{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T18:49:10Z","timestamp":1776970150855,"version":"3.51.4"},"reference-count":70,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["S-24228005"],"award-info":[{"award-number":["S-24228005"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["C-24500485"],"award-info":[{"award-number":["C-24500485"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD066121"],"award-info":[{"award-number":["R01 HD066121"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,15]]},"abstract":"<jats:p>The gallbladder excretes cytotoxic bile acids into the duodenum through the cystic duct and common bile duct system. Sox17 haploinsufficiency causes biliary atresia-like phenotypes and hepatitis in late organogenesis mouse embryos, but the molecular and cellular mechanisms underlying this remain unclear. In this study, transcriptomic analyses revealed the early onset of cholecystitis in Sox17+\/\u2212 embryos, together with the appearance of ectopic cystic duct-like epithelia in their gallbladders. The embryonic hepatitis showed positive correlations with the severity of cholecystitis in individual Sox17+\/\u2212 embryos. Embryonic hepatitis could be induced by conditional deletion of Sox17 in the primordial gallbladder epithelia but not in fetal liver hepatoblasts. The Sox17+\/\u2212 gallbladder also showed a drastic reduction in sonic hedgehog expression, leading to aberrant smooth muscle formation and defective contraction of the fetal gallbladder. The defective gallbladder contraction positively correlated with the severity of embryonic hepatitis in Sox17+\/\u2212 embryos, suggesting a potential contribution of embryonic cholecystitis and fetal gallbladder contraction in the early pathogenesis of congenital biliary atresia.<\/jats:p>","DOI":"10.1242\/dev.147512","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T00:10:35Z","timestamp":1492819835000},"page":"1906-1917","source":"Crossref","is-referenced-by-count":29,"title":["Embryonic cholecystitis and defective gallbladder contraction in the <i>Sox17<\/i>-haploinsufficient mouse model of biliary atresia"],"prefix":"10.1242","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-8139","authenticated-orcid":false,"given":"Hiroki","family":"Higashiyama","sequence":"first","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0506-5909","authenticated-orcid":false,"given":"Aisa","family":"Ozawa","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-7846","authenticated-orcid":false,"given":"Hiroyuki","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0036-3103","authenticated-orcid":false,"given":"Mami","family":"Uemura","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"},{"name":"Center for Experimental Animals, Tokyo Medical and Dental University 2 , Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8510 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Fujino","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Igarashi","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Imaimatsu","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Tsunekawa","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Hirate","sequence":"additional","affiliation":[{"name":"Center for Experimental Animals, Tokyo Medical and Dental University 2 , Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8510 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Kurohmaru","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Saijoh","sequence":"additional","affiliation":[{"name":"The University of Utah, Salt Lake City 3 Department of Neurobiology and Anatomy , , UT 84132-3401 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Kanai-Azuma","sequence":"additional","affiliation":[{"name":"Center for Experimental Animals, Tokyo Medical and Dental University 2 , Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8510 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-7806","authenticated-orcid":false,"given":"Yoshiakira","family":"Kanai","sequence":"additional","affiliation":[{"name":"The University of Tokyo 1 Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2024061213252699000_DEV147512C1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S0960-9822(06)00340-X","article-title":"Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas","volume":"7","author":"Apelqvist","year":"1997","journal-title":"Curr. Biol."