hematopoietic-stem-cell-niche-from-embryo-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":141,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.139691","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,15]]},"article-number":"dev139691"}}