{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:09:11Z","timestamp":1761523751799,"version":"3.41.2"},"reference-count":73,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"the Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Swedish Cancer Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Grainy head (Grh) is a conserved transcription factor (TF) controlling epithelial differentiation and regeneration. To elucidate Grh functions, we identified embryonic Grh targets by ChIP-seq and gene expression analysis. We show that Grh controls hundreds of target genes. Repression or activation correlates with the distance of Grh binding sites to the transcription start sites of its targets. Analysis of 54 Grh-responsive enhancers during development and upon wounding suggests cooperation with distinct TFs in different contexts. In the airways, Grh repressed genes encode key TFs involved in branching and cell differentiation. Reduction of the POU-domain TF, Vvl, (ventral veins lacking) largely ameliorates the airway morphogenesis defects of grh mutants. Vvl and Grh proteins additionally interact with each other and regulate a set of common enhancers during epithelial morphogenesis. We conclude that Grh and Vvl participate in a regulatory network controlling epithelial maturation.<\/jats:p>","DOI":"10.1242\/dev.143297","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:30:21Z","timestamp":1501547421000},"source":"Crossref","is-referenced-by-count":15,"title":["Genome-wide identification of Grainy head targets in <i>Drosophila<\/i> reveals regulatory interactions with the POU-domain transcription factor, Vvl"],"prefix":"10.1242","author":[{"given":"Liqun","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, S10691, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, S10691, Stockholm, Sweden"},{"name":"Cancer Biology & Genetics Program, Sloan-Kettering Institute, 1275 York Ave, Box 252, New York, NY 10065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Orzechowski-Westholm","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Ave, Box 252, New York, NY 10065, United States"},{"name":"Science for Life Laboratory, Tomtebodav\u00e4gen 232, 171 21 Solna, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Ave, Box 252, New York, NY 10065, United States"},{"name":"Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, S10691, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, S10691, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Hosono","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, S10691, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bray","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Sloan-Kettering Institute, 1275 York Ave, Box 252, New York, NY 10065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-6040","authenticated-orcid":false,"given":"Christos","family":"Samakovlis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, S10691, Stockholm, Sweden"},{"name":"Science for Life Laboratory, Tomtebodav\u00e4gen 232, 171 21 Solna, Sweden"},{"name":"Molecular Pneumology, UGMLC, Aulweg 130, 35392, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2021042608522961800_DEV143297C1","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.mod.2005.08.004","article-title":"Regulation of post-embryonic neuroblasts by Drosophila Grainyhead","volume":"122","author":"Almeida","year":"2005","journal-title":"Mech. 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