},{"key":"2024061213252699000_DEV147512C2","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrgastro.2015.74","article-title":"Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes","volume":"12","author":"Asai","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2024061213252699000_DEV147512C3","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/hep.24537","article-title":"Dual farnesoid X receptor\/TGR5 agonist INT-767 reduces liver injury in the Mdr2\u2212\/\u2212 (Abcb4\u2212\/\u2212) mouse cholangiopathy model by promoting biliary HCO3\u2212 output","volume":"54","author":"Baghdasaryan","year":"2011","journal-title":"Hepatology"},{"key":"2024061213252699000_DEV147512C4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/hep.27045","article-title":"Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease","volume":"60","author":"Bessho","year":"2014","journal-title":"Hepatology"},{"key":"2024061213252699000_DEV147512C5","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1242\/dev.022442","article-title":"Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4","volume":"135","author":"Caubit","year":"2008","journal-title":"Development"},{"key":"2024061213252699000_DEV147512C6","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1053\/j.gastro.2013.01.022","article-title":"Evidence from human and zebrafish that GPC1 is a biliary atresia susceptibility gene","volume":"144","author":"Cui","year":"2013","journal-title":"Gastroenterology"},{"key":"2024061213252699000_DEV147512C7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jpedsurg.2015.10.058","article-title":"Biliary atresia: from Australia to the zebrafish","volume":"51","author":"Davenport","year":"2016","journal-title":"J. Pediatr. Surg."},{"key":"2024061213252699000_DEV147512C8","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1002\/hep.1840160434","article-title":"Congenital diseases of intrahepatic bile ducts: variations on the theme \u201cductal plate malformation\u201d","volume":"16","author":"Desmet","year":"1992","journal-title":"Hepatology"},{"key":"2024061213252699000_DEV147512C9","doi-asserted-by":"publisher","first-page":"e53675","DOI":"10.1371\/journal.pone.0053675","article-title":"Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development","volume":"8","author":"DeSouza","year":"2013","journal-title":"PLoS ONE"},{"key":"2024061213252699000_DEV147512C10","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity","volume":"75","author":"Echelard","year":"1993","journal-title":"Cell"},{"issue":"Suppl.","key":"2024061213252699000_DEV147512C11","doi-asserted-by":"publisher","first-page":"W755","DOI":"10.1093\/nar\/gkq405","article-title":"AltAnalyze and DomainGraph: analyzing and visualizing exon expression data","volume":"38","author":"Emig","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2024061213252699000_DEV147512C12","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1080\/00365520701320521","article-title":"Multiple inflammatory-, tissue remodelling-and fibrosis genes are differentially transcribed in the livers of Abcb4 (-\/-) mice harbouring chronic cholangitis","volume":"42","author":"Esten Nakken","year":"2007","journal-title":"Scandinav. J. Gastroenterol."},{"key":"2024061213252699000_DEV147512C13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1053\/j.gastro.2004.04.009","article-title":"Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice","volume":"127","author":"Fickert","year":"2004","journal-title":"Gastroenterology"},{"key":"2024061213252699000_DEV147512C14","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/ng.722","article-title":"Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine","volume":"43","author":"Furuyama","year":"2011","journal-title":"Nat. Genet."},{"key":"2024061213252699000_DEV147512C15","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.crohns.2011.09.013","article-title":"Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD","volume":"6","author":"Gersemann","year":"2012","journal-title":"J. Crohns Colitis"},{"key":"2024061213252699000_DEV147512C16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1136\/gutjnl-2014-306896","article-title":"Functional analysis of ABCB4 mutations relates clinical outcomes of progressive familial intrahepatic cholestasis type 3 to the degree of MDR3 floppase activity","volume":"64","author":"Gordo-Gilart","year":"2015","journal-title":"Gut"},{"key":"2024061213252699000_DEV147512C17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"key":"2024061213252699000_DEV147512C18","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/MPG.0b013e318200eb6f","article-title":"Investigation of primary cilia in the pathogenesis of biliary atresia","volume":"52","author":"Hartley","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"2024061213252699000_DEV147512C19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/ar.23287","article-title":"Anatomy of the murine hepatobiliary system: a whole-organ-level analysis using a transparency method","volume":"299","author":"Higashiyama","year":"2016","journal-title":"Anat. Rec."