{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:04:12Z","timestamp":1772168652610,"version":"3.50.1"},"reference-count":55,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22122003"],"award-info":[{"award-number":["22122003"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H02618"],"award-info":[{"award-number":["16H02618"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AMED-CREST","award":["13414779"],"award-info":[{"award-number":["13414779"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The heart is an endocrine organ, because cardiomyocytes (CMs) secrete natriuretic peptide (NP) hormones. Since the discovery of NPs, no peptide hormones that affect remote organs have been identified from the heart. We identified osteocrine (Ostn) as an osteogenesis\/chondrogenesis regulatory hormone secreted from CMs in zebrafish. The ostn mutant larvae exhibited impaired membranous and chondral bone formation. The impaired bones were recovered by CM-specific overexpression of Ostn. We analyzed parasphenoid (ps) as a representative of membranous bones. In the shortened ps of the ostn morphants, nuclear Yap1\/Wwtr1-dependent transcription was increased, suggesting that Ostn might induce the nuclear export of Yap1\/Wwtr1 in osteoblasts. Although OSTN is proposed to bind to NPR3 (clearance receptor for NPs) to enhance the binding of NPs to NPR1 or NPR2, OSTN enhanced C-type NP-dependent nuclear export of YAP1\/WWTR1 of cultured osteoblasts stimulated with saturable CNP. OSTN, therefore, might activate unidentified receptors that augment protein kinase G signaling mediated by a CNP-NPR2 signaling axis. These data demonstrate that Ostn secreted from the heart contributes to bone formation as an endocrine hormone.<\/jats:p>","DOI":"10.1242\/dev.143354","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T21:20:31Z","timestamp":1482182431000},"source":"Crossref","is-referenced-by-count":16,"title":["Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish"],"prefix":"10.1242","author":[{"given":"Ayano","family":"Chiba","sequence":"first","affiliation":[{"name":"Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruko","family":"Watanabe-Takano","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Terai","sequence":"additional","affiliation":[{"name":"Laboratory of Function and Morphology, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Uemura","sequence":"additional","affiliation":[{"name":"Laboratory of Function and Morphology, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Organogenesis and Organ Function, Bioscience and Biotechnology Center, Graduate School of Science Nagoya, Nagoya University, Furo-cho, Chigusa-ku, Nagoya, Aichi 464-8061, Japan"},{"name":"Devision of Biological Science, Graduate School of Science Nagoya, Nagoya University, Furo-cho, Chigusa-ku, Nagoya, Aichi 464-8061, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Hibi","sequence":"additional","affiliation":[{"name":"Laboratory of Organogenesis and Organ Function, Bioscience and Biotechnology Center, Graduate School of Science Nagoya, Nagoya University, Furo-cho, Chigusa-ku, Nagoya, Aichi 464-8061, Japan"},{"name":"Devision of Biological Science, Graduate School of Science Nagoya, Nagoya University, Furo-cho, Chigusa-ku, Nagoya, Aichi 464-8061, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetomo","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathophysiology, Institute of Advanced Medical Science, Nippon Medical School, 1-396 Kosugi-machi, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-9602","authenticated-orcid":false,"given":"Naoki","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan"},{"name":"AMED-CREST, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2021042608590931000_DEV143354C1","doi-asserted-by":"publisher","first-page":"4552","DOI":"10.1038\/ncomms5552","article-title":"Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart","volume":"5","author":"Arita","year":"2014","journal-title":"Nat. Commun."},{"key":"2021042608590931000_DEV143354C2","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1073\/pnas.0704963105","article-title":"Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish","volume":"105","author":"Asakawa","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608590931000_DEV143354C3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1242\/dev.100370","article-title":"Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development","volume":"141","author":"Becker","year":"2014","journal-title":"Development"},{"key":"2021042608590931000_DEV143354C4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.bone.2013.09.024","article-title":"FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression","volume":"58","author":"Byun","year":"2014","journal-title":"Bone"},{"key":"2021042608590931000_DEV143354C5","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1534\/g3.113.007310","article-title":"Characterization of two ENU-induced mutations affecting mouse skeletal morphology","volume":"3","author":"Dauphinee","year":"2013","journal-title":"G3 (Bethesda)"},{"key":"2021042608590931000_DEV143354C6","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1016\/j.celrep.2016.02.021","article-title":"Yap1 regulates multiple steps of chondrocyte differentiation during skeletal development and bone repair","volume":"14","author":"Deng","year":"2016","journal-title":"Cell Rep."