{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:11:41Z","timestamp":1791598301956,"version":"4.3.4"},"reference-count":61,"publisher":"The Company of Biologists","issue":"17","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.biologists.com\/user-licence-1-1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:p>Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout life, and understanding how these cells function has important implications for understanding male infertility. Recently, various populations of cells harbouring stem cell-like properties have been identified in rodent seminiferous tubules, but deciphering how these cells might fuel spermatogenesis has been difficult, and various models to explain SSC dynamics have been put forward. This Review provides an overview of the organization and timing of spermatogenesis and then discusses these models in light of recent studies of SSC markers, heterogeneity and cell division dynamics, highlighting the evidence for and against each model.<\/jats:p>","DOI":"10.1242\/dev.146571","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T07:25:10Z","timestamp":1503991510000},"page":"3022-3030","source":"Crossref","is-referenced-by-count":302,"title":["The nature and dynamics of spermatogonial stem cells"],"prefix":"10.1242","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3932-4419","authenticated-orcid":false,"given":"Dirk G.","family":"de Rooij","sequence":"first","affiliation":[{"name":"Reproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht 3584 CH, The Netherlands"},{"name":"Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042608531513100_DEV146571C1","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/j.dnarep.2007.02.011","article-title":"Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1","volume":"6","author":"Ahmed","year":"2007","journal-title":"DNA Repair"},{"key":"2021042608531513100_DEV146571C2","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1172\/JCI75943","article-title":"PAX7 expression defines germline stem cells in the adult testis","volume":"124","author":"Aloisio","year":"2014","journal-title":"J. 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