},{"key":"2024061213252699000_DEV147512C20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1535-6108(03)00309-X","article-title":"Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse","volume":"4","author":"Hingorani","year":"2003","journal-title":"Cancer Cell"},{"key":"2024061213252699000_DEV147512C21","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1242\/dev.029587","article-title":"A critical time window of Sry action in gonadal sex determination in mice","volume":"136","author":"Hiramatsu","year":"2009","journal-title":"Development"},{"key":"2024061213252699000_DEV147512C22","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1124\/mol.114.095141","article-title":"An overview of hedgehog signaling in fibrosis","volume":"87","author":"Hu","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"2024061213252699000_DEV147512C23","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"2024061213252699000_DEV147512C24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2024061213252699000_DEV147512C25","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jpedsurg.2014.08.025","article-title":"Sonic hedgehog (SHH) and glioblastoma-2 (Gli-2) expressions are associated with poor jaundice-free survival in biliary atresia","volume":"50","author":"Jung","year":"2015","journal-title":"J. Pediatr. Surg."},{"key":"2024061213252699000_DEV147512C26","doi-asserted-by":"publisher","first-page":"12369","DOI":"10.1074\/jbc.M112162200","article-title":"Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development","volume":"277","author":"Kalinichenko","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2024061213252699000_DEV147512C27","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1242\/dev.091793","article-title":"Sox proteins: regulators of cell fate specification and differentiation","volume":"140","author":"Kamachi","year":"2013","journal-title":"Development"},{"key":"2024061213252699000_DEV147512C28","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1083\/jcb.133.3.667","article-title":"Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis","volume":"133","author":"Kanai","year":"1996","journal-title":"J. Cell Biol."},{"key":"2024061213252699000_DEV147512C29","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1242\/dev.129.10.2367","article-title":"Depletion of definitive gut endoderm in Sox17-null mutant mice","volume":"129","author":"Kanai-Azuma","year":"2002","journal-title":"Development"},{"key":"2024061213252699000_DEV147512C30","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.2214\/ajr.181.5.1811387","article-title":"Sonographic diagnosis of biliary atresia in pediatric patients using the \u201ctriangular cord\u201d sign versus gallbladder length and contraction","volume":"181","author":"Kanegawa","year":"2003","journal-title":"Am. J. Roentgenology"},{"key":"2024061213252699000_DEV147512C31","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1002\/j.1460-2075.1996.tb00900.x","article-title":"Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha","volume":"15","author":"Kelliher","year":"1996","journal-title":"EMBO J."},{"key":"2024061213252699000_DEV147512C32","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.ydbio.2004.11.006","article-title":"Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice","volume":"278","author":"Kidokoro","year":"2005","journal-title":"Dev. Biol."},{"key":"2024061213252699000_DEV147512C33","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2007.06.011","article-title":"Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells","volume":"130","author":"Kim","year":"2007","journal-title":"Cell"},{"key":"2024061213252699000_DEV147512C34","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1053\/jhep.2002.35820","article-title":"The significance of human jagged 1 mutations detected in severe cases of extrahepatic biliary atresia","volume":"36","author":"Kohsaka","year":"2002","journal-title":"Hepatology"},{"key":"2024061213252699000_DEV147512C35","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s00383-005-1589-0","article-title":"Gene expression profile of the infective murine model for biliary atresia","volume":"22","author":"Leonhardt","year":"2006","journal-title":"Pediatr. Surg. Int."},{"key":"2024061213252699000_DEV147512C36","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ydbio.2004.03.009","article-title":"Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis","volume":"270","author":"Li","year":"2004","journal-title":"Dev. Biol."},{"key":"2024061213252699000_DEV147512C37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1119(97)00668-9","article-title":"Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway","volume":"209","author":"Liu","year":"1998","journal-title":"Gene"},{"key":"2024061213252699000_DEV147512C38","doi-asserted-by":"publisher","first-page":"11056","DOI":"10.1073\/pnas.1001269107","article-title":"Olfactomedin 4 down-regulates innate immunity against Helicobacter pylori infection","volume":"107","author":"Liu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024061213252699000_DEV147512C70","doi-asserted-by":"crossref","first-page":"286ra67","DOI":"10.1126\/scitranslmed.aaa1652","article-title":"Identification of a plant isoflavonoid that causes biliary atresia","volume":"7","author":"Lorent","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"2024061213252699000_DEV147512C39","doi-asserted-by":"publisher","first-page":"87R","DOI":"10.1203\/01.PDR.0000159569.57354.47","article-title":"Unraveling the pathogenesis and etiology of biliary atresia","volume":"57","author":"Mack","year":"2005","journal-title":"Pediatr. Res."