},{"key":"2021042608590931000_DEV143354C7","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.bbrc.2007.11.140","article-title":"FGF-2 signaling induces downregulation of TAZ protein in osteoblastic MC3T3-E1 cells","volume":"366","author":"Eda","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042608590931000_DEV143354C8","doi-asserted-by":"crossref","first-page":"10729","DOI":"10.1016\/S0021-9258(17)34119-4","article-title":"Autocrine regulation of rat chondrocyte proliferation by natriuretic peptide C and its receptor, natriuretic peptide receptor-B","volume":"269","author":"Hagiwara","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2021042608590931000_DEV143354C9","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1126\/science.1110955","article-title":"TAZ, a transcriptional modulator of mesenchymal stem cell differentiation","volume":"309","author":"Hong","year":"2005","journal-title":"Science"},{"key":"2021042608590931000_DEV143354C10","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/ncb3164","article-title":"Inactivation of a Galpha(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis","volume":"17","author":"Iglesias-Bartolome","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"2021042608590931000_DEV143354C11","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1242\/dev.00505","article-title":"Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development","volume":"130","author":"Ivkovic","year":"2003","journal-title":"Development"},{"key":"2021042608590931000_DEV143354C12","doi-asserted-by":"publisher","first-page":"10278","DOI":"10.1073\/pnas.96.18.10278","article-title":"Three new allelic mouse mutations that cause skeletal overgrowth involve the natriuretic peptide receptor C gene (Npr3)","volume":"96","author":"Jaubert","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608590931000_DEV143354C13","doi-asserted-by":"publisher","first-page":"E1339","DOI":"10.1152\/ajpendo.00272.2009","article-title":"Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice","volume":"297","author":"Kake","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021042608590931000_DEV143354C14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1146\/annurev.cellbio.042308.113308","article-title":"Genetic control of bone formation","volume":"25","author":"Karsenty","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2021042608590931000_DEV143354C15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1242\/dev.115576","article-title":"beta-Catenin-dependent transcription is central to Bmp-mediated formation of venous vessels","volume":"142","author":"Kashiwada","year":"2015","journal-title":"Development"},{"key":"2021042608590931000_DEV143354C16","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1038\/emboj.2013.102","article-title":"cAMP\/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes","volume":"32","author":"Kim","year":"2013","journal-title":"EMBO J."},{"key":"2021042608590931000_DEV143354C17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"2021042608590931000_DEV143354C18","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.devcel.2011.04.014","article-title":"Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin","volume":"20","author":"Knopf","year":"2011","journal-title":"Dev. Cell"},{"key":"2021042608590931000_DEV143354C19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s007740200048","article-title":"Significance of C-type natriuretic peptide (CNP) in endochondral ossification: analysis of CNP knockout mice","volume":"20","author":"Komatsu","year":"2002","journal-title":"J. Bone Miner. Metab."},{"key":"2021042608590931000_DEV143354C20","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"2021042608590931000_DEV143354C21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/dvdy.21838","article-title":"Tracking gene expression during zebrafish osteoblast differentiation","volume":"238","author":"Li","year":"2009","journal-title":"Dev. Dyn."},{"key":"2021042608590931000_DEV143354C22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1210\/en.2013-1608","article-title":"Calcium-sensing receptor mediates Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin","volume":"155","author":"Lin","year":"2014","journal-title":"Endocrinology"},{"key":"2021042608590931000_DEV143354C23","doi-asserted-by":"publisher","first-page":"a008334","DOI":"10.1101\/cshperspect.a008334","article-title":"Development of the endochondral skeleton","volume":"5","author":"Long","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2021042608590931000_DEV143354C24","doi-asserted-by":"publisher","first-page":"7403","DOI":"10.1073\/pnas.96.13.7403","article-title":"The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system","volume":"96","author":"Matsukawa","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608590931000_DEV143354C25","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s00018-009-8716-3","article-title":"Osteocrin--beyond just another bone protein?","volume":"66","author":"Moffatt","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"2021042608590931000_DEV143354C26","doi-asserted-by":"publisher","first-page":"36454","DOI":"10.1074\/jbc.M708596200","article-title":"Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth","volume":"282","author":"Moffatt","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021042608590931000_DEV143354C27","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/jcp.24491","article-title":"Connective tissue growth factor (CTGF\/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling","volume":"229","author":"Mundy","year":"2014","journal-title":"J. Cell Physiol."},{"key":"2021042608590931000_DEV143354C28","doi-asserted-by":"publisher","first-page":"19391","DOI":"10.1074\/jbc.C400066200","article-title":"Musclin, a novel skeletal muscle-derived secretory factor","volume":"279","author":"Nishizawa","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021042608590931000_DEV143354C29","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1530\/EC-14-0012","article-title":"The heart as an endocrine organ","volume":"3","author":"Ogawa","year":"2014","journal-title":"Endocr. Connect."},{"key":"2021042608590931000_DEV143354C30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1210\/er.2005-0014","article-title":"Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions","volume":"27","author":"Potter","year":"2006","journal-title":"Endocr. Rev."