{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:00:48Z","timestamp":1790668848975,"version":"4.1.0"},"reference-count":50,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T00:00:00Z","timestamp":1508025600000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100016964","name":"Werner Siemens-Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016964","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["156838"],"award-info":[{"award-number":["156838"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:p>The cardiovascular system forms during early embryogenesis and adapts to embryonic growth by sprouting angiogenesis and vascular remodeling. These processes require fine-tuning of cell-cell adhesion to maintain and re-establish endothelial contacts, while allowing cell motility. We have compared the contribution of two endothelial cell-specific adhesion proteins, VE-cadherin (VE-cad\/Cdh5) and Esama (endothelial cell-selective adhesion molecule a), during angiogenic sprouting and blood vessel fusion (anastomosis) in the zebrafish embryo by genetic analyses. Different combinations of mutant alleles can be placed into a phenotypic series with increasing defects in filopodial contact formation. Contact formation in esama mutants appears similar to wild type, whereas esama\u2212\/\u2212; ve-cad+\/\u2212 and ve-cad single mutants exhibit intermediate phenotypes. The lack of both proteins interrupts filopodial interaction completely. Furthermore, double mutants do not form a stable endothelial monolayer, and display intrajunctional gaps, dislocalization of Zo-1 and defects in apical-basal polarization. In summary, VE-cadherin and Esama have distinct and redundant functions during blood vessel morphogenesis, and both adhesion proteins are central to endothelial cell recognition during anastomosis.<\/jats:p>","DOI":"10.1242\/dev.140038","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T01:10:25Z","timestamp":1488849025000},"page":"1554-1565","source":"Crossref","is-referenced-by-count":49,"title":["Distinct and redundant functions of Esama and VE-cadherin during vascular morphogenesis"],"prefix":"10.1242","volume":"144","author":[{"given":"Lo\u00efc","family":"Sauteur","sequence":"first","affiliation":[{"name":"Biozentrum der Universit\u00e4t Basel , Klingelbergstrasse 70, Basel CH-4056 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Affolter","sequence":"additional","affiliation":[{"name":"Biozentrum der Universit\u00e4t Basel , Klingelbergstrasse 70, Basel CH-4056 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-4364","authenticated-orcid":false,"given":"Heinz-Georg","family":"Belting","sequence":"additional","affiliation":[{"name":"Biozentrum der Universit\u00e4t Basel , Klingelbergstrasse 70, Basel CH-4056 , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2024061216055806300_DEV140038C1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.gde.2004.12.005","article-title":"Cellular abnormalities of blood vessels as targets in cancer","volume":"15","author":"Baluk","year":"2005","journal-title":"Curr. 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