},{"key":"2024061213252699000_DEV147512C40","doi-asserted-by":"publisher","first-page":"5936","DOI":"10.1074\/jbc.M808103200","article-title":"FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine","volume":"284","author":"Madison","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2024061213252699000_DEV147512C41","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1242\/dev.044586","article-title":"Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract","volume":"137","author":"Mao","year":"2010","journal-title":"Development"},{"key":"2024061213252699000_DEV147512C42","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1152\/physrev.00058.2009","article-title":"Mammalian Kr\u00fcppel-like factors in health and diseases","volume":"90","author":"McConnell","year":"2010","journal-title":"Physiol. Rev."},{"key":"2024061213252699000_DEV147512C43","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1093\/nar\/27.5.1359","article-title":"The DNA-binding specificity of SOX9 and other SOX proteins","volume":"27","author":"Mertin","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"2024061213252699000_DEV147512C44","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s00281-009-0171-6","article-title":"Biliary atresia","volume":"31","author":"Mieli-Vergani","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"2024061213252699000_DEV147512C45","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0925-4773(98)00149-X","article-title":"Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis","volume":"78","author":"Motoyama","year":"1998","journal-title":"Mech. Dev."},{"key":"2024061213252699000_DEV147512C46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0022-2275(20)42749-X","article-title":"Bile acid metabolism in early life: studies of amniotic fluid","volume":"31","author":"Nakagawa","year":"1990","journal-title":"J. Lipid Res."},{"key":"2024061213252699000_DEV147512C47","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00534-013-0604-4","article-title":"Etiology of biliary atresia as a developmental anomaly: recent advances","volume":"20","author":"Nakamura","year":"2013","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"2024061213252699000_DEV147512C48","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1872-034X.2010.00631.x","article-title":"Analysis of HLA-DRB1 polymorphisms in Japanese patients with primary biliary cirrhosis (PBC): the HLA-DRB1 polymorphism determines the relative risk of antinuclear antibodies for disease progression in PBC","volume":"40","author":"Nakamura","year":"2010","journal-title":"Hepatol. Res."},{"key":"2024061213252699000_DEV147512C49","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1089\/scd.2011.0229","article-title":"Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development","volume":"21","author":"Okada","year":"2012","journal-title":"Stem Cells Dev."},{"key":"2024061213252699000_DEV147512C50","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/MOG.0b013e32834550b4","article-title":"Hedgehog signaling in cholangiocytes","volume":"27","author":"Omenetti","year":"2011","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2024061213252699000_DEV147512C51","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1136\/gut.2008.148619","article-title":"The hedgehog pathway regulates remodelling responses to biliary obstruction in rats","volume":"57","author":"Omenetti","year":"2008","journal-title":"Gut"},{"key":"2024061213252699000_DEV147512C52","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s00424-006-0062-9","article-title":"Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein)","volume":"453","author":"Oude Elferink","year":"2007","journal-title":"Pflugers Arch."},{"key":"2024061213252699000_DEV147512C53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2016.03.018","article-title":"Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases","volume":"163","author":"Park","year":"2016","journal-title":"Pharmacol. Therap."},{"key":"2024061213252699000_DEV147512C54","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.ydbio.2015.05.012","article-title":"Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts","volume":"404","author":"Poncy","year":"2015","journal-title":"Dev. Biol."},{"key":"2024061213252699000_DEV147512C55","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11894-004-0043-0","article-title":"Smooth muscle function and dysfunction in gallbladder disease","volume":"6","author":"Portincasa","year":"2004","journal-title":"Curr. Gastroenterol. Rep."