},{"key":"2021042608590931000_DEV143354C31","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1093\/cvr\/cvr035","article-title":"Vascularizing the heart","volume":"91","author":"Riley","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"2021042608590931000_DEV143354C32","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1242\/dev.124.15.2945","article-title":"Musculoskeletal patterning in the pharyngeal segments of the zebrafish embryo","volume":"124","author":"Schilling","year":"1997","journal-title":"Development"},{"key":"2021042608590931000_DEV143354C33","doi-asserted-by":"publisher","first-page":"4374","DOI":"10.1210\/en.2008-0254","article-title":"Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia","volume":"149","author":"Smerdel-Ramoya","year":"2008","journal-title":"Endocrinology"},{"key":"2021042608590931000_DEV143354C34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i1.10","article-title":"Signaling networks that control the lineage commitment and differentiation of bone cells","volume":"19","author":"Soltanoff","year":"2009","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"2021042608590931000_DEV143354C35","doi-asserted-by":"publisher","first-page":"3765","DOI":"10.1242\/dev.024034","article-title":"Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton","volume":"135","author":"Spoorendonk","year":"2008","journal-title":"Development"},{"key":"2021042608590931000_DEV143354C36","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/S0196-9781(99)00129-1","article-title":"mRNA quantification of C-type natriuretic peptide in brain areas of rodents","volume":"20","author":"Stepan","year":"1999","journal-title":"Peptides"},{"key":"2021042608590931000_DEV143354C37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000048004","article-title":"Expression of C-type natriuretic peptide in human placenta and myometrium in normal pregnancies and pregnancies complicated by intrauterine growth retardation. Preliminary results","volume":"17","author":"Stepan","year":"2002","journal-title":"Fetal Diagn. Ther."},{"key":"2021042608590931000_DEV143354C38","doi-asserted-by":"publisher","first-page":"16042","DOI":"10.1073\/pnas.1514250112","article-title":"Musclin is an activity-stimulated myokine that enhances physical endurance","volume":"112","author":"Subbotina","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608590931000_DEV143354C39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/bbrc.1996.0836","article-title":"C-type natriuretic peptide as an autocrine\/paracrine regulator of osteoblast. Evidence for possible presence of bone natriuretic peptide system","volume":"223","author":"Suda","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042608590931000_DEV143354C40","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1073\/pnas.95.5.2337","article-title":"Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide","volume":"95","author":"Suda","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608590931000_DEV143354C41","doi-asserted-by":"publisher","first-page":"17300","DOI":"10.1073\/pnas.0407894101","article-title":"Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs","volume":"101","author":"Tamura","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608590931000_DEV143354C42","doi-asserted-by":"publisher","first-page":"50563","DOI":"10.1074\/jbc.M307310200","article-title":"Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype","volume":"278","author":"Thomas","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021042608590931000_DEV143354C43","doi-asserted-by":"publisher","first-page":"R549","DOI":"10.1152\/ajpregu.90742.2008","article-title":"Effects of stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo","volume":"296","author":"Tseng","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"2021042608590931000_DEV143354C44","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1242\/dev.102376","article-title":"The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease","volume":"141","author":"Varelas","year":"2014","journal-title":"Development"},{"key":"2021042608590931000_DEV143354C45","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1002\/dvdy.20734","article-title":"Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): differential involvement in the visceral skeleton and braincase","volume":"235","author":"Verreijdt","year":"2006","journal-title":"Dev. Dyn."},{"key":"2021042608590931000_DEV143354C46","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.1073\/pnas.1116136109","article-title":"YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy","volume":"109","author":"von","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2021042608590931000_DEV143354C55","author":"Westerfield","year":"2007","journal-title":"The Zebrafish Book. A Guide for the Laboratory Used of Zebrafsih (Danio rerio)"},{"key":"2021042608590931000_DEV143354C47","doi-asserted-by":"publisher","first-page":"e56585","DOI":"10.1371\/journal.pone.0056585","article-title":"Osteoblast-targeted overexpression of TAZ increases bone mass in vivo","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS ONE"},{"key":"2021042608590931000_DEV143354C48","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/nm971","article-title":"Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway","volume":"10","author":"Yasoda","year":"2004","journal-title":"Nat. Med."},{"key":"2021042608590931000_DEV143354C49","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/sj.emboj.7600073","article-title":"Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription","volume":"23","author":"Zaidi","year":"2004","journal-title":"EMBO J."},{"key":"2021042608590931000_DEV143354C50","doi-asserted-by":"publisher","first-page":"13355","DOI":"10.1074\/jbc.M900843200","article-title":"TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021042608590931000_DEV143354C51","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"key":"2021042608590931000_DEV143354C52","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev."},{"key":"2021042608590931000_DEV143354C53","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"key":"2021042608590931000_DEV143354C54","doi-asserted-by":"publisher","first-page":"12919","DOI":"10.1073\/pnas.0912855107","article-title":"Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice","volume":"107","author":"Zhou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.143354","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/144\/2\/334\/1849227\/dev143354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.143354\/2053224\/dev_143354v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.143354\/2053224\/dev_143354v1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T13:00:03Z","timestamp":1621342803000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/doi\/10.1242\/dev.143354\/264277\/Osteocrin-a-peptide-secreted-from-the-heart-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1242\/dev.143354","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727127700.793526820","asserted-by":"object"}]},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]},"article-number":"dev.143354"}}