},{"key":"2024061213252699000_DEV147512C56","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1002\/hep.22204","article-title":"Coordinate regulation of gallbladder motor function in the gut-liver axis","volume":"47","author":"Portincasa","year":"2008","journal-title":"Hepatology"},{"key":"2024061213252699000_DEV147512C57","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1074\/jbc.274.1.305","article-title":"Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase","volume":"274","author":"Postic","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2024061213252699000_DEV147512C58","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1002\/hep.22771","article-title":"High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis","volume":"49","author":"Schaap","year":"2009","journal-title":"Hepatology"},{"key":"2024061213252699000_DEV147512C59","doi-asserted-by":"publisher","first-page":"7802","DOI":"10.1128\/MCB.02179-06","article-title":"Sox17 and Sox4 differentially regulate \u03b2-catenin\/T-cell factor activity and proliferation of colon carcinoma cells","volume":"27","author":"Sinner","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"2024061213252699000_DEV147512C60","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.devcel.2009.05.012","article-title":"Sox17 regulates organ lineage segregation of ventral foregut progenitor cells","volume":"17","author":"Spence","year":"2009","journal-title":"Dev. Cell"},{"key":"2024061213252699000_DEV147512C61","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"2024061213252699000_DEV147512C62","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S0959-437X(03)00085-6","article-title":"Early endoderm development in vertebrates: lineage differentiation and morphogenetic function","volume":"13","author":"Tam","year":"2003","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2024061213252699000_DEV147512C63","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/0022-3468(94)90144-9","article-title":"Does the morphology of the extrahepatic biliary remnants in biliary atresia influence survival? A review of 205 cases","volume":"29","author":"Tan","year":"1994","journal-title":"J. Pediatr. Surg."},{"key":"2024061213252699000_DEV147512C64","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/MPG.0000000000001375","article-title":"Loss of a candidate biliary atresia susceptibility gene, add3a, causes biliary developmental defects in zebrafish","volume":"63","author":"Tang","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"2024061213252699000_DEV147512C65","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.bbrc.2009.11.063","article-title":"Expression and function of mouse Sox17 gene in the specification of gallbladder\/bile-duct progenitors during early foregut morphogenesis","volume":"391","author":"Uemura","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2024061213252699000_DEV147512C66","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1242\/dev.086702","article-title":"Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL\/6 background mice","volume":"140","author":"Uemura","year":"2013","journal-title":"Development"},{"key":"2024061213252699000_DEV147512C67","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1152\/physrev.00054.2006","article-title":"Hedgehog signaling in development and homeostasis of the gastrointestinal tract","volume":"87","author":"van den Brink","year":"2007","journal-title":"Physiol. Rev."},{"key":"2024061213252699000_DEV147512C68","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/hep.28599","article-title":"The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17","volume":"64","author":"Waisbourd-Zinman","year":"2016","journal-title":"Hepatology"},{"key":"2024061213252699000_DEV147512C69","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0959-437X(02)00323-4","article-title":"Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators","volume":"12","author":"Wilson","year":"2002","journal-title":"Curr. Opin. Genet. Dev."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1242\/dev.147512","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/144\/10\/1906\/3472832\/dev147512.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.147512\/2053417\/dev_147512v1.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/144\/10\/1906\/3472832\/dev147512.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:36:36Z","timestamp":1718199396000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/144\/10\/1906\/47913\/Embryonic-cholecystitis-and-defective-gallbladder"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,15]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,5,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.147512","relation":{},"ISSN":["1477-9129","0950-1991"],"issn-type":[{"value":"1477-9129","type":"electronic"},{"value":"0950-1991","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5,